Metallothionein modulates the carcinogenicity of N-butyl-N-(4-hydroxybutyl)nitrosamine in mice

We examined the carcinogenicity of N-butyl-N-(4-hydroxybutyl)nitrosamine (BBN) in transgenic mice deficient in the metallothionein (MT) I and II genes and in control (129/Sv) mice. Both strains of mice were given BBN for 8 weeks with or without Zn treatment. All mice were killed at 12 weeks after th...

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Veröffentlicht in:	Carcinogenesis (New York) 1999-08, Vol.20 (8), p.1625-1628
Hauptverfasser:	Kondo, Yukihiro, Himeno, Seiichiro, Endo, Wakako, Mita, Masaharu, Suzuki, Yasutomo, Nemoto, Kaoru, Akimoto, Masao, Lazo, John S., Imura, Nobumasa
Format:	Artikel
Sprache:	eng
Schlagworte:	12-dimethylbenz[a]anthracene Animals BBN Biological and medical sciences Butylhydroxybutylnitrosamine - pharmacology Butylhydroxybutylnitrosamine - toxicity Carcinogenesis, carcinogens and anticarcinogens Carcinogenicity Tests Carcinogens - antagonists & inhibitors Carcinogens - toxicity Carcinoma, Transitional Cell - chemically induced Carcinoma, Transitional Cell - metabolism Chemical agents Chlorides - pharmacology DMBA Medical sciences metallothionein Metallothionein - deficiency Metallothionein - drug effects Metallothionein - physiology Mice Mice, Transgenic N-Butyl-N-(4-hydroxybutyl)nitrosamine Tumors Urinary Bladder Neoplasms - chemically induced Urinary Bladder Neoplasms - metabolism Urinary Bladder Neoplasms - pathology Zinc Compounds - pharmacology
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