Duration effect of Acacia nilotica leaves extract and glibenclamide as hypolipidaemic and hypoglycaemic activity in alloxan induced diabetic rats
To compare the duration and effects of aqueous methanol Acacia-nilotica leaves extract and glibenclamide as hypoglycaemic and hypolipidaemic activity in diabetic rats. The experimental study was conducted at Shifa International Hospital in collaboration with National Institute of Health, Islamabad,...
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| Veröffentlicht in: | Journal of the Pakistan Medical Association 2015-12, Vol.65 (12), p.1266-1270 |
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| container_title | Journal of the Pakistan Medical Association |
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| creator | Asad, Munazza Munir, Tahir Ahmad Farid, Sadaf Aslam, Muhammad Shah, Syed Shoaib |
| description | To compare the duration and effects of aqueous methanol Acacia-nilotica leaves extract and glibenclamide as hypoglycaemic and hypolipidaemic activity in diabetic rats.
The experimental study was conducted at Shifa International Hospital in collaboration with National Institute of Health, Islamabad, from September 2010 to August 2011.Male Sprague Dawley albino rats were taken and divided into 8 equal groups. Groups I and II were the normal and diabetic control rats. Diabetes mellitus was induced in group II to VIII by administering 110 mg/kg body weight alloxanand at day 4, fasting blood glucose level of >200 mg/dl confirmed diabetes. Acacia-nilotica leaves extract was given to group III, IV and V and glibenclamide to group VI to VIII for a period of 1-3 weeks. Blood samples were analysed for lipid profile using enzymatic calorimetric method and serum insulin by enzyme-linked immunosorbent assay on days 0, 7, 14, and 21.
There were 64 rats in the study, with 8(12.5%) in each group. Statistically significant decreases in fasting blood glucose, total cholesterol, triglyceride, phospholipids, low density lipoprotein, very low density lipoprotein and an increase in high density lipoprotein and serum insulin levels were observed in diabetic rats compared to diabetic controls after 2 weeks of treatment with plant extract and glibenclamide (p |
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The experimental study was conducted at Shifa International Hospital in collaboration with National Institute of Health, Islamabad, from September 2010 to August 2011.Male Sprague Dawley albino rats were taken and divided into 8 equal groups. Groups I and II were the normal and diabetic control rats. Diabetes mellitus was induced in group II to VIII by administering 110 mg/kg body weight alloxanand at day 4, fasting blood glucose level of >200 mg/dl confirmed diabetes. Acacia-nilotica leaves extract was given to group III, IV and V and glibenclamide to group VI to VIII for a period of 1-3 weeks. Blood samples were analysed for lipid profile using enzymatic calorimetric method and serum insulin by enzyme-linked immunosorbent assay on days 0, 7, 14, and 21.
There were 64 rats in the study, with 8(12.5%) in each group. Statistically significant decreases in fasting blood glucose, total cholesterol, triglyceride, phospholipids, low density lipoprotein, very low density lipoprotein and an increase in high density lipoprotein and serum insulin levels were observed in diabetic rats compared to diabetic controls after 2 weeks of treatment with plant extract and glibenclamide (p<0.05 each).When plant extract and drug treated diabetic rats were compared, a significant difference in the levels of blood glucose, insulin, total cholesterol and triglyceride levels were noted after 2 and 3 weeks of treatment.
Acacia-nilotica leaves extract resulted in hypoglycaemic and hypolipidaemic effect in alloxan-induced diabetic rats similar to glibenclamide.</description><identifier>ISSN: 0030-9982</identifier><identifier>PMID: 26627505</identifier><language>eng</language><publisher>Pakistan: Knowledge Bylanes</publisher><subject>Acacia ; Alloxan ; Animals ; Body weight ; Complications and side effects ; Diabetes Mellitus, Experimental - blood ; Diabetes Mellitus, Experimental - drug therapy ; Diabetes therapy ; Glyburide ; Glyburide - therapeutic use ; Herbal medicine ; Hypoglycemic Agents - therapeutic use ; Lipids - blood ; Male ; Phytotherapy ; Plant Extracts - therapeutic use ; Plant Leaves ; Pyrimidines ; Rats ; Rats, Sprague-Dawley ; Type 2 diabetes</subject><ispartof>Journal of the Pakistan Medical Association, 2015-12, Vol.65 (12), p.1266-1270</ispartof><rights>COPYRIGHT 2015 Knowledge Bylanes</rights><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26627505$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Asad, Munazza</creatorcontrib><creatorcontrib>Munir, Tahir Ahmad</creatorcontrib><creatorcontrib>Farid, Sadaf</creatorcontrib><creatorcontrib>Aslam, Muhammad</creatorcontrib><creatorcontrib>Shah, Syed Shoaib</creatorcontrib><title>Duration effect of Acacia nilotica leaves extract and glibenclamide as hypolipidaemic and hypoglycaemic activity in alloxan induced diabetic rats</title><title>Journal of the Pakistan Medical Association</title><addtitle>J Pak Med Assoc</addtitle><description>To compare the duration and effects of aqueous methanol Acacia-nilotica leaves extract and glibenclamide as hypoglycaemic and hypolipidaemic activity in diabetic rats.
