Chronic Multisymptom Illness Complex in Gulf War I Veterans 10 Years Later
Prior research has demonstrated that shortly after the 1991 Gulf War (Gulf War I), chronic multisymptom illness (CMI) was more common among deployed veterans than among nondeployed veterans. The aims of the current study were to determine the prevalence of CMI among deployed and nondeployed veterans...
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| Veröffentlicht in: | American journal of epidemiology 2006-01, Vol.163 (1), p.66-75 |
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| container_title | American journal of epidemiology |
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| creator | Blanchard, Melvin S. Eisen, Seth A. Alpern, Renee Karlinsky, Joel Toomey, Rosemary Reda, Domenic J. Murphy, Frances M. Jackson, Leila W. Kang, Han K. |
| description | Prior research has demonstrated that shortly after the 1991 Gulf War (Gulf War I), chronic multisymptom illness (CMI) was more common among deployed veterans than among nondeployed veterans. The aims of the current study were to determine the prevalence of CMI among deployed and nondeployed veterans 10 years after Gulf War I, compare the distribution of comorbid conditions, and identify prewar factors associated with CMI. Cross-sectional data collected from 1,061 deployed veterans and 1,128 nondeployed veterans examined between 1999 and 2001 were analyzed. CMI prevalence was 28.9% among deployed veterans and 15.8% among nondeployed veterans (odds ratio = 2.16, 95% confidence interval: 1.61, 2.90). Deployed and nondeployed veterans with CMI had similarly poorer quality-of-life measures and higher prevalences of symptom-based medical conditions, metabolic syndrome, and psychiatric disorders. Diagnoses of prewar anxiety disorders (not related to post-traumatic stress disorder) and depression were associated with CMI among both deployed and nondeployed veterans. Nicotine dependence and veteran-reported physician-diagnosed infectious mononucleosis were associated with CMI among deployed veterans, and migraine headaches and gastritis were associated with CMI among nondeployed veterans. CMI continues to be substantially more prevalent among deployed veterans than among nondeployed veterans 10 years after Gulf War I, but it manifests similarly in both groups. It is likely to be a common, persistent problem among veterans returning from the current Gulf War. |
| doi_str_mv | 10.1093/aje/kwj008 |
| format | Article |
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The aims of the current study were to determine the prevalence of CMI among deployed and nondeployed veterans 10 years after Gulf War I, compare the distribution of comorbid conditions, and identify prewar factors associated with CMI. Cross-sectional data collected from 1,061 deployed veterans and 1,128 nondeployed veterans examined between 1999 and 2001 were analyzed. CMI prevalence was 28.9% among deployed veterans and 15.8% among nondeployed veterans (odds ratio = 2.16, 95% confidence interval: 1.61, 2.90). Deployed and nondeployed veterans with CMI had similarly poorer quality-of-life measures and higher prevalences of symptom-based medical conditions, metabolic syndrome, and psychiatric disorders. Diagnoses of prewar anxiety disorders (not related to post-traumatic stress disorder) and depression were associated with CMI among both deployed and nondeployed veterans. Nicotine dependence and veteran-reported physician-diagnosed infectious mononucleosis were associated with CMI among deployed veterans, and migraine headaches and gastritis were associated with CMI among nondeployed veterans. CMI continues to be substantially more prevalent among deployed veterans than among nondeployed veterans 10 years after Gulf War I, but it manifests similarly in both groups. It is likely to be a common, persistent problem among veterans returning from the current Gulf War.