ASSOCIATION OF THE DOPAMINE TRANSPORTER GENE WITH ALCOHOLISM
Aims: It was investigated whether the allele A9 of the dopamine transporter gene (DAT1; SLC6A3) is associated with alcoholism, delirium tremens (DT), alcohol withdrawal seizures (AWS), or the daily alcohol intake. Methods: A group of 102 healthy subjects and 216 alcoholics, including 97 patients wit...
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| Veröffentlicht in: | Alcohol and alcoholism (Oxford) 2005-09, Vol.40 (5), p.339-342 |
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| container_title | Alcohol and alcoholism (Oxford) |
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| creator | KÖHNKE, MICHAEL D. BATRA, ANIL KOLB, WERNER KÖHNKE, ANNETTE M. LUTZ, ULRICH SCHICK, SANDRA GAERTNER, INES |
| description | Aims: It was investigated whether the allele A9 of the dopamine transporter gene (DAT1; SLC6A3) is associated with alcoholism, delirium tremens (DT), alcohol withdrawal seizures (AWS), or the daily alcohol intake. Methods: A group of 102 healthy subjects and 216 alcoholics, including 97 patients with a history of mild withdrawal symptoms, 65 with a history of AWS and 83 with a history of DT were genotyped and personal data were achieved for statistical evaluation in a case–control design. Results: The frequency of individuals carrying the allele A9 [f(A9+)] was significantly higher (P = 0.01) in the group of alcoholics [f(A9+) = 0.48] compared with healthy controls [f(A9+) = 0.32]. There was no significant association of the allele A9 with severe withdrawal symptoms or the daily amount of alcohol consumed. Conclusions: Our results reveal that the allele A9 is strongly associated with alcoholism but not with withdrawal symptoms or daily alcohol intake. |
| doi_str_mv | 10.1093/alcalc/agh179 |
| format | Article |
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Methods: A group of 102 healthy subjects and 216 alcoholics, including 97 patients with a history of mild withdrawal symptoms, 65 with a history of AWS and 83 with a history of DT were genotyped and personal data were achieved for statistical evaluation in a case–control design. Results: The frequency of individuals carrying the allele A9 [f(A9+)] was significantly higher (P = 0.01) in the group of alcoholics [f(A9+) = 0.48] compared with healthy controls [f(A9+) = 0.32]. There was no significant association of the allele A9 with severe withdrawal symptoms or the daily amount of alcohol consumed. Conclusions: Our results reveal that the allele A9 is strongly associated with alcoholism but not with withdrawal symptoms or daily alcohol intake.</description><identifier>ISSN: 0735-0414</identifier><identifier>EISSN: 1464-3502</identifier><identifier>DOI: 10.1093/alcalc/agh179</identifier><identifier>PMID: 15996968</identifier><language>eng</language><publisher>Oxford: Oxford University Press</publisher><subject>Adult ; Alcohol Drinking - genetics ; Alcohol Withdrawal Delirium - genetics ; Alcoholism - genetics ; Alcoholism and acute alcohol poisoning ; Biological and medical sciences ; Dopamine Plasma Membrane Transport Proteins - genetics ; Female ; Gene Frequency ; Genetic Carrier Screening ; Genetic Predisposition to Disease - genetics ; Genotype ; Humans ; Male ; Medical sciences ; Middle Aged ; Minisatellite Repeats - genetics ; Polymorphism, Genetic - genetics ; Reference Values ; Toxicology</subject><ispartof>Alcohol and alcoholism (Oxford), 2005-09, Vol.40 (5), p.339-342</ispartof><rights>2005 INIST-CNRS</rights><rights>Copyright Oxford University Press(England) Sep 2005</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c456t-ff8bca1196ab8f302157ea8e25aea7894628aded3089430019310006f0c323cc3</citedby><cites>FETCH-LOGICAL-c456t-ff8bca1196ab8f302157ea8e25aea7894628aded3089430019310006f0c323cc3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=17103150$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15996968$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>KÖHNKE, MICHAEL D.