Disease-Specific Survival with Spindle Cell Carcinoma of the Head and Neck
Objectives (1) Determine factors influencing survival in patients diagnosed with spindle cell carcinoma (SpCC), a rare variant of head and neck squamous cell carcinoma (SCC). (2) Compare survival of patients with SpCC to those with conventional SCC. Study Design Retrospective cohort study. Setting S...
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| Veröffentlicht in: | Otolaryngology-head and neck surgery 2015-12, Vol.153 (6), p.973-980 |
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| creator | Bice, Tristan C. Tran, Van Merkley, Mark A. Newlands, Shawn D. van der Sloot, Paul G. Wu, Shuang Miller, Matthew C. |
| description | Objectives
(1) Determine factors influencing survival in patients diagnosed with spindle cell carcinoma (SpCC), a rare variant of head and neck squamous cell carcinoma (SCC). (2) Compare survival of patients with SpCC to those with conventional SCC.
Study Design
Retrospective cohort study.
Setting
Surveillance, Epidemiology, and End Results 18 database (years 2004-2009).
Subjects and Methods
Among patients receiving treatment for a single primary in the oral cavity, oropharynx, hypopharynx, or larynx, 118 subjects with SpCC and 18,298 subjects with SCC were identified with complete data for the variables of age, sex, grade, tumor size, stage group, and TNM stage. Disease-specific survival curves were compared. Univariate and multivariate analyses were used to examine the effects of each factor on survival over all sites and within each of 3 sites.
Results
Univariate analysis of the combination of the 3 anatomic subsites showed survival with SpCC was worse than with conventional SCC (P < .001). Three-year disease-specific survival with SpCC was 49.5%, and 5-year disease-specific survival was 40.2%. Compared with conventional SCC, survival was worse for SpCC of the oral cavity (P < .001) and oropharynx (P < .001) but no different for the larynx and hypopharynx site (P = .15). Multivariate analysis identified age (P = .02), tumor size (P = .006), and M stage (P < .001) as the only variables significantly affecting survival with SpCC. All variables significantly affected survival with conventional SCC.
Conclusions
Spindle cell carcinoma carries a worse prognosis than SCC. Larger tumor size, older age, and metastatic disease portend worse survival with SpCC of the head and neck. |
| doi_str_mv | 10.1177/0194599815594360 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1738814343</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sage_id>10.1177_0194599815594360</sage_id><sourcerecordid>1738814343</sourcerecordid><originalsourceid>FETCH-LOGICAL-c3866-5a9f5c1458f24b4e3fc0682f5808f3574055f24cd67eab1781245965c3feba373</originalsourceid><addsrcrecordid>eNqFkL1PwzAUxC0EoqWwMyGPLAE7jj8yQqEUVLVDYY4c55m65KPETav-96RKYUBCTG-4-53uHUKXlNxQKuUtoXHE41hRzuOICXKE-pTEMhCKymPU38vBXu-hM--XhBAhpDxFvVCEhBHF--jlwXnQHoL5CoyzzuB5U2_cRud469YLPF-5MssBDyHP8VDXxpVVoXFl8XoBeAw6w7rM8BTMxzk6sTr3cHG4A_Q2enwdjoPJ7Ol5eDcJDFNCBFzHlhsacWXDKI2AWUOECi1XRFnGZUQ4bxWTCQk6pVLRsP1RcMMspJpJNkDXXe6qrj4b8OukcN60_XQJVeMTKplSNGIRa62ks5q68r4Gm6xqV-h6l1CS7BdMfi_YIleH9CYtIPsBvidrDaozbF0Ou38Dk9l4ej8iklPRokGHev0OybJq6rId6u8uX9nGhf8</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1738814343</pqid></control><display><type>article</type><title>Disease-Specific Survival with Spindle Cell Carcinoma of the Head and Neck</title><source>Access via SAGE</source><source>MEDLINE</source><source>Access via Wiley Online Library</source><creator>Bice, Tristan C. ; Tran, Van ; Merkley, Mark A. ; Newlands, Shawn D. ; van der Sloot, Paul G. ; Wu, Shuang ; Miller, Matthew C.</creator><creatorcontrib>Bice, Tristan C. ; Tran, Van ; Merkley, Mark A. ; Newlands, Shawn D. ; van der Sloot, Paul G. ; Wu, Shuang ; Miller, Matthew C.</creatorcontrib><description>Objectives
(1) Determine factors influencing survival in patients diagnosed with spindle cell carcinoma (SpCC), a rare variant of head and neck squamous cell carcinoma (SCC). (2) Compare survival of patients with SpCC to those with conventional SCC.
Study Design
Retrospective cohort study.
Setting
Surveillance, Epidemiology, and End Results 18 database (years 2004-2009).