</description><identifier>ISSN: 0002-9262</identifier><identifier>EISSN: 1476-6256</identifier><identifier>DOI: 10.1093/aje/kwj008</identifier><identifier>PMID: 16293719</identifier><identifier>CODEN: AJEPAS</identifier><language>eng</language><publisher>Cary, NC: Oxford University Press</publisher><subject>Adult ; Analysis. Health state ; Biological and medical sciences ; Chronic Disease ; Chronic illnesses ; chronic multisymptom illness ; CMI ; Comorbidity ; Cross-Sectional Studies ; Epidemiology ; Female ; General aspects ; Gulf War ; Humans ; Male ; Medical Outcomes Study Short Form 36 ; Medical sciences ; Metabolic diseases ; metabolic syndrome X ; Middle Aged ; Military Medicine ; Military Personnel - statistics & numerical data ; Miscellaneous ; Other metabolic disorders ; Persian Gulf syndrome ; Persian Gulf Syndrome - epidemiology ; Persian Gulf Syndrome - physiopathology ; Persian Gulf War ; post-traumatic stress disorder ; Prevalence ; psychological ; PTSD ; Public health. Hygiene ; Public health. Hygiene-occupational medicine ; Quality of Life ; Risk Assessment ; Risk Factors ; SF-36 ; Sickness Impact Profile ; Stress ; Time Factors ; United States - epidemiology ; Veterans ; Veterans - statistics & numerical data</subject><ispartof>American journal of epidemiology, 2006-01, Vol.163 (1), p.66-75</ispartof><rights>2006 INIST-CNRS</rights><rights>Copyright Oxford University Press(England) Jan 1, 2006</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c478t-60b6da1cd0cda4b0caf1cc2b09fe282fb4f825f33e075015d0691acf8d6455fc3</citedby><cites>FETCH-LOGICAL-c478t-60b6da1cd0cda4b0caf1cc2b09fe282fb4f825f33e075015d0691acf8d6455fc3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,4024,27923,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=17606812$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/16293719$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Blanchard, Melvin S.</creatorcontrib><creatorcontrib>Eisen, Seth A.</creatorcontrib><creatorcontrib>Alpern, Renee</creatorcontrib><creatorcontrib>Karlinsky, Joel</creatorcontrib><creatorcontrib>Toomey, Rosemary</creatorcontrib><creatorcontrib>Reda, Domenic J.</creatorcontrib><creatorcontrib>Murphy, Frances M.</creatorcontrib><creatorcontrib>Jackson, Leila W.</creatorcontrib><creatorcontrib>Kang, Han K.</creatorcontrib><title>Chronic Multisymptom Illness Complex in Gulf War I Veterans 10 Years Later</title><title>American journal of epidemiology</title><addtitle>Am. J. Epidemiol</addtitle><description>Prior research has demonstrated that shortly after the 1991 Gulf War (Gulf War I), chronic multisymptom illness (CMI) was more common among deployed veterans than among nondeployed veterans. The aims of the current study were to determine the prevalence of CMI among deployed and nondeployed veterans 10 years after Gulf War I, compare the distribution of comorbid conditions, and identify prewar factors associated with CMI. Cross-sectional data collected from 1,061 deployed veterans and 1,128 nondeployed veterans examined between 1999 and 2001 were analyzed. CMI prevalence was 28.9% among deployed veterans and 15.8% among nondeployed veterans (odds ratio = 2.16, 95% confidence interval: 1.61, 2.90). Deployed and nondeployed veterans with CMI had similarly poorer quality-of-life measures and higher prevalences of symptom-based medical conditions, metabolic syndrome, and psychiatric disorders. Diagnoses of prewar anxiety disorders (not related to post-traumatic stress disorder) and depression were associated with CMI among both deployed and nondeployed veterans. Nicotine dependence and veteran-reported physician-diagnosed infectious mononucleosis were associated with CMI among deployed veterans, and migraine headaches and gastritis were associated with CMI among nondeployed veterans. CMI continues to be substantially more prevalent among deployed veterans than among nondeployed veterans 10 years after Gulf War I, but it manifests similarly in both groups. It is likely to be a common, persistent problem among veterans returning from the current Gulf War.