Truncated BRCA2 Is Cytoplasmic: Implications for Cancer-Linked Mutations

BRCA2 mutations predispose carriers mainly to breast cancer. The vast majority of BRCA2 mutations are predicted to result in a truncated protein product. The smallest known cancer-associated deletion removes from the C terminus only 224 of the 3,418 residues constituting BRCA2, suggesting that these...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 1999-11, Vol.96 (24), p.13920-13925
Hauptverfasser:	Spain, Brian H., Larson, Christopher J., Shihabuddin, Lamya S., Gage, Fred H., Verma, Inder M.
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino acids Biological Sciences BRCA2 gene BRCA2 Protein Breast cancer Breast Neoplasms - genetics Cell Line, Transformed Cell lines Cell nucleus Cell Nucleus - metabolism Codons Cytoplasm - metabolism Female Fractionation Genetic mutation Genetics Humans Mutation Neoplasm Proteins - genetics Neoplasm Proteins - metabolism Nuclear Localization Signals Polymerase chain reaction Proteins Recombinant Fusion Proteins - genetics Recombinant Fusion Proteins - metabolism Sequence Deletion Transcription Factors - genetics Transcription Factors - metabolism Truncation Tumor Cells, Cultured
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