Subjects and Methods
Among patients receiving treatment for a single primary in the oral cavity, oropharynx, hypopharynx, or larynx, 118 subjects with SpCC and 18,298 subjects with SCC were identified with complete data for the variables of age, sex, grade, tumor size, stage group, and TNM stage. Disease-specific survival curves were compared. Univariate and multivariate analyses were used to examine the effects of each factor on survival over all sites and within each of 3 sites.
Results
Univariate analysis of the combination of the 3 anatomic subsites showed survival with SpCC was worse than with conventional SCC (P < .001). Three-year disease-specific survival with SpCC was 49.5%, and 5-year disease-specific survival was 40.2%. Compared with conventional SCC, survival was worse for SpCC of the oral cavity (P < .001) and oropharynx (P < .001) but no different for the larynx and hypopharynx site (P = .15). Multivariate analysis identified age (P = .02), tumor size (P = .006), and M stage (P < .001) as the only variables significantly affecting survival with SpCC. All variables significantly affected survival with conventional SCC.
Conclusions
Spindle cell carcinoma carries a worse prognosis than SCC. Larger tumor size, older age, and metastatic disease portend worse survival with SpCC of the head and neck.</description><identifier>ISSN: 0194-5998</identifier><identifier>EISSN: 1097-6817</identifier><identifier>DOI: 10.1177/0194599815594360</identifier><identifier>PMID: 26203085</identifier><language>eng</language><publisher>Los Angeles, CA: SAGE Publications</publisher><subject>Analysis of Variance ; Carcinoma - mortality ; Carcinoma, Squamous Cell - mortality ; Cohort Studies ; Female ; Head and Neck Neoplasms - mortality ; Humans ; Hypopharyngeal Neoplasms - mortality ; Laryngeal Neoplasms - mortality ; Male ; Middle Aged ; Mouth Neoplasms - mortality ; Multivariate Analysis ; Oropharyngeal Neoplasms - mortality ; Prognosis ; Retrospective Studies ; SEER ; spindle cell carcinoma ; squamous cell carcinoma ; survival</subject><ispartof>Otolaryngology-head and neck surgery, 2015-12, Vol.153 (6), p.973-980</ispartof><rights>American Academy of Otolaryngology—Head and Neck Surgery Foundation 2015</rights><rights>2015 American Association of Otolaryngology‐Head and Neck Surgery Foundation (AAO‐HNSF)</rights><rights>American Academy of Otolaryngology—Head and Neck Surgery Foundation 2015.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3866-5a9f5c1458f24b4e3fc0682f5808f3574055f24cd67eab1781245965c3feba373</citedby><cites>FETCH-LOGICAL-c3866-5a9f5c1458f24b4e3fc0682f5808f3574055f24cd67eab1781245965c3feba373</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://journals.sagepub.com/doi/pdf/10.1177/0194599815594360$$EPDF$$P50$$Gsage$$H</linktopdf><linktohtml>$$Uhttps://journals.sagepub.com/doi/10.1177/0194599815594360$$EHTML$$P50$$Gsage$$H</linktohtml><link.rule.ids>314,780,784,1417,21819,27924,27925,43621,43622,45574,45575</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26203085$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Bice, Tristan C.</creatorcontrib><creatorcontrib>Tran, Van</creatorcontrib><creatorcontrib>Merkley, Mark A.</creatorcontrib><creatorcontrib>Newlands, Shawn D.</creatorcontrib><creatorcontrib>van der Sloot, Paul G.</creatorcontrib><creatorcontrib>Wu, Shuang</creatorcontrib><creatorcontrib>Miller, Matthew C.</creatorcontrib><title>Disease-Specific Survival with Spindle Cell Carcinoma of the Head and Neck</title><title>Otolaryngology-head and neck surgery</title><addtitle>Otolaryngol Head Neck Surg</addtitle><description>Objectives
(1) Determine factors influencing survival in patients diagnosed with spindle cell carcinoma (SpCC), a rare variant of head and neck squamous cell carcinoma (SCC). (2) Compare survival of patients with SpCC to those with conventional SCC.
Study Design
Retrospective cohort study.
Setting
Surveillance, Epidemiology, and End Results 18 database (years 2004-2009).
Subjects and Methods
Among patients receiving treatment for a single primary in the oral cavity, oropharynx, hypopharynx, or larynx, 118 subjects with SpCC and 18,298 subjects with SCC were identified with complete data for the variables of age, sex, grade, tumor size, stage group, and TNM stage. Disease-specific survival curves were compared. Univariate and multivariate analyses were used to examine the effects of each factor on survival over all sites and within each of 3 sites.
