Essential role of tumor necrosis factor α (TNF-α) in tumor promotion as revealed by TNF-α-deficient mice

To examine the hypothesis that tumor necrosis factor (TNF) alpha is an essential cytokine in carcinogenesis, we conducted two-stage carcinogenesis experiments with an initiator, 7,12-dimethylbenz(a)anthracene (DMBA), plus either of two tumor promoters, okadaic acid and 12-O-tetradecanoylphorbol-13-a...

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Veröffentlicht in:	Cancer research (Chicago, Ill.) Ill.), 1999-09, Vol.59 (18), p.4516-4518
Hauptverfasser:	SUGANUMA, M, OKABE, S, MARINO, M. W, SAKAI, A, SUEOKA, E, FUJIKI, H
Format:	Artikel
Sprache:	eng
Schlagworte:	3T3 Cells 9,10-Dimethyl-1,2-benzanthracene - toxicity Animal tumors. Experimental tumors Animals Biological and medical sciences Carcinogens - toxicity Cell Division - drug effects Cell Line, Transformed Experimental tumors, general aspects Female Genes, ras Interleukin-1 - genetics Interleukin-1 - pharmacology Interleukin-1 - physiology Male Medical sciences Mice Mice, Inbred Strains Mice, Knockout Okadaic Acid - toxicity Skin Neoplasms - chemically induced Skin Neoplasms - genetics Skin Neoplasms - pathology Tetradecanoylphorbol Acetate - toxicity Transfection Tumor Necrosis Factor-alpha - deficiency Tumor Necrosis Factor-alpha - genetics Tumor Necrosis Factor-alpha - physiology Tumors
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