Induction of genetic damage in human lymphocytes and mutations in Salmonella by trihalomethanes: role of red blood cells and GSTT1-1 polymorphism

The brominated trihalomethanes (THMs) are mutagenic and carcinogenic disinfection by-products frequently found in chlorinated drinking water. They can be activated to mutagens by the product of the glutathione S-transferase-Θ (GSTT1-1) gene in Salmonella RSJ100, which has been transfected with this...

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Veröffentlicht in:	Mutagenesis 1999-09, Vol.14 (5), p.479-482
Hauptverfasser:	Landi, Stefano, Hanley, Nancy M., Warren, Sarah H., Pegram, Rex A., DeMarini, David M.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Animals Biological and medical sciences bromoform Carcinogens - toxicity Chlorofluorocarbons, Methane - toxicity DNA - drug effects DNA - genetics DNA Damage Dose-Response Relationship, Drug Environmental pollutants toxicology Erythrocytes - physiology Female Genotype glutathione transferase Glutathione Transferase - genetics GSTT1-1 protein GSTT11 protein Humans Hydrocarbons, Halogenated - toxicity Lymphocytes - cytology Lymphocytes - drug effects Lymphocytes - metabolism Male Medical sciences Microsomes, Liver - drug effects Middle Aged Mutagenicity Tests Mutation Polymorphism, Genetic Rats Rats, Sprague-Dawley Salmonella Salmonella typhimurium - drug effects Salmonella typhimurium - genetics Toxicology trihalomethane Trihalomethanes Water
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