</creatorcontrib><creatorcontrib>BATRA, ANIL</creatorcontrib><creatorcontrib>KOLB, WERNER</creatorcontrib><creatorcontrib>KÖHNKE, ANNETTE M.</creatorcontrib><creatorcontrib>LUTZ, ULRICH</creatorcontrib><creatorcontrib>SCHICK, SANDRA</creatorcontrib><creatorcontrib>GAERTNER, INES</creatorcontrib><title>ASSOCIATION OF THE DOPAMINE TRANSPORTER GENE WITH ALCOHOLISM</title><title>Alcohol and alcoholism (Oxford)</title><addtitle>Alcohol and Alcoholism</addtitle><description>Aims: It was investigated whether the allele A9 of the dopamine transporter gene (DAT1; SLC6A3) is associated with alcoholism, delirium tremens (DT), alcohol withdrawal seizures (AWS), or the daily alcohol intake. Methods: A group of 102 healthy subjects and 216 alcoholics, including 97 patients with a history of mild withdrawal symptoms, 65 with a history of AWS and 83 with a history of DT were genotyped and personal data were achieved for statistical evaluation in a case–control design. Results: The frequency of individuals carrying the allele A9 [f(A9+)] was significantly higher (P = 0.01) in the group of alcoholics [f(A9+) = 0.48] compared with healthy controls [f(A9+) = 0.32]. There was no significant association of the allele A9 with severe withdrawal symptoms or the daily amount of alcohol consumed. Conclusions: Our results reveal that the allele A9 is strongly associated with alcoholism but not with withdrawal symptoms or daily alcohol intake.</description><subject>Adult</subject><subject>Alcohol Drinking - genetics</subject><subject>Alcohol Withdrawal Delirium - genetics</subject><subject>Alcoholism - genetics</subject><subject>Alcoholism and acute alcohol poisoning</subject><subject>Biological and medical sciences</subject><subject>Dopamine Plasma Membrane Transport Proteins - genetics</subject><subject>Female</subject><subject>Gene Frequency</subject><subject>Genetic Carrier Screening</subject><subject>Genetic Predisposition to Disease - genetics</subject><subject>Genotype</subject><subject>Humans</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Minisatellite Repeats - genetics</subject><subject>Polymorphism, Genetic - genetics</subject><subject>Reference Values</subject><subject>Toxicology</subject><issn>0735-0414</issn><issn>1464-3502</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2005</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpd0Ntr2zAUB2AxVto07eNehxmsb27Psawb7MW4bm1I45B4F_oiFEXe0uXSWgm0_31VEhooCCSkT-ccfoR8QbhEUPTKLGxYV-bvPxTqE-lhytOYMkg-kx4IymJIMT0hp94_AGBKEzwmJ8iU4orLHvmRTSZ1XmVNVQ-j-iZqyiK6rkfZXTUsomacDSejetwU4-i2CBe_q6aMskFel_WgmtydkaPWLLw73-998vOmaPIyHtS3VZ4NYpsyvonbVk6tQVTcTGVLIUEmnJEuYcYZIVXKE2lmbkYhnGmYUlEEAN6CpQm1lvbJxa7uY7d-2jq_0cu5t26xMCu33nqNIgXKgu2Tbx_gw3rbrcJsGpVMUEoUAcU7ZLu1951r9WM3X5ruRSPot0z1LlO9yzT4r_ui2-nSzQ56H2IA3_fA-PCx7czKzv3BCQSKDA6N537jnt_fTfdfc0EF0-Wfe_0Lr8cjfp9roK_sXYhU</recordid><startdate>20050901</startdate><enddate>20050901</enddate><creator>KÖHNKE, MICHAEL D.</creator><creator>BATRA, ANIL</creator><creator>KOLB, WERNER</creator><creator>KÖHNKE, ANNETTE M.</creator><creator>LUTZ, ULRICH</creator><creator>SCHICK, SANDRA</creator><creator>GAERTNER, INES</creator><general>Oxford University Press</general><general>Oxford Publishing Limited (England)</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QG</scope><scope>7TK</scope><scope>7U7</scope><scope>C1K</scope><scope>K9.