Long Chain CoA Esters as Competitive Antagonists of Phosphatidylinositol 4,5-Bisphosphate Activation in Kir Channels

Long chain fatty acid esters of coenzyme A (LC-CoA) are potent activators of ATP-sensitive (KATP) channels, and elevated levels have been implicated in the pathophysiology of type 2 diabetes. This stimulatory effect is thought to involve a mechanism similar to phosphatidylinositol 4,5-bisphosphate (...

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Veröffentlicht in:	The Journal of biological chemistry 2005-09, Vol.280 (35), p.30760-30767
Hauptverfasser:	Rapedius, Markus, Soom, Malle, Shumilina, Ekaterina, Schulze, Dirk, Schönherr, Roland, Kirsch, Cornelia, Lang, Florian, Tucker, Stephen J., Baukrowitz, Thomas
Format:	Artikel
Sprache:	eng
Schlagworte:	Acyl Coenzyme A - chemistry Acyl Coenzyme A - metabolism Animals Cell Line Esters - chemistry Esters - metabolism Humans Mice Molecular Structure Mutagenesis, Site-Directed Patch-Clamp Techniques Phosphatidylinositol 4,5-Diphosphate - metabolism Potassium Channels, Inwardly Rectifying - antagonists & inhibitors Potassium Channels, Inwardly Rectifying - genetics Potassium Channels, Inwardly Rectifying - metabolism Protein Isoforms - genetics Protein Isoforms - metabolism Rats Recombinant Fusion Proteins - genetics Recombinant Fusion Proteins - metabolism Serum Albumin, Bovine - metabolism
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