Tracking Antigen-Specific CD8 T Lymphocytes in the Lungs of Mice Vaccinated with the Mtb72F Polyprotein

This study used a major histocompatibility complex class I tetramer reagent to track antigen-specific CD8 T cells in the lungs of mice immunized with the tuberculosis vaccine candidate Mtb72F. The results show that CD8 T cells recognizing an immunodominant Mtb32-specific epitope could be detected in...

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Veröffentlicht in:	Infection and Immunity 2005-09, Vol.73 (9), p.5809-5816
Hauptverfasser:	Irwin, Scott M, Izzo, Angelo A, Dow, Steven W, Skeiky, Y. A. W, Reed, Steven G, Alderson, Mark R, Orme, Ian M
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antigens, Bacterial - immunology Applied microbiology Bacterial Proteins - administration & dosage Bacterial Proteins - immunology BCG Vaccine - administration & dosage BCG Vaccine - immunology Biological and medical sciences CD8-Positive T-Lymphocytes - immunology CD8-Positive T-Lymphocytes - metabolism Female Fundamental and applied biological sciences. Psychology Granzymes Interferon-gamma - metabolism Kinetics Liposomes Lung - cytology Lung - immunology Lung - metabolism Mice Mice, Inbred C57BL Microbial Immunity and Vaccines Microbiology Mycobacterium tuberculosis Mycobacterium tuberculosis - immunology Receptors, Interleukin-7 - metabolism Serine Endopeptidases - metabolism Tuberculosis, Pulmonary - immunology Tuberculosis, Pulmonary - prevention & control Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies (general aspects)
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