Potentiation of transmitter release from NMB human neuroblastoma cells by kappa-opioids is mediated by N-type voltage-dependent calcium channels
The selective kappa-opioid agonist trans-(±)-3,4-dichloro- N-methyl- N-[2-(1-pyrrolidinyl) cyclohexyl] benzenacetamidemethansulfonate (U50,488) potentiates both basal and depolarization-evoked [ 3 H] dopamine release from NMB cells. The potentiation of dopamine release by U50,488 is mediated by N-ty...
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| Veröffentlicht in: | Brain research 1999-10, Vol.843 (1), p.193-198 |
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| creator | Keren, Ora Gafni, Mikhal Sarne, Yosef |
| description | The selective kappa-opioid agonist trans-(±)-3,4-dichloro-
N-methyl-
N-[2-(1-pyrrolidinyl) cyclohexyl] benzenacetamidemethansulfonate (U50,488) potentiates both basal and depolarization-evoked
[
3
H]
dopamine release from NMB cells. The potentiation of dopamine release by U50,488 is mediated by N-type voltage-dependent calcium channels since it is blocked by omega-conotoxin, and is resistant to pertussis toxin (PTX)-treatment. When the stimulation of release by U50,488 is blocked by the N-channel antagonist omega-conotoxin, an inhibitory effect on dopamine release is revealed, suggesting that stimulatory and inhibitory effects of U50,488 are exerted in parallel. |
| doi_str_mv | 10.1016/S0006-8993(99)01904-6 |
| format | Article |
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N-methyl-
N-[2-(1-pyrrolidinyl) cyclohexyl] benzenacetamidemethansulfonate (U50,488) potentiates both basal and depolarization-evoked
[
3
H]
dopamine release from NMB cells. The potentiation of dopamine release by U50,488 is mediated by N-type voltage-dependent calcium channels since it is blocked by omega-conotoxin, and is resistant to pertussis toxin (PTX)-treatment. When the stimulation of release by U50,488 is blocked by the N-channel antagonist omega-conotoxin, an inhibitory effect on dopamine release is revealed, suggesting that stimulatory and inhibitory effects of U50,488 are exerted in parallel.</description><identifier>ISSN: 0006-8993</identifier><identifier>EISSN: 1872-6240</identifier><identifier>DOI: 10.1016/S0006-8993(99)01904-6</identifier><identifier>PMID: 10528125</identifier><identifier>CODEN: BRREAP</identifier><language>eng</language><publisher>London: Elsevier B.V</publisher><subject>3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer - pharmacology ; Analgesics - pharmacology ; Biological and medical sciences ; Calcium Channel Blockers - pharmacology ; Calcium Channels, N-Type - drug effects ; Calcium Channels, N-Type - physiology ; Cell physiology ; Dopamine - metabolism ; Enkephalin, D-Penicillamine (2,5)- - pharmacology ; Enkephalin, Leucine - analogs & derivatives ; Enkephalin, Leucine - pharmacology ; Fundamental and applied biological sciences. Psychology ; Humans ; Kappa-opioid receptor ; Molecular and cellular biology ; Neuroblastoma ; Neurotransmission ; NMB neuroblastoma cell line ; omega-Conotoxins - pharmacology ; Opiate ; Pertussis Toxin ; Potassium Cyanide - pharmacology ; Receptors, Opioid, kappa - agonists ; Transmitter release ; Tumor Cells, Cultured ; Virulence Factors, Bordetella - pharmacology ; Voltage-dependent calcium channel ; w-Conotoxin</subject><ispartof>Brain research, 1999-10, Vol.843 (1), p.193-198</ispartof><rights>1999 Elsevier Science B.V.</rights><rights>1999 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c421t-49dab5b12472024826e6a1f007b9a2231ab3068df457c197ded4fe49ea4eb64f3</citedby><cites>FETCH-LOGICAL-c421t-49dab5b12472024826e6a1f007b9a2231ab3068df457c197ded4fe49ea4eb64f3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/S0006-8993(99)01904-6$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,777,781,3537,27905,27906,45976</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=1971210$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/10528125$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Keren, Ora</creatorcontrib><creatorcontrib>Gafni, Mikhal</creatorcontrib><creatorcontrib>Sarne, Yosef</creatorcontrib><title>Potentiation of transmitter release from NMB human neuroblastoma cells by kappa-opioids is mediated by N-type voltage-dependent calcium channels</title><title>Brain research</title><addtitle>Brain Res</addtitle><description>The selective kappa-opioid agonist trans-(±)-3,4-dichloro-
