Scrapie replication in lymphoid tissues depends on prion protein-expressing follicular dendritic cells

The immune system is central in the pathogenesis of scrapie and other transmissible spongiform encephalopathies (TSEs) or 'prion' diseases. After infecting by peripheral (intraperitoneal or oral) routes, most TSE agents replicate in spleen and lymph nodes before neuroinvasion. Characteriza...

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Veröffentlicht in:	Nature medicine 1999-11, Vol.5 (11), p.1308-1312
Hauptverfasser:	Brown, K.L, Stewart, K, Ritchie, D.L, Mabbott, N.A, Williams, A, Fraser, H, Morrison, W.I, Bruce, M.E
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Dendritic Cells, Follicular - immunology Dendritic Cells, Follicular - metabolism follicular dendritic cells Immunohistochemistry Lymphoid Tissue - immunology Lymphoid Tissue - metabolism Mice Mice, Knockout Mice, SCID PrPSc Proteins - biosynthesis Scrapie - immunology Scrapie - metabolism Tumor Necrosis Factor-alpha - genetics
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