1,4- and 2,6-Disubstituted Amidoanthracene-9,10-dione Derivatives as Inhibitors of Human Telomerase

A number of 1,4- and 2,6-difunctionalized amidoanthracene-9,10-diones have been prepared. We have examined their in vitro cytotoxicity in several tumor cell lines and their ability to inhibit the telomere-addition function of the human telomerase enzyme together with their inhibition of the Taq poly...

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Veröffentlicht in:	Journal of medicinal chemistry 1998-08, Vol.41 (17), p.3253-3260
Hauptverfasser:	Perry, Philip J, Gowan, Sharon M, Reszka, Anthony P, Polucci, Paolo, Jenkins, Terence C, Kelland, Lloyd R, Neidle, Stephen
Format:	Artikel
Sprache:	eng
Schlagworte:	amidoanthracene-9,10-dione Anthraquinones - chemical synthesis Anthraquinones - chemistry Anthraquinones - pharmacology Anthraquinones - toxicity Antineoplastic agents Antineoplastic Agents - chemical synthesis Antineoplastic Agents - chemistry Antineoplastic Agents - toxicity Biological and medical sciences Cell Division - drug effects Cell Survival - drug effects Doxorubicin - toxicity Enzyme Inhibitors - chemical synthesis Enzyme Inhibitors - chemistry Enzyme Inhibitors - pharmacology Enzyme Inhibitors - toxicity Female Gene Amplification General aspects Humans Kinetics Medical sciences Mitoxantrone - toxicity Molecular Structure Ovarian Neoplasms Pharmacology. Drug treatments Structure-Activity Relationship Taq Polymerase - antagonists & inhibitors Telomerase - antagonists & inhibitors Telomere Tumor Cells, Cultured
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