The experimental study was conducted at Shifa International Hospital in collaboration with National Institute of Health, Islamabad, from September 2010 to August 2011.Male Sprague Dawley albino rats were taken and divided into 8 equal groups. Groups I and II were the normal and diabetic control rats. Diabetes mellitus was induced in group II to VIII by administering 110 mg/kg body weight alloxanand at day 4, fasting blood glucose level of >200 mg/dl confirmed diabetes. Acacia-nilotica leaves extract was given to group III, IV and V and glibenclamide to group VI to VIII for a period of 1-3 weeks. Blood samples were analysed for lipid profile using enzymatic calorimetric method and serum insulin by enzyme-linked immunosorbent assay on days 0, 7, 14, and 21.
There were 64 rats in the study, with 8(12.5%) in each group. Statistically significant decreases in fasting blood glucose, total cholesterol, triglyceride, phospholipids, low density lipoprotein, very low density lipoprotein and an increase in high density lipoprotein and serum insulin levels were observed in diabetic rats compared to diabetic controls after 2 weeks of treatment with plant extract and glibenclamide (p<0.05 each).When plant extract and drug treated diabetic rats were compared, a significant difference in the levels of blood glucose, insulin, total cholesterol and triglyceride levels were noted after 2 and 3 weeks of treatment.
Acacia-nilotica leaves extract resulted in hypoglycaemic and hypolipidaemic effect in alloxan-induced diabetic rats similar to glibenclamide.</description><subject>Acacia</subject><subject>Alloxan</subject><subject>Animals</subject><subject>Body weight</subject><subject>Complications and side effects</subject><subject>Diabetes Mellitus, Experimental - blood</subject><subject>Diabetes Mellitus, Experimental - drug therapy</subject><subject>Diabetes therapy</subject><subject>Glyburide</subject><subject>Glyburide - therapeutic use</subject><subject>Herbal medicine</subject><subject>Hypoglycemic Agents - therapeutic use</subject><subject>Lipids - blood</subject><subject>Male</subject><subject>Phytotherapy</subject><subject>Plant Extracts - therapeutic use</subject><subject>Plant Leaves</subject><subject>Pyrimidines</subject><subject>Rats</subject><subject>Rats, Sprague-Dawley</subject><subject>Type 2 diabetes</subject><issn>0030-9982</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNptkc1q4zAQx31o2aTdfYVFUCi9pCiyLVvH0G8o9NI9m7E0SqbIUmrJpXmMfePamxS2UGZghj-_-WDmKJtznvOFUrWYZScxvnAuZMn5j2wmpBRVyct59vd66CFR8AytRZ1YsGylQRMwTy4k0sAcwhtGhu-ph5EAb9jaUYteO-jIIIPINrttcLQlA9iR_sdM0trt9EHRid4o7Rh5Bs6Fd_BjagaNhhmCFsdRbFwl_syOLbiIvw7xNPtze_N8db94fLp7uFo9LtY5V2nRlkqA0ljlRQulqUuDrdWaYyG0rGUlleRcSyNyVRd2KQqrtAUUFqS1lSzy0-xi33fbh9cBY2o6ihqdA49hiM2yyut6Oboa0bM9ugaHDXkbpktMeLMqylwslRBTw8tvqNHMdIDg0dKofyk4_69gg-DSJgY3TO-IX8Hfh1WHtkPTbHvqoN81n2_MPwCp8plP</recordid><startdate>20151201</startdate><enddate>20151201</enddate><creator>Asad, Munazza</creator><creator>Munir, Tahir Ahmad</creator><creator>Farid, Sadaf</creator><creator>Aslam, Muhammad</creator><creator>Shah, Syed Shoaib</creator><general>Knowledge Bylanes</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope></search><sort><creationdate>20151201</creationdate><title>Duration effect of Acacia nilotica leaves extract and glibenclamide as hypolipidaemic and hypoglycaemic activity in alloxan induced diabetic rats</title><author>Asad, Munazza ; Munir, Tahir Ahmad ; Farid, Sadaf ; Aslam, Muhammad ; Shah, Syed Shoaib</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-g309t-b592a9ce734ba5d85debfcc0e42c686769600c6d23984f124f9cfae2fa6ff7643</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Acacia</topic><topic>Alloxan</topic><topic>Animals</topic><topic>Body weight</topic><topic>Complications and side effects</topic><topic>Diabetes Mellitus, Experimental - blood</topic><topic>Diabetes Mellitus, Experimental - drug therapy</topic><topic>Diabetes therapy</topic><topic>Glyburide</topic><topic>Glyburide - therapeutic use</topic><topic>Herbal medicine</topic><topic>Hypoglycemic Agents - therapeutic use</topic><topic>Lipids - blood</topic><topic>Male</topic><topic>Phytotherapy</topic><topic>Plant Extracts - therapeutic use</topic><topic>Plant Leaves</topic><topic>Pyrimidines</topic><topic>Rats</topic><topic>Rats, Sprague-Dawley</topic><topic>Type 2 diabetes</topic><toplevel>online_resources</toplevel><creatorcontrib>Asad, Munazza</creatorcontrib><creatorcontrib>Munir, Tahir Ahmad</creatorcontrib><creatorcontrib>Farid, Sadaf</creatorcontrib><creatorcontrib>Aslam, Muhammad</creatorcontrib><creatorcontrib>Shah, Syed Shoaib</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of the Pakistan Medical Association</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Asad, Munazza</au><au>Munir, Tahir Ahmad</au><au>Farid, Sadaf</au><au>Aslam, Muhammad</au><au>Shah, Syed Shoaib</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Duration effect of Acacia nilotica leaves extract and glibenclamide as hypolipidaemic and hypoglycaemic activity in alloxan induced diabetic rats</atitle><jtitle>Journal of the Pakistan Medical Association</jtitle><addtitle>J Pak Med Assoc</addtitle><date>2015-12-01</date><risdate>2015</risdate><volume>65</volume><issue>12</issue><spage>1266</spage><epage>1270</epage><pages>1266-1270</pages><issn>0030-9982</issn><abstract>To compare the duration and effects of aqueous methanol Acacia-nilotica leaves extract and glibenclamide as hypoglycaemic and hypolipidaemic activity in diabetic rats.
The experimental study was conducted at Shifa International Hospital in collaboration with National Institute of Health, Islamabad, from September 2010 to August 2011.Male Sprague Dawley albino rats were taken and divided into 8 equal groups. Groups I and II were the normal and diabetic control rats. Diabetes mellitus was induced in group II to VIII by administering 110 mg/kg body weight alloxanand at day 4, fasting blood glucose level of >200 mg/dl confirmed diabetes. Acacia-nilotica leaves extract was given to group III, IV and V and glibenclamide to group VI to VIII for a period of 1-3 weeks. Blood samples were analysed for lipid profile using enzymatic calorimetric method and serum insulin by enzyme-linked immunosorbent assay on days 0, 7, 14, and 21.
There were 64 rats in the study, with 8(12.5%) in each group. Statistically significant decreases in fasting blood glucose, total cholesterol, triglyceride, phospholipids, low density lipoprotein, very low density lipoprotein and an increase in high density lipoprotein and serum insulin levels were observed in diabetic rats compared to diabetic controls after 2 weeks of treatment with plant extract and glibenclamide (p<0.05 each).When plant extract and drug treated diabetic rats were compared, a significant difference in the levels of blood glucose, insulin, total cholesterol and triglyceride levels were noted after 2 and 3 weeks of treatment.
Acacia-nilotica leaves extract resulted in hypoglycaemic and hypolipidaemic effect in alloxan-induced diabetic rats similar to glibenclamide.</abstract><cop>Pakistan</cop><pub>Knowledge Bylanes</pub><pmid>26627505</pmid><tpages>5</tpages></addata></record> |
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| source | MEDLINE; DOAJ Directory of Open Access Journals; EZB-FREE-00999 freely available EZB journals |
| subjects | Acacia Alloxan Animals Body weight Complications and side effects Diabetes Mellitus, Experimental - blood Diabetes Mellitus, Experimental - drug therapy Diabetes therapy Glyburide Glyburide - therapeutic use Herbal medicine Hypoglycemic Agents - therapeutic use Lipids - blood Male Phytotherapy Plant Extracts - therapeutic use Plant Leaves Pyrimidines Rats Rats, Sprague-Dawley Type 2 diabetes |
| title | Duration effect of Acacia nilotica leaves extract and glibenclamide as hypolipidaemic and hypoglycaemic activity in alloxan induced diabetic rats |
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