Superoxide Radical Formation by Pure Complex I (NADH:Ubiquinone Oxidoreductase) from Yarrowia lipolytica

Generation of reactive oxygen species (ROS) is increasingly recognized as an important cellular process involved in numerous physiological and pathophysiological processes. Complex I (NADH:ubiquinone oxidoreductase) is considered as one of the major sources of ROS within mitochondria. Yet, the exact...

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Veröffentlicht in:	The Journal of biological chemistry 2005-08, Vol.280 (34), p.30129-30135
Hauptverfasser:	Galkin, Alexander, Brandt, Ulrich
Format:	Artikel
Sprache:	eng
Schlagworte:	Catalysis Dose-Response Relationship, Drug Electron Transport Complex I - metabolism Electrons Hydrogen-Ion Concentration Mitochondria - metabolism NAD - chemistry NAD - metabolism Oxidation-Reduction Oxygen - metabolism Point Mutation Proteolipids - metabolism Quinones - chemistry Reactive Oxygen Species Superoxides - metabolism Ubiquinone - metabolism Yarrowia - enzymology Yarrowia - metabolism Yarrowia lipolytica
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