N-methyl-
N-[2-(1-pyrrolidinyl) cyclohexyl] benzenacetamidemethansulfonate (U50,488) potentiates both basal and depolarization-evoked
[
3
H]
dopamine release from NMB cells. The potentiation of dopamine release by U50,488 is mediated by N-type voltage-dependent calcium channels since it is blocked by omega-conotoxin, and is resistant to pertussis toxin (PTX)-treatment. When the stimulation of release by U50,488 is blocked by the N-channel antagonist omega-conotoxin, an inhibitory effect on dopamine release is revealed, suggesting that stimulatory and inhibitory effects of U50,488 are exerted in parallel.</description><subject>3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer - pharmacology</subject><subject>Analgesics - pharmacology</subject><subject>Biological and medical sciences</subject><subject>Calcium Channel Blockers - pharmacology</subject><subject>Calcium Channels, N-Type - drug effects</subject><subject>Calcium Channels, N-Type - physiology</subject><subject>Cell physiology</subject><subject>Dopamine - metabolism</subject><subject>Enkephalin, D-Penicillamine (2,5)- - pharmacology</subject><subject>Enkephalin, Leucine - analogs & derivatives</subject><subject>Enkephalin, Leucine - pharmacology</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Humans</subject><subject>Kappa-opioid receptor</subject><subject>Molecular and cellular biology</subject><subject>Neuroblastoma</subject><subject>Neurotransmission</subject><subject>NMB neuroblastoma cell line</subject><subject>omega-Conotoxins - pharmacology</subject><subject>Opiate</subject><subject>Pertussis Toxin</subject><subject>Potassium Cyanide - pharmacology</subject><subject>Receptors, Opioid, kappa - agonists</subject><subject>Transmitter release</subject><subject>Tumor Cells, Cultured</subject><subject>Virulence Factors, Bordetella - pharmacology</subject><subject>Voltage-dependent calcium channel</subject><subject>w-Conotoxin</subject><issn>0006-8993</issn><issn>1872-6240</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1999</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkU1vFSEUhomxsdfqT9CwMEYXo8AwH6wabdQ2qdVEXZMzcMaiMzAC0-T-C3-y3N4bddcVITzng-cl5Alnrzjj7esvjLG26pWqXyj1knHFZNXeIxved6JqhWT3yeYvckwepvSjXOtasQfkmLNG9Fw0G_L7c8jos4PsgqdhpDmCT7PLGSONOCEkpGMMM736-JZerzN46nGNYZgg5TADNThNiQ5b-hOWBaqwuOBsoi7RGW3pi3b3eFXl7YL0JkwZvmNlcUFvy2BqYDJunam5Bu9xSo_I0QhTwseH84R8e__u69l5dfnpw8XZm8vKSMFzJZWFoRm4kJ1gQvaixRb4yFg3KBCi5jDUrO3tKJvOcNVZtHJEqRAkDq0c6xPyfN93ieHXiinr2aXdX8BjWJPmXa16IUUBmz1oYkgp4qiX6GaIW82Z3kWhb6PQO89aKX0bhW5L3dPDgHUoJv6r2rsvwLMDAKlYGIt449I_TnVccFaw0z1W5OCNw6iTcehNkRvRZG2Du2OTPyVuqDE</recordid><startdate>19991002</startdate><enddate>19991002</enddate><creator>Keren, Ora</creator><creator>Gafni, Mikhal</creator><creator>Sarne, Yosef</creator><general>Elsevier B.V</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QP</scope><scope>7TK</scope></search><sort><creationdate>19991002</creationdate><title>Potentiation of transmitter release from NMB human neuroblastoma cells by kappa-opioids is mediated by N-type voltage-dependent calcium channels</title><author>Keren, Ora ; Gafni, Mikhal ; Sarne, Yosef</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c421t-49dab5b12472024826e6a1f007b9a2231ab3068df457c197ded4fe49ea4eb64f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1999</creationdate><topic>3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer - pharmacology</topic><topic>Analgesics - pharmacology</topic><topic>Biological and medical sciences</topic><topic>Calcium Channel Blockers - pharmacology</topic><topic>Calcium Channels, N-Type - drug effects</topic><topic>Calcium Channels, N-Type - physiology</topic><topic>Cell physiology</topic><topic>Dopamine - metabolism</topic><topic>Enkephalin, D-Penicillamine (2,5)- - pharmacology</topic><topic>Enkephalin, Leucine - analogs & derivatives</topic><topic>Enkephalin, Leucine - pharmacology</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Humans</topic><topic>Kappa-opioid receptor</topic><topic>Molecular and cellular biology</topic><topic>Neuroblastoma</topic><topic>Neurotransmission</topic><topic>NMB neuroblastoma cell line</topic><topic>omega-Conotoxins - pharmacology</topic><topic>Opiate</topic><topic>Pertussis Toxin</topic><topic>Potassium Cyanide - pharmacology</topic><topic>Receptors, Opioid, kappa - agonists</topic><topic>Transmitter release</topic><topic>Tumor Cells, Cultured</topic><topic>Virulence Factors, Bordetella - pharmacology</topic><topic>Voltage-dependent calcium channel</topic><topic>w-Conotoxin</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Keren, Ora</creatorcontrib><creatorcontrib>Gafni, Mikhal</creatorcontrib><creatorcontrib>Sarne, Yosef</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Neurosciences Abstracts</collection><jtitle>Brain research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Keren, Ora</au><au>Gafni, Mikhal</au><au>Sarne, Yosef</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Potentiation of transmitter release from NMB human neuroblastoma cells by kappa-opioids is mediated by N-type voltage-dependent calcium channels</atitle><jtitle>Brain research</jtitle><addtitle>Brain Res</addtitle><date>1999-10-02</date><risdate>1999</risdate><volume>843</volume><issue>1</issue><spage>193</spage><epage>198</epage><pages>193-198</pages><issn>0006-8993</issn><eissn>1872-6240</eissn><coden>BRREAP</coden><abstract>The selective kappa-opioid agonist trans-(±)-3,4-dichloro-
N-methyl-
N-[2-(1-pyrrolidinyl) cyclohexyl] benzenacetamidemethansulfonate (U50,488) potentiates both basal and depolarization-evoked
[
3
H]
dopamine release from NMB cells. The potentiation of dopamine release by U50,488 is mediated by N-type voltage-dependent calcium channels since it is blocked by omega-conotoxin, and is resistant to pertussis toxin (PTX)-treatment. When the stimulation of release by U50,488 is blocked by the N-channel antagonist omega-conotoxin, an inhibitory effect on dopamine release is revealed, suggesting that stimulatory and inhibitory effects of U50,488 are exerted in parallel.</abstract><cop>London</cop><cop>Amsterdam</cop><cop>New York, NY</cop><pub>Elsevier B.V</pub><pmid>10528125</pmid><doi>10.1016/S0006-8993(99)01904-6</doi><tpages>6</tpages></addata></record> |
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| subjects | 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer - pharmacology Analgesics - pharmacology Biological and medical sciences Calcium Channel Blockers - pharmacology Calcium Channels, N-Type - drug effects Calcium Channels, N-Type - physiology Cell physiology Dopamine - metabolism Enkephalin, D-Penicillamine (2,5)- - pharmacology Enkephalin, Leucine - analogs & derivatives Enkephalin, Leucine - pharmacology Fundamental and applied biological sciences. Psychology Humans Kappa-opioid receptor Molecular and cellular biology Neuroblastoma Neurotransmission NMB neuroblastoma cell line omega-Conotoxins - pharmacology Opiate Pertussis Toxin Potassium Cyanide - pharmacology Receptors, Opioid, kappa - agonists Transmitter release Tumor Cells, Cultured Virulence Factors, Bordetella - pharmacology Voltage-dependent calcium channel w-Conotoxin |
| title | Potentiation of transmitter release from NMB human neuroblastoma cells by kappa-opioids is mediated by N-type voltage-dependent calcium channels |
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