Chronic administration of olmesartan attenuates the exaggerated pressor response to glutamate in the rostral ventrolateral medulla of SHR

It has been shown that the pressor responses to microinjection of l-glutamate in the rostral ventrolateral medulla (RVLM) are augmented in spontaneously hypertensive rats (SHR), and that these augmented responses are not altered by chronic conventional antihypertensive treatment. The aim of the pres...

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Veröffentlicht in:	Brain research 2005-10, Vol.1058 (1), p.161-166
Hauptverfasser:	Lin, Yingzi, Matsumura, Kiyoshi, Kagiyama, Shuntaro, Fukuhara, Masayo, Fujii, Koji, Iida, Mitsuo
Format:	Artikel
Sprache:	eng
Schlagworte:	Angiotensin II Angiotensin II Type 1 Receptor Blockers - pharmacology Animals Arterial hypertension. Arterial hypotension Autonomic Pathways - drug effects Autonomic Pathways - metabolism Autonomic Pathways - physiopathology Biological and medical sciences Blood and lymphatic vessels Blood Pressure - drug effects Blood Pressure - physiology Cardiology. Vascular system Drug Administration Schedule Drug Interactions - physiology Excitatory Amino Acid Agonists - pharmacology Experimental diseases Glutamate Glutamic Acid - metabolism Glutamic Acid - pharmacology Hypertension Hypertension - drug therapy Hypertension - metabolism Hypertension - physiopathology Imidazoles - pharmacology Imidazoles - therapeutic use Male Medical sciences Medulla Oblongata - drug effects Medulla Oblongata - metabolism Medulla Oblongata - physiopathology Rat Rats Rats, Inbred SHR Rats, Inbred WKY Receptors, N-Methyl-D-Aspartate - agonists Receptors, N-Methyl-D-Aspartate - metabolism Reticular Formation - drug effects Reticular Formation - metabolism Reticular Formation - physiopathology Rostral ventrolateral medulla Sympathetic Nervous System - drug effects Sympathetic Nervous System - metabolism Sympathetic Nervous System - physiopathology Synaptic Transmission - drug effects Synaptic Transmission - physiology Tetrazoles - pharmacology Tetrazoles - therapeutic use Treatment Outcome Vasoconstriction - drug effects Vasoconstriction - physiology
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