BRCA1 promoter methylation in sporadic breast cancer is associated with reduced BRCA1 copy number and chromosome 17 aneusomy

To explore the molecular mechanisms for the similarities between inherited and noninherited forms of breast cancer, we tested the hypothesis that inactivation of BRCA1 by promoter hypermethylation is associated with reduced gene copy number and chromosome 17 aneusomy as observed in tumors from BRCA1...

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Veröffentlicht in:	Cancer research (Chicago, Ill.) Ill.), 2005-12, Vol.65 (23), p.10692-10699
Hauptverfasser:	MINJIE WEI, GRUSHKO, Tatyana A, OLOPADE, Olufunmilayo I, DIGNAM, James, HAGOS, Fitsum, NANDA, Rita, SVEEN, Lise, JINHUA XU, FACKENTHAL, James, TRETIAKOVA, Maria, DAS, Soma
Format:	Artikel
Sprache:	eng
Schlagworte:	Aneuploidy Antimetabolites, Antineoplastic - pharmacology Azacitidine - analogs & derivatives Azacitidine - pharmacology Biological and medical sciences BRCA1 Protein - biosynthesis BRCA1 Protein - deficiency BRCA1 Protein - genetics Breast - metabolism Breast - physiology Breast - ultrastructure Breast Neoplasms - genetics Breast Neoplasms - metabolism Cell Line, Tumor Chromosomes, Human, Pair 17 - genetics DNA Methylation - drug effects Female Gene Dosage Gene Expression - drug effects Genes, BRCA1 - physiology Gynecology. Andrology. Obstetrics Humans Hydroxamic Acids - pharmacology Lymphocytes - metabolism Lymphocytes - physiology Mammary gland diseases Medical sciences Middle Aged Promoter Regions, Genetic RNA, Messenger - biosynthesis RNA, Messenger - genetics Tumors
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