Selective opioid δ agonists elicit antinociceptive supraspinal/spinal synergy in the rat

A multiplicative antinociceptive interaction of morphine activity at supraspinal and spinal sites has been clearly established and is thought to be responsible, in part, for the clinical utility of this compound in normal dose-ranges. While synergistic actions of μ-opioid receptor agonists have been...

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Veröffentlicht in:	Brain research 1999-10, Vol.843 (1), p.12-17
Hauptverfasser:	Kovelowski, Carl J., Bian, Di, J. Hruby, Victor, Lai, Josephine, Ossipov, Michael H., Porreca, Frank
Format:	Artikel
Sprache:	eng
Schlagworte:	[ d-Ala 2,Glu 4]deltorphin [ d-Pen 2, d-Pen 5]enkephalin Analgesics - pharmacology Animals Antinociception Biological and medical sciences Drug Synergism Enkephalin, D-Penicillamine (2,5)- - administration & dosage Enkephalin, D-Penicillamine (2,5)- - pharmacology Fundamental and applied biological sciences. Psychology Hot Temperature Injections, Spinal Male Medulla Oblongata - drug effects Medulla Oblongata - physiology Microinjections Oligopeptides - administration & dosage Oligopeptides - pharmacology Pain - physiopathology Rats Rats, Sprague-Dawley Receptors, Opioid, delta - agonists Rostral–ventral medulla Somesthesis and somesthetic pathways (proprioception, exteroception, nociception) interoception electrolocation. Sensory receptors Spinal Cord - drug effects Spinal Cord - physiology Supraspinal/spinal synergy Vertebrates: nervous system and sense organs δ-Opioid agonist
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