Increased Expression of Rat Synuclein in the Substantia Nigra Pars Compacta Identified by mRNA Differential Display in a Model of Developmental Target Injury

: Human α‐synuclein was identified on the basis of proteolytic fragments derived from senile plaques of Alzheimer's disease, and it is the locus of mutations in some familial forms of Parkinson's disease. Its normal function and whether it may play a direct role in neural degeneration rema...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Journal of neurochemistry 1999-12, Vol.73 (6), p.2586-2599
Hauptverfasser:	Kholodilov, Nikolai G., Neystat, Michael, Tinmarla, F. Oo, Steven, E. Lo, Larsen, Kristin E., Sulzer, David, Burke, Robert E.
Format:	Artikel
Sprache:	eng
Schlagworte:	alpha-Synuclein Amino Acid Sequence Animals Apoptosis Apoptosis - drug effects Base Sequence Biological and medical sciences Blotting, Northern Blotting, Western Cells, Cultured Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases Dopamine - metabolism Dopaminergic neurons Gene Expression Profiling Gene Expression Regulation, Developmental Genes In Situ Hybridization Medical sciences Molecular Sequence Data Nerve Degeneration - chemically induced Nerve Degeneration - genetics Nerve Degeneration - metabolism Nerve Tissue Proteins - biosynthesis Nerve Tissue Proteins - genetics Neurology Neurons - drug effects Neurons - metabolism Neurotoxins - toxicity Parkinson Disease - metabolism Parkinson's disease Programmed cell death Quinolinic Acid - toxicity Rats Reverse Transcriptase Polymerase Chain Reaction RNA Splicing RNA, Antisense - pharmacology RNA, Messenger - biosynthesis Substantia nigra Substantia Nigra - drug effects Substantia Nigra - growth & development Substantia Nigra - metabolism Substantia Nigra - pathology Subtraction Technique Synuclein Synucleins
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!