</description><subject>Adult</subject><subject>Analysis. Health state</subject><subject>Biological and medical sciences</subject><subject>Chronic Disease</subject><subject>Chronic illnesses</subject><subject>chronic multisymptom illness</subject><subject>CMI</subject><subject>Comorbidity</subject><subject>Cross-Sectional Studies</subject><subject>Epidemiology</subject><subject>Female</subject><subject>General aspects</subject><subject>Gulf War</subject><subject>Humans</subject><subject>Male</subject><subject>Medical Outcomes Study Short Form 36</subject><subject>Medical sciences</subject><subject>Metabolic diseases</subject><subject>metabolic syndrome X</subject><subject>Middle Aged</subject><subject>Military Medicine</subject><subject>Military Personnel - statistics & numerical data</subject><subject>Miscellaneous</subject><subject>Other metabolic disorders</subject><subject>Persian Gulf syndrome</subject><subject>Persian Gulf Syndrome - epidemiology</subject><subject>Persian Gulf Syndrome - physiopathology</subject><subject>Persian Gulf War</subject><subject>post-traumatic stress disorder</subject><subject>Prevalence</subject><subject>psychological</subject><subject>PTSD</subject><subject>Public health. Hygiene</subject><subject>Public health. Hygiene-occupational medicine</subject><subject>Quality of Life</subject><subject>Risk Assessment</subject><subject>Risk Factors</subject><subject>SF-36</subject><subject>Sickness Impact Profile</subject><subject>Stress</subject><subject>Time Factors</subject><subject>United States - epidemiology</subject><subject>Veterans</subject><subject>Veterans - statistics & numerical data</subject><issn>0002-9262</issn><issn>1476-6256</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2006</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpd0F1rFDEUgOEgil2rN_4ACYK9EMaek0ySyaUMtl1dUbBq7U3IZBKc7XysyQy2_97ILha8Cpw8HA4vIc8R3iBofmq3_vTm9xagekBWWCpZSCbkQ7ICAFZoJtkReZJSBohawGNyhJJprlCvyPv6Z5zGztGPSz936W7YzdNA130_-pRoPQ273t_SbqTnSx_odxvpmn7zs492TBSB_vA2JrqxefKUPAq2T_7Z4T0mX8_eXdYXxebT-bp-uylcqaq5kNDI1qJrwbW2bMDZgM6xBnTwrGKhKUPFRODcgxKAogWp0bpQtbIUIjh-TE72e3dx-rX4NJuhS873vR39tCSDqkTNUWb48j-4nZY45tsM46JCzrTK6PUeuTilFH0wu9gNNt4ZBPM3r8l5zT5vxi8OG5dm8O09PfTM4NUB2ORsH3Im16V7pyTICll2xd51afa3__5tvDFScSXMxdW1ua7Vpfp89cV84H8A5OyRkw</recordid><startdate>20060101</startdate><enddate>20060101</enddate><creator>Blanchard, Melvin S.</creator><creator>Eisen, Seth A.</creator><creator>Alpern, Renee</creator><creator>Karlinsky, Joel</creator><creator>Toomey, Rosemary</creator><creator>Reda, Domenic J.</creator><creator>Murphy, Frances M.</creator><creator>Jackson, Leila W.</creator><creator>Kang, Han K.</creator><general>Oxford University Press</general><general>Oxford Publishing Limited (England)</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QP</scope><scope>7T2</scope><scope>7TK</scope><scope>7U7</scope><scope>7U9</scope><scope>C1K</scope><scope>H94</scope><scope>K9.</scope><scope>NAPCQ</scope></search><sort><creationdate>20060101</creationdate><title>Chronic Multisymptom Illness Complex in Gulf War I Veterans 10 Years Later</title><author>Blanchard, Melvin S. ; Eisen, Seth A. ; Alpern, Renee ; Karlinsky, Joel ; Toomey, Rosemary ; Reda, Domenic J. ; Murphy, Frances M. ; Jackson, Leila W. ; Kang, Han K.