The initiation of colon cancer in a chronic inflammatory setting

Chronic inflammation predisposes to cancer. We used an inflammation-induced human model of tumorigenesis to explore how populations of mutated cells expand and initiate the earliest stages of cancer. Ulcerative colitis (UC) is a chronic inflammatory disease of the colon associated with an increased...

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Veröffentlicht in:	Carcinogenesis (New York) 2005-09, Vol.26 (9), p.1513-1519
Hauptverfasser:	Chen, Ru, Rabinovitch, Peter S., Crispin, David A., Emond, Mary J., Bronner, Mary P., Brentnall, Teresa A.
Format:	Artikel
Sprache:	eng
Schlagworte:	AP–PCR arbitrarily primed PCR Biological and medical sciences Biopsy Carcinogenesis, carcinogens and anticarcinogens Cell Transformation, Neoplastic Colitis, Ulcerative - complications Colitis, Ulcerative - pathology Colon - pathology Colonic Neoplasms - etiology Colonic Neoplasms - pathology DNA Fingerprinting FISH fluorescence in situ hybridization Humans In Situ Hybridization, Fluorescence Inflammation - complications Inflammation - pathology inter-simple-sequence-repeat PCR ISSR–PCR LOH (loss of heterozygosity) Medical sciences Mutation Polymerase Chain Reaction - methods simple-sequence-repeat SSR Tumors ulcerative colitis
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