</scope><scope>8FD</scope><scope>FR3</scope><scope>P64</scope><scope>RC3</scope></search><sort><creationdate>20050901</creationdate><title>ASSOCIATION OF THE DOPAMINE TRANSPORTER GENE WITH ALCOHOLISM</title><author>KÖHNKE, MICHAEL D. ; BATRA, ANIL ; KOLB, WERNER ; KÖHNKE, ANNETTE M. ; LUTZ, ULRICH ; SCHICK, SANDRA ; GAERTNER, INES</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c456t-ff8bca1196ab8f302157ea8e25aea7894628aded3089430019310006f0c323cc3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2005</creationdate><topic>Adult</topic><topic>Alcohol Drinking - genetics</topic><topic>Alcohol Withdrawal Delirium - genetics</topic><topic>Alcoholism - genetics</topic><topic>Alcoholism and acute alcohol poisoning</topic><topic>Biological and medical sciences</topic><topic>Dopamine Plasma Membrane Transport Proteins - genetics</topic><topic>Female</topic><topic>Gene Frequency</topic><topic>Genetic Carrier Screening</topic><topic>Genetic Predisposition to Disease - genetics</topic><topic>Genotype</topic><topic>Humans</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Minisatellite Repeats - genetics</topic><topic>Polymorphism, Genetic - genetics</topic><topic>Reference Values</topic><topic>Toxicology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>KÖHNKE, MICHAEL D.</creatorcontrib><creatorcontrib>BATRA, ANIL</creatorcontrib><creatorcontrib>KOLB, WERNER</creatorcontrib><creatorcontrib>KÖHNKE, ANNETTE M.</creatorcontrib><creatorcontrib>LUTZ, ULRICH</creatorcontrib><creatorcontrib>SCHICK, SANDRA</creatorcontrib><creatorcontrib>GAERTNER, INES</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Animal Behavior Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Toxicology Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><jtitle>Alcohol and alcoholism (Oxford)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>KÖHNKE, MICHAEL D.</au><au>BATRA, ANIL</au><au>KOLB, WERNER</au><au>KÖHNKE, ANNETTE M.</au><au>LUTZ, ULRICH</au><au>SCHICK, SANDRA</au><au>GAERTNER, INES</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>ASSOCIATION OF THE DOPAMINE TRANSPORTER GENE WITH ALCOHOLISM</atitle><jtitle>Alcohol and alcoholism (Oxford)</jtitle><addtitle>Alcohol and Alcoholism</addtitle><date>2005-09-01</date><risdate>2005</risdate><volume>40</volume><issue>5</issue><spage>339</spage><epage>342</epage><pages>339-342</pages><issn>0735-0414</issn><eissn>1464-3502</eissn><abstract>Aims: It was investigated whether the allele A9 of the dopamine transporter gene (DAT1; SLC6A3) is associated with alcoholism, delirium tremens (DT), alcohol withdrawal seizures (AWS), or the daily alcohol intake. Methods: A group of 102 healthy subjects and 216 alcoholics, including 97 patients with a history of mild withdrawal symptoms, 65 with a history of AWS and 83 with a history of DT were genotyped and personal data were achieved for statistical evaluation in a case–control design. Results: The frequency of individuals carrying the allele A9 [f(A9+)] was significantly higher (P = 0.01) in the group of alcoholics [f(A9+) = 0.48] compared with healthy controls [f(A9+) = 0.32]. There was no significant association of the allele A9 with severe withdrawal symptoms or the daily amount of alcohol consumed. Conclusions: Our results reveal that the allele A9 is strongly associated with alcoholism but not with withdrawal symptoms or daily alcohol intake.</abstract><cop>Oxford</cop><pub>Oxford University Press</pub><pmid>15996968</pmid><doi>10.1093/alcalc/agh179</doi><tpages>4</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Adult Alcohol Drinking - genetics Alcohol Withdrawal Delirium - genetics Alcoholism - genetics Alcoholism and acute alcohol poisoning Biological and medical sciences Dopamine Plasma Membrane Transport Proteins - genetics Female Gene Frequency Genetic Carrier Screening Genetic Predisposition to Disease - genetics Genotype Humans Male Medical sciences Middle Aged Minisatellite Repeats - genetics Polymorphism, Genetic - genetics Reference Values Toxicology |
| title | ASSOCIATION OF THE DOPAMINE TRANSPORTER GENE WITH ALCOHOLISM |
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