The Effects of Methylmercury on Mitochondrial Function and Reactive Oxygen Species Formation in Rat Striatal Synaptosomes Are Age-Dependent

Methylmercury (MeHg) is especially toxic to the developing central nervous system. In order to understand the reasons for this age-dependent vulnerability, we compared the effects of MeHg on formation of reactive oxygen species (ROS) and mitochondrial function in striatal synaptosomes obtained from...

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Veröffentlicht in:	Toxicological sciences 2005-09, Vol.87 (1), p.156-162
Hauptverfasser:	Dreiem, Anne, Gertz, Caitlyn C., Seegal, Richard F.
Format:	Artikel
Sprache:	eng
Schlagworte:	Age Factors Animals Corpus Striatum - drug effects Corpus Striatum - metabolism development Male Membrane Potentials - drug effects methylmercury Methylmercury Compounds - toxicity mitochondria Mitochondria - drug effects Mitochondria - physiology Rats Rats, Long-Evans reactive oxygen species Reactive Oxygen Species - metabolism synaptosomes Synaptosomes - drug effects Synaptosomes - metabolism
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