Failure of preventive effects of 2-deoxy- d-glucose on ischemia-induced gerbil hippocampal neuronal damage by induced hyperthermia

Post-ischemic administration of 2-deoxy- d-glucose (2-DG), a glucose antimetabolite, markedly reduces the occurrence of ischemia-induced delayed neuronal death (DND) in the gerbil hippocampus. This means that the reduction of energy dependent metabolism after ischemia prevents ischemia-induced damag...

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Veröffentlicht in:	Brain research 1999-09, Vol.840 (1), p.167-170
Hauptverfasser:	Hara, Akira, Niwa, Masayuki, Iwai, Tomohiko, Yano, Hirohito, Nakashima, Masaya, Bunai, Yasuo, Uematsu, Toshihiko, Yoshimi, Naoki, Mori, Hideki
Format:	Artikel
Sprache:	eng
Schlagworte:	2-Deoxy- d-glucose Animals Antimetabolites - pharmacology Biological and medical sciences Delayed neuronal death Deoxyglucose - pharmacology DNA fragmentation Gerbil Gerbillinae Hippocampus - pathology Hyperthermia Hyperthermia, Induced Ischemic Attack, Transient - pathology Male Medical sciences Meriones unguiculatus Neurology Neurons - drug effects Neurons - pathology Vascular diseases and vascular malformations of the nervous system
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