Cocaine and Caffeine: Conditioned Place Preference, Locomotor Activity, and Additivity
Conditioned place preference (CPP) was employed to clarify the reinforcing and locomotor stimulating effects of several doses of cocaine and caffeine (0.32, 1.0, 3.2, 5.6, and 10.0 mg/kg) and to explore the possibility of additive effects between the two drugs. Additionally, the hypothesis that the...
Gespeichert in:
| Veröffentlicht in: | Pharmacology, biochemistry and behavior biochemistry and behavior, 1998-11, Vol.61 (3), p.291-296 |
|---|---|
| Hauptverfasser: | , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 296 |
|---|---|
| container_issue | 3 |
| container_start_page | 291 |
| container_title | Pharmacology, biochemistry and behavior |
| container_volume | 61 |
| creator | Bedingfield, J.Brent King, David A. Holloway, Frank A. |
| description | Conditioned place preference (CPP) was employed to clarify the reinforcing and locomotor stimulating effects of several doses of cocaine and caffeine (0.32, 1.0, 3.2, 5.6, and 10.0 mg/kg) and to explore the possibility of additive effects between the two drugs. Additionally, the hypothesis that the reinforcing effects of psychostimulants are mediated by the same systems that control psychostimulant-induced locomotor activity was examined by conducting correlational studies between drug-induced locomotor activity and time spent in the drug-conditioned compartments. Several doses of cocaine (1.0, 3.0, 5.6, 10.0 mg/kg), and caffeine (0.32, 1.0, 3.2, 5.6, 10.0) were found to condition place preference and stimulate locomotor activity. A combination of low doses (0.32 mg/kg) of each drug appeared to be additive. A positive relationship between locomotor activity observed during conditioning and time spent in the conditioned compartment during testing was found for cocaine but not caffeine or the low-dose combination of cocaine and caffeine. |
| doi_str_mv | 10.1016/S0091-3057(98)00092-6 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_17411456</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S0091305798000926</els_id><sourcerecordid>17411456</sourcerecordid><originalsourceid>FETCH-LOGICAL-c420t-ed9e8eefb3e63b28d967a5d4ef7ba0b2920d41c02387606d0dd1ad1880818a2a3</originalsourceid><addsrcrecordid>eNqFkF1LwzAUhoMoOqc_QeiFiMKqSdomqTcyil8wUPDjNqTJKUS6RpNu4L833cpuvQov53mTnAehM4KvCSbs5g3jkqQZLvhlKa5wTDRle2hCBM_SgnC-jyY75Agdh_AVoZwyfogOS85EwbIJ-qycVraDRHUmqVTTQAy3SeU6Y3vrOjDJa6s0JK8eGvDQaZglC6fd0vXOJ3Pd27Xtf2eb_twMpSGfoINGtQFOx3OKPh7u36undPHy-FzNF6nOKe5TMCUIgKbOgGU1FaZkXBUmh4bXCte0pNjkRGOaCc4wM9gYogwRAgsiFFXZFF1s7_327mcFoZdLGzS0rerArYIkPCckj5tOUbEFtXchxF3kt7dL5X8lwXLwKTc-5SBLlkJufMqhdzY-sKqXYHatUWCcn49zFbRqG686bcMOo3FNysqI3W0xiDLWFrwM2g4yjfWge2mc_ecjfwQ8kUM</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>17411456</pqid></control><display><type>article</type><title>Cocaine and Caffeine: Conditioned Place Preference, Locomotor Activity, and Additivity</title><source>MEDLINE</source><source>Elsevier ScienceDirect Journals</source><creator>Bedingfield, J.Brent ; King, David A. ; Holloway, Frank A.</creator><creatorcontrib>Bedingfield, J.Brent ; King, David A. ; Holloway, Frank A.</creatorcontrib><description>Conditioned place preference (CPP) was employed to clarify the reinforcing and locomotor stimulating effects of several doses of cocaine and caffeine (0.32, 1.0, 3.2, 5.6, and 10.0 mg/kg) and to explore the possibility of additive effects between the two drugs. Additionally, the hypothesis that the reinforcing effects of psychostimulants are mediated by the same systems that control psychostimulant-induced locomotor activity was examined by conducting correlational studies between drug-induced locomotor activity and time spent in the drug-conditioned compartments. Several doses of cocaine (1.0, 3.0, 5.6, 10.0 mg/kg), and caffeine (0.32, 1.0, 3.2, 5.6, 10.0) were found to condition place preference and stimulate locomotor activity. A combination of low doses (0.32 mg/kg) of each drug appeared to be additive. A positive relationship between locomotor activity observed during conditioning and time spent in the conditioned compartment during testing was found for cocaine but not caffeine or the low-dose combination of cocaine and caffeine.