A RA-dependent, tumour-growth suppressive transcription complex is the target of the PML-RARα and T18 oncoproteins

PML and Tif1a are fused to RARA and Braf , respectively, resulting in the production of PML-RARα and Tif1α-B-Raf (T18) oncoproteins. Here we show that PML, Tif1α and RXRα/RARα function together in a transcription complex that is dependent on retinoic acid (RA). We found that PML acts as a ligand-dep...

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Veröffentlicht in:	Nature genetics 1999-11, Vol.23 (3), p.287-295
Hauptverfasser:	Zhong, Sue, Delva, Laurent, Rachez, Christophe, Cenciarelli, Cristina, Gandini, Domenica, Zhang, Hui, Kalantry, Sundeep, Freedman, Leonard P., Pandolfi, Pier Paolo
Format:	Artikel
Sprache:	eng
Schlagworte:	Agriculture Animal Genetics and Genomics Biological and medical sciences Biomedical and Life Sciences Biomedicine Braf gene Cancer Research CBP protein Cell physiology Cell transformation and carcinogenesis. Action of oncogenes and antioncogenes Fundamental and applied biological sciences. Psychology Gene Function Human Genetics Molecular and cellular biology PML gene RARA gene RARB2 gene Tif1^a gene
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