N-Nitrosodi- n-propylamine induces organ specific mutagenesis with specific expression times in lacZ transgenic mice

The mutagenic and clastogenic effects of N-nitrosodi- n-propylamine (NDPA) in lacZ transgenic mice (Muta™Mouse) were investigated as a part of the second collaborative study of the transgenic mouse mutation assay by a subgroup of the Mammalian Mutagenesis Study Group, a suborganization of the Enviro...

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Veröffentlicht in:	Mutation research 1999-08, Vol.444 (2), p.309-319
Hauptverfasser:	Itoh, Satoru, Miura, Miki, Itoh, Toshiaki, Miyauchi, Yoshiteru, Suga, Miho, Takahashi, Yukimi, Kasahara, Yoshinori, Yamamura, Eiji, Hirono, Haruyoshi, Shimada, Hiroyasu
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Carcinogens - toxicity Chemical mutagenesis Lac Operon lacZ lacZ gene Male Medical sciences Mice Mice, Transgenic Micronucleus Tests Mutagenesis Mutagenicity Mutagens - toxicity Muta™Mouse N-Nitrosodi- n-propylamine Nitrosamines - toxicity Organ Specificity Toxicology Transgenic mouse
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