Melanocytes are more responsive to IFN-γ and produce higher amounts of kynurenine than melanoma cells

A key link between amino acid catabolism and immune regulation in cancer is the augmented tryptophan (Trp) catabolism through the kynurenine pathway (KP), a metabolic route induced by interferon-γ (IFN-γ) and related to poor prognosis in melanomas. Besides its role in cancer, IFN-γ plays a key role...

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Veröffentlicht in:	Biological chemistry 2016-01, Vol.397 (1), p.85-90
Hauptverfasser:	Clara, Renan Orsati, Assmann, Nadine, Ramos Moreno, Ana Carolina, Coimbra, Janine Baptista, Nurenberger, Nadine, Dettmer-Wilde, Katja, Oefner, Peter Josef, Campa, Ana
Format:	Artikel
Sprache:	eng
Schlagworte:	Cell Line, Tumor Humans Interferon-gamma - metabolism interferon-γ Kynurenine - biosynthesis melanocytes Melanocytes - metabolism melanoma Melanoma - metabolism Melanoma - pathology metabolism tryptophan
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description	A key link between amino acid catabolism and immune regulation in cancer is the augmented tryptophan (Trp) catabolism through the kynurenine pathway (KP), a metabolic route induced by interferon-γ (IFN-γ) and related to poor prognosis in melanomas. Besides its role in cancer, IFN-γ plays a key role in the control of pigmentation homeostasis. Here we measured KP metabolites in human melanoma lines and skin melanocytes and fibroblasts in response to IFN-γ. In general, IFN-γ affected KP in skin cells more than in melanoma cells, supporting IFN-γ roles in skin physiology and that of stromal cells in modulating the tumor microenvironment.
doi_str_mv	10.1515/hsz-2015-0173
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subjects	Cell Line, Tumor Humans Interferon-gamma - metabolism interferon-γ Kynurenine - biosynthesis melanocytes Melanocytes - metabolism melanoma Melanoma - metabolism Melanoma - pathology metabolism tryptophan
title	Melanocytes are more responsive to IFN-γ and produce higher amounts of kynurenine than melanoma cells
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