The pre-B-cell receptor induces silencing of VpreB and [lamda]5 transcription

The pre-B-cell receptor (pre-BCR), composed of Ig heavy and surrogate light chain (SLC), signals pre-BII-cell proliferative expansion. We have investigated whether the pre-BCR also signals downregulation of the SLC genes (VpreB and lambda5), thereby limiting this expansion. We demonstrate that, as B...

Ausführliche Beschreibung

Bibliographische Detailangaben

Veröffentlicht in:	The EMBO journal 2005-11, Vol.24 (22), p.3895-3905
Hauptverfasser:	Parker, Mathew J, Licence, Steve, Erlandsson, Lena, Galler, Gunther R, Chakalova, Lyubomira, Osborne, Cameron S, Morgan, Geoff, Fraser, Peter, Jumaa, Hassan, Winkler, Thomas H, Skok, Jane, Mårtensson, Inga-Lill
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!