</description><identifier>ISSN: 0091-3057</identifier><identifier>EISSN: 1873-5177</identifier><identifier>DOI: 10.1016/S0091-3057(98)00092-6</identifier><identifier>PMID: 9768563</identifier><identifier>CODEN: PBBHAU</identifier><language>eng</language><publisher>New York, NY: Elsevier Inc</publisher><subject>Additivity ; Animals ; Biological and medical sciences ; Caffeine ; Caffeine - pharmacology ; Central Nervous System Stimulants - pharmacology ; Cocaine ; Cocaine - pharmacology ; Conditioned place preference ; Conditioning (Psychology) - drug effects ; Dopamine Uptake Inhibitors - pharmacology ; Drug Interactions ; Drug toxicity and drugs side effects treatment ; Locomotor activity ; Male ; Medical sciences ; Miscellaneous (drug allergy, mutagens, teratogens...) ; Motor Activity - drug effects ; Pharmacology. Drug treatments ; Rats ; Rats, Sprague-Dawley ; Reinforcement (Psychology)</subject><ispartof>Pharmacology, biochemistry and behavior, 1998-11, Vol.61 (3), p.291-296</ispartof><rights>1998 Elsevier Science Inc.</rights><rights>1998 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c420t-ed9e8eefb3e63b28d967a5d4ef7ba0b2920d41c02387606d0dd1ad1880818a2a3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0091305798000926$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=2420269$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/9768563$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Bedingfield, J.Brent</creatorcontrib><creatorcontrib>King, David A.</creatorcontrib><creatorcontrib>Holloway, Frank A.</creatorcontrib><title>Cocaine and Caffeine: Conditioned Place Preference, Locomotor Activity, and Additivity</title><title>Pharmacology, biochemistry and behavior</title><addtitle>Pharmacol Biochem Behav</addtitle><description>Conditioned place preference (CPP) was employed to clarify the reinforcing and locomotor stimulating effects of several doses of cocaine and caffeine (0.32, 1.0, 3.2, 5.6, and 10.0 mg/kg) and to explore the possibility of additive effects between the two drugs. Additionally, the hypothesis that the reinforcing effects of psychostimulants are mediated by the same systems that control psychostimulant-induced locomotor activity was examined by conducting correlational studies between drug-induced locomotor activity and time spent in the drug-conditioned compartments. Several doses of cocaine (1.0, 3.0, 5.6, 10.0 mg/kg), and caffeine (0.32, 1.0, 3.2, 5.6, 10.0) were found to condition place preference and stimulate locomotor activity. A combination of low doses (0.32 mg/kg) of each drug appeared to be additive. A positive relationship between locomotor activity observed during conditioning and time spent in the conditioned compartment during testing was found for cocaine but not caffeine or the low-dose combination of cocaine and caffeine.</description><subject>Additivity</subject><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Caffeine</subject><subject>Caffeine - pharmacology</subject><subject>Central Nervous System Stimulants - pharmacology</subject><subject>Cocaine</subject><subject>Cocaine - pharmacology</subject><subject>Conditioned place preference</subject><subject>Conditioning (Psychology) - drug effects</subject><subject>Dopamine Uptake Inhibitors - pharmacology</subject><subject>Drug Interactions</subject><subject>Drug toxicity and drugs side effects treatment</subject><subject>Locomotor activity</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Miscellaneous (drug allergy, mutagens, teratogens...)</subject><subject>Motor Activity - drug effects</subject><subject>Pharmacology. Drug treatments</subject><subject>Rats</subject><subject>Rats, Sprague-Dawley</subject><subject>Reinforcement (Psychology)</subject><issn>0091-3057</issn><issn>1873-5177</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1998</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkF1LwzAUhoMoOqc_QeiFiMKqSdomqTcyil8wUPDjNqTJKUS6RpNu4L833cpuvQov53mTnAehM4KvCSbs5g3jkqQZLvhlKa5wTDRle2hCBM_SgnC-jyY75Agdh_AVoZwyfogOS85EwbIJ-qycVraDRHUmqVTTQAy3SeU6Y3vrOjDJa6s0JK8eGvDQaZglC6fd0vXOJ3Pd27Xtf2eb_twMpSGfoINGtQFOx3OKPh7u36undPHy-FzNF6nOKe5TMCUIgKbOgGU1FaZkXBUmh4bXCte0pNjkRGOaCc4wM9gYogwRAgsiFFXZFF1s7_327mcFoZdLGzS0rerArYIkPCckj5tOUbEFtXchxF3kt7dL5X8lwXLwKTc-5SBLlkJufMqhdzY-sKqXYHatUWCcn49zFbRqG686bcMOo3FNysqI3W0xiDLWFrwM2g4yjfWge2mc_ecjfwQ8kUM</recordid><startdate>19981101</startdate><enddate>19981101</enddate><creator>Bedingfield, J.Brent</creator><creator>King, David A.</creator><creator>Holloway, Frank A.</creator><general>Elsevier Inc</general><general>Elsevier Science</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QG</scope><scope>7U7</scope><scope>C1K</scope></search><sort><creationdate>19981101</creationdate><title>Cocaine and Caffeine: Conditioned Place Preference, Locomotor Activity, and Additivity</title><author>Bedingfield, J.Brent ; King, David A. ; Holloway, Frank A.