Predominance of three NF-κB binding sites in the long terminal repeat region of HIV type 1 subtype C isolates from Zambia
Human immunodeficiency virus type-1 (HIV-1) is a leading cause of mortality and morbidity in the world, with almost 46 million people infected globally. HIV-1 subtype C accounts for 55% of these infections. In Zambia, the majority of HIV-1 infections are subtype C. However, to its north most countri...
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| Veröffentlicht in: | AIDS research and human retroviruses 2005-10, Vol.21 (10), p.901-906 |
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| creator | MUNKANTA, Mwansa HANDEMA, Ray TERUNUMA, Hiroshi KASAI, Hirotake GONDWE, Clement XUEWEN DENG YAMASHITA, Atsuya ASAGI, Tsukasa YAMAMOTO, Naoki ITO, Masahiko KASOLO, Francis |
| description | Human immunodeficiency virus type-1 (HIV-1) is a leading cause of mortality and morbidity in the world, with almost 46 million people infected globally. HIV-1 subtype C accounts for 55% of these infections. In Zambia, the majority of HIV-1 infections are subtype C. However, to its north most countries have non-subtype C as the most predominant HIV-1 subtype while to its south most of them are predominantly subtype C. The aim of this study was to determine the subtype distribution and to analyze the long terminal repeat (LTR) region of HIV-1 isolates from the northern part of Zambia. We amplified as well as directly sequenced the LTR, gag, and env regions of 78 HIV-1 peripheral blood samples from adult Zambians. Our results show 95% (74/78) of our isolates were HIV-1 subtype C. Furthermore, of the subtype C samples analyzed across the LTR, 61% (25/41) carried 3 NF- Kappa B signature binding site sequences. |
| doi_str_mv | 10.1089/aid.2005.21.901 |
| format | Article |
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HIV-1 subtype C accounts for 55% of these infections. In Zambia, the majority of HIV-1 infections are subtype C. However, to its north most countries have non-subtype C as the most predominant HIV-1 subtype while to its south most of them are predominantly subtype C. The aim of this study was to determine the subtype distribution and to analyze the long terminal repeat (LTR) region of HIV-1 isolates from the northern part of Zambia. We amplified as well as directly sequenced the LTR, gag, and env regions of 78 HIV-1 peripheral blood samples from adult Zambians. Our results show 95% (74/78) of our isolates were HIV-1 subtype C. 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HIV-1 subtype C accounts for 55% of these infections. In Zambia, the majority of HIV-1 infections are subtype C. However, to its north most countries have non-subtype C as the most predominant HIV-1 subtype while to its south most of them are predominantly subtype C. The aim of this study was to determine the subtype distribution and to analyze the long terminal repeat (LTR) region of HIV-1 isolates from the northern part of Zambia. We amplified as well as directly sequenced the LTR, gag, and env regions of 78 HIV-1 peripheral blood samples from adult Zambians. Our results show 95% (74/78) of our isolates were HIV-1 subtype C. Furthermore, of the subtype C samples analyzed across the LTR, 61% (25/41) carried 3 NF- Kappa B signature binding site sequences.</description><subject>Biological and medical sciences</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Human immunodeficiency virus 1</subject><subject>Human viral diseases</subject><subject>Infectious diseases</subject><subject>Medical sciences</subject><subject>Microbiology</subject><subject>Miscellaneous</subject><subject>Viral diseases</subject><subject>Virology</subject><issn>0889-2229</issn><issn>1931-8405</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2005</creationdate><recordtype>article</recordtype><recordid>eNpFkL1OwzAUhS0EEqUws3qBLal_6tYeoeKnEgIGxMBi3Th2MUriYqdDeTQegmfCoZWYztW555zhQ-ickpISqSbg65IRIkpGS0XoARpRxWkhp0QcohGRUhWMMXWMTlL6IIQoxsQIfT1HW4fWd9AZi4PD_Xu0Fj_eFj_f17jyXe27FU6-twn7Ln8tbkJ2ehuHUoOjXVvos6x86IaB--Ur7rdriylOm-rvWmCfQgPDhouhxW_QVh5O0ZGDJtmzvY7Ry-3Ny-K-eHi6Wy6uHgrDCeuLqeNM1bwibEalIpWpgMu6BmkrI7PvAIgAIYyQs4oLURvCctpMnavnAHyMLnez6xg-Nzb1uvXJ2KaBzoZN0nQ-pTMu5jk42QVNDClF6_Q6-hbiVlOiB8Q6I9YDYs2ozohz42I_DclA42KG6NN_bc6oUlLxX6I0fkI</recordid><startdate>20051001</startdate><enddate>20051001</enddate><creator>MUNKANTA, Mwansa</creator><creator>HANDEMA, Ray</creator><creator>TERUNUMA, Hiroshi</creator><creator>KASAI, Hirotake</creator><creator>GONDWE, Clement</creator><creator>XUEWEN DENG</creator><creator>YAMASHITA, Atsuya</creator><creator>ASAGI, Tsukasa</creator><creator>YAMAMOTO, Naoki</creator><creator>ITO, Masahiko</creator><creator>KASOLO, Francis</creator><general>Liebert</general><scope>IQODW</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7U9</scope><scope>H94</scope></search><sort><creationdate>20051001</creationdate><title>Predominance of three NF-κB binding sites in the long terminal repeat region of HIV type 1 subtype C isolates from Zambia</title><author>MUNKANTA, Mwansa ; HANDEMA, Ray ; TERUNUMA, Hiroshi ; KASAI, Hirotake ; GONDWE, Clement ; XUEWEN DENG ; YAMASHITA, Atsuya ; ASAGI, Tsukasa ; YAMAMOTO, Naoki ; ITO, Masahiko ; KASOLO, Francis</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c302t-4f329d3b0261890bcba38dda8ebc8d3bfaa05a55c586b355dc023b0c4ffd7aa3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2005</creationdate><topic>Biological and medical sciences</topic><topic>Fundamental and applied biological sciences. 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| ispartof | AIDS research and human retroviruses, 2005-10, Vol.21 (10), p.901-906 |
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| language | eng |
| recordid | cdi_proquest_miscellaneous_17416357 |
| source | Mary Ann Liebert Online Subscription; Alma/SFX Local Collection |
| subjects | Biological and medical sciences Fundamental and applied biological sciences. Psychology Human immunodeficiency virus 1 Human viral diseases Infectious diseases Medical sciences Microbiology Miscellaneous Viral diseases Virology |
| title | Predominance of three NF-κB binding sites in the long terminal repeat region of HIV type 1 subtype C isolates from Zambia |
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