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c478t-60b6da1cd0cda4b0caf1cc2b09fe282fb4f825f33e075015d0691acf8d6455fc3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2006</creationdate><topic>Adult</topic><topic>Analysis. Health state</topic><topic>Biological and medical sciences</topic><topic>Chronic Disease</topic><topic>Chronic illnesses</topic><topic>chronic multisymptom illness</topic><topic>CMI</topic><topic>Comorbidity</topic><topic>Cross-Sectional Studies</topic><topic>Epidemiology</topic><topic>Female</topic><topic>General aspects</topic><topic>Gulf War</topic><topic>Humans</topic><topic>Male</topic><topic>Medical Outcomes Study Short Form 36</topic><topic>Medical sciences</topic><topic>Metabolic diseases</topic><topic>metabolic syndrome X</topic><topic>Middle Aged</topic><topic>Military Medicine</topic><topic>Military Personnel - statistics & numerical data</topic><topic>Miscellaneous</topic><topic>Other metabolic disorders</topic><topic>Persian Gulf syndrome</topic><topic>Persian Gulf Syndrome - epidemiology</topic><topic>Persian Gulf Syndrome - physiopathology</topic><topic>Persian Gulf War</topic><topic>post-traumatic stress disorder</topic><topic>Prevalence</topic><topic>psychological</topic><topic>PTSD</topic><topic>Public health. 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J. Epidemiol</addtitle><date>2006-01-01</date><risdate>2006</risdate><volume>163</volume><issue>1</issue><spage>66</spage><epage>75</epage><pages>66-75</pages><issn>0002-9262</issn><eissn>1476-6256</eissn><coden>AJEPAS</coden><abstract>Prior research has demonstrated that shortly after the 1991 Gulf War (Gulf War I), chronic multisymptom illness (CMI) was more common among deployed veterans than among nondeployed veterans. The aims of the current study were to determine the prevalence of CMI among deployed and nondeployed veterans 10 years after Gulf War I, compare the distribution of comorbid conditions, and identify prewar factors associated with CMI. Cross-sectional data collected from 1,061 deployed veterans and 1,128 nondeployed veterans examined between 1999 and 2001 were analyzed. CMI prevalence was 28.9% among deployed veterans and 15.8% among nondeployed veterans (odds ratio = 2.16, 95% confidence interval: 1.61, 2.90). Deployed and nondeployed veterans with CMI had similarly poorer quality-of-life measures and higher prevalences of symptom-based medical conditions, metabolic syndrome, and psychiatric disorders. Diagnoses of prewar anxiety disorders (not related to post-traumatic stress disorder) and depression were associated with CMI among both deployed and nondeployed veterans. Nicotine dependence and veteran-reported physician-diagnosed infectious mononucleosis were associated with CMI among deployed veterans, and migraine headaches and gastritis were associated with CMI among nondeployed veterans. CMI continues to be substantially more prevalent among deployed veterans than among nondeployed veterans 10 years after Gulf War I, but it manifests similarly in both groups. It is likely to be a common, persistent problem among veterans returning from the current Gulf War.</abstract><cop>Cary, NC</cop><pub>Oxford University Press</pub><pmid>16293719</pmid><doi>10.1093/aje/kwj008</doi><tpages>10</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Adult Analysis. Health state Biological and medical sciences Chronic Disease Chronic illnesses chronic multisymptom illness CMI Comorbidity Cross-Sectional Studies Epidemiology Female General aspects Gulf War Humans Male Medical Outcomes Study Short Form 36 Medical sciences Metabolic diseases metabolic syndrome X Middle Aged Military Medicine Military Personnel - statistics & numerical data Miscellaneous Other metabolic disorders Persian Gulf syndrome Persian Gulf Syndrome - epidemiology Persian Gulf Syndrome - physiopathology Persian Gulf War post-traumatic stress disorder Prevalence psychological PTSD Public health. Hygiene Public health. Hygiene-occupational medicine Quality of Life Risk Assessment Risk Factors SF-36 Sickness Impact Profile Stress Time Factors United States - epidemiology Veterans Veterans - statistics & numerical data |
| title | Chronic Multisymptom Illness Complex in Gulf War I Veterans 10 Years Later |
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