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c420t-ed9e8eefb3e63b28d967a5d4ef7ba0b2920d41c02387606d0dd1ad1880818a2a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1998</creationdate><topic>Additivity</topic><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Caffeine</topic><topic>Caffeine - pharmacology</topic><topic>Central Nervous System Stimulants - pharmacology</topic><topic>Cocaine</topic><topic>Cocaine - pharmacology</topic><topic>Conditioned place preference</topic><topic>Conditioning (Psychology) - drug effects</topic><topic>Dopamine Uptake Inhibitors - pharmacology</topic><topic>Drug Interactions</topic><topic>Drug toxicity and drugs side effects treatment</topic><topic>Locomotor activity</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Miscellaneous (drug allergy, mutagens, teratogens...)</topic><topic>Motor Activity - drug effects</topic><topic>Pharmacology. Drug treatments</topic><topic>Rats</topic><topic>Rats, Sprague-Dawley</topic><topic>Reinforcement (Psychology)</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Bedingfield, J.Brent</creatorcontrib><creatorcontrib>King, David A.</creatorcontrib><creatorcontrib>Holloway, Frank A.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Animal Behavior Abstracts</collection><collection>Toxicology Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><jtitle>Pharmacology, biochemistry and behavior</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Bedingfield, J.Brent</au><au>King, David A.</au><au>Holloway, Frank A.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Cocaine and Caffeine: Conditioned Place Preference, Locomotor Activity, and Additivity</atitle><jtitle>Pharmacology, biochemistry and behavior</jtitle><addtitle>Pharmacol Biochem Behav</addtitle><date>1998-11-01</date><risdate>1998</risdate><volume>61</volume><issue>3</issue><spage>291</spage><epage>296</epage><pages>291-296</pages><issn>0091-3057</issn><eissn>1873-5177</eissn><coden>PBBHAU</coden><abstract>Conditioned place preference (CPP) was employed to clarify the reinforcing and locomotor stimulating effects of several doses of cocaine and caffeine (0.32, 1.0, 3.2, 5.6, and 10.0 mg/kg) and to explore the possibility of additive effects between the two drugs. Additionally, the hypothesis that the reinforcing effects of psychostimulants are mediated by the same systems that control psychostimulant-induced locomotor activity was examined by conducting correlational studies between drug-induced locomotor activity and time spent in the drug-conditioned compartments. Several doses of cocaine (1.0, 3.0, 5.6, 10.0 mg/kg), and caffeine (0.32, 1.0, 3.2, 5.6, 10.0) were found to condition place preference and stimulate locomotor activity. A combination of low doses (0.32 mg/kg) of each drug appeared to be additive. A positive relationship between locomotor activity observed during conditioning and time spent in the conditioned compartment during testing was found for cocaine but not caffeine or the low-dose combination of cocaine and caffeine.</abstract><cop>New York, NY</cop><pub>Elsevier Inc</pub><pmid>9768563</pmid><doi>10.1016/S0091-3057(98)00092-6</doi><tpages>6</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0091-3057 |
| ispartof | Pharmacology, biochemistry and behavior, 1998-11, Vol.61 (3), p.291-296 |
| issn | 0091-3057 1873-5177 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_17411456 |
| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Additivity Animals Biological and medical sciences Caffeine Caffeine - pharmacology Central Nervous System Stimulants - pharmacology Cocaine Cocaine - pharmacology Conditioned place preference Conditioning (Psychology) - drug effects Dopamine Uptake Inhibitors - pharmacology Drug Interactions Drug toxicity and drugs side effects treatment Locomotor activity Male Medical sciences Miscellaneous (drug allergy, mutagens, teratogens...) Motor Activity - drug effects Pharmacology. Drug treatments Rats Rats, Sprague-Dawley Reinforcement (Psychology) |
| title | Cocaine and Caffeine: Conditioned Place Preference, Locomotor Activity, and Additivity |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-05T03%3A32%3A04IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Cocaine%20and%20Caffeine:%20Conditioned%20Place%20Preference,%20Locomotor%20Activity,%20and%20Additivity&rft.jtitle=Pharmacology,%20biochemistry%20and%20behavior&rft.au=Bedingfield,%20J.Brent&rft.date=1998-11-01&rft.volume=61&rft.issue=3&rft.spage=291&rft.epage=296&rft.pages=291-296&rft.issn=0091-3057&rft.eissn=1873-5177&rft.coden=PBBHAU&rft_id=info:doi/10.1016/S0091-3057(98)00092-6&rft_dat=%3Cproquest_cross%3E17411456%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=17411456&rft_id=info:pmid/9768563&rft_els_id=S0091305798000926&rfr_iscdi=true |