Effect of Chronic Angiotensin‐Converting Enzyme Inhibition on Striatal Dopamine Content in the MPTP‐Treated Mouse

: We have previously shown that chronic treatment with the angiotensin‐converting enzyme inhibitor perindopril increased striatal dopamine levels by 2.5‐fold in normal Sprague—Dawley rats, possibly via modulation of the striatal opioid or tachykinin levels. In the present study, we investigated if t...

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Veröffentlicht in:	Journal of neurochemistry 1999-07, Vol.73 (1), p.214-219
Hauptverfasser:	Jenkins, Trisha A., Wong, John Y. F., Howells, David W., Mendelsohn, Frederick A. O., Chai, Siew Yeen
Format:	Artikel
Sprache:	eng
Schlagworte:	1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine - administration & dosage 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine - pharmacology angiotensin-converting enzyme Angiotensin-Converting Enzyme Inhibitors - pharmacology Angiotensin‐converting enzyme inhibitor Animals Anticonvulsants. Antiepileptics. Antiparkinson agents Biological and medical sciences Corpus Striatum - drug effects Corpus Striatum - metabolism Disease Models, Animal Dopamine - metabolism Dopamine Agents - administration & dosage Dopamine Agents - pharmacology Indoles - administration & dosage Indoles - pharmacology Male Medical sciences Mice Mice, Inbred BALB C Mice, Inbred C57BL Neuropharmacology Parkinson Disease, Secondary - metabolism Parkinson’s disease Peptidyl-Dipeptidase A - blood Peptidyl-Dipeptidase A - metabolism Perindopril Pharmacology. Drug treatments Receptors, Dopamine D2 - metabolism Striatum
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