The Role of Thr139 in the Human Immunodeficiency Virus Type 1 Reverse Transcriptase Sensitivity to (+)-Calanolide A

The coumarins represent a unique class of non-nucleoside reverse transcriptase inhibitors (NNRTIs) that were isolated from tropical plants. (+)-Calanolide A, the most potent compound of this class, selects for the T139I resistance mutation in HIV-1 reverse transcriptase (RT). Seven RTs mutated at am...

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Veröffentlicht in:	Molecular pharmacology 2005-09, Vol.68 (3), p.652-659
Hauptverfasser:	Auwerx, Joeri, Rodríguez-Barrios, Fátima, Ceccherini-Silberstein, Francesca, San-Félix, Ana, Velázquez, Sonsoles, De Clercq, Erik, Camarasa, María-José, Perno, Carlo-Federico, Gago, Federico, Balzarini, Jan
Format:	Artikel
Sprache:	eng
Schlagworte:	Coumarins - pharmacology HIV Reverse Transcriptase - antagonists & inhibitors HIV Reverse Transcriptase - chemistry HIV Reverse Transcriptase - genetics Human immunodeficiency virus 1 Kinetics Models, Molecular Mutagenesis, Site-Directed Pyranocoumarins Reverse Transcriptase Inhibitors - pharmacology Threonine - chemistry Threonine - physiology
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