Results
Univariate analysis of the combination of the 3 anatomic subsites showed survival with SpCC was worse than with conventional SCC (P < .001). Three-year disease-specific survival with SpCC was 49.5%, and 5-year disease-specific survival was 40.2%. Compared with conventional SCC, survival was worse for SpCC of the oral cavity (P < .001) and oropharynx (P < .001) but no different for the larynx and hypopharynx site (P = .15). Multivariate analysis identified age (P = .02), tumor size (P = .006), and M stage (P < .001) as the only variables significantly affecting survival with SpCC. All variables significantly affected survival with conventional SCC.
Conclusions
Spindle cell carcinoma carries a worse prognosis than SCC. Larger tumor size, older age, and metastatic disease portend worse survival with SpCC of the head and neck.</description><subject>Analysis of Variance</subject><subject>Carcinoma - mortality</subject><subject>Carcinoma, Squamous Cell - mortality</subject><subject>Cohort Studies</subject><subject>Female</subject><subject>Head and Neck Neoplasms - mortality</subject><subject>Humans</subject><subject>Hypopharyngeal Neoplasms - mortality</subject><subject>Laryngeal Neoplasms - mortality</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Mouth Neoplasms - mortality</subject><subject>Multivariate Analysis</subject><subject>Oropharyngeal Neoplasms - mortality</subject><subject>Prognosis</subject><subject>Retrospective Studies</subject><subject>SEER</subject><subject>spindle cell carcinoma</subject><subject>squamous cell carcinoma</subject><subject>survival</subject><issn>0194-5998</issn><issn>1097-6817</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkL1PwzAUxC0EoqWwMyGPLAE7jj8yQqEUVLVDYY4c55m65KPETav-96RKYUBCTG-4-53uHUKXlNxQKuUtoXHE41hRzuOICXKE-pTEMhCKymPU38vBXu-hM--XhBAhpDxFvVCEhBHF--jlwXnQHoL5CoyzzuB5U2_cRud469YLPF-5MssBDyHP8VDXxpVVoXFl8XoBeAw6w7rM8BTMxzk6sTr3cHG4A_Q2enwdjoPJ7Ol5eDcJDFNCBFzHlhsacWXDKI2AWUOECi1XRFnGZUQ4bxWTCQk6pVLRsP1RcMMspJpJNkDXXe6qrj4b8OukcN60_XQJVeMTKplSNGIRa62ks5q68r4Gm6xqV-h6l1CS7BdMfi_YIleH9CYtIPsBvidrDaozbF0Ou38Dk9l4ej8iklPRokGHev0OybJq6rId6u8uX9nGhf8</recordid><startdate>201512</startdate><enddate>201512</enddate><creator>Bice, Tristan C.</creator><creator>Tran, Van</creator><creator>Merkley, Mark A.</creator><creator>Newlands, Shawn D.</creator><creator>van der Sloot, Paul G.</creator><creator>Wu, Shuang</creator><creator>Miller, Matthew C.</creator><general>SAGE Publications</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>201512</creationdate><title>Disease-Specific Survival with Spindle Cell Carcinoma of the Head and Neck</title><author>Bice, Tristan C. ; Tran, Van ; Merkley, Mark A. ; Newlands, Shawn D. ; van der Sloot, Paul G. ; Wu, Shuang ; Miller, Matthew C.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3866-5a9f5c1458f24b4e3fc0682f5808f3574055f24cd67eab1781245965c3feba373</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Analysis of Variance</topic><topic>Carcinoma - mortality</topic><topic>Carcinoma, Squamous Cell - mortality</topic><topic>Cohort Studies</topic><topic>Female</topic><topic>Head and Neck Neoplasms - mortality</topic><topic>Humans</topic><topic>Hypopharyngeal Neoplasms - mortality</topic><topic>Laryngeal Neoplasms - mortality</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Mouth Neoplasms - mortality</topic><topic>Multivariate Analysis</topic><topic>Oropharyngeal Neoplasms - mortality</topic><topic>Prognosis</topic><topic>Retrospective Studies</topic><topic>SEER</topic><topic>spindle cell carcinoma</topic><topic>squamous cell carcinoma</topic><topic>survival</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Bice, Tristan C.</creatorcontrib><creatorcontrib>Tran, Van</creatorcontrib><creatorcontrib>Merkley, Mark A.</creatorcontrib><creatorcontrib>Newlands, Shawn D.</creatorcontrib><creatorcontrib>van der Sloot, Paul G.</creatorcontrib><creatorcontrib>Wu, Shuang</creatorcontrib><creatorcontrib>Miller, Matthew C.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Otolaryngology-head and neck surgery</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Bice, Tristan C.</au><au>Tran, Van</au><au>Merkley, Mark A.</au><au>Newlands, Shawn D.</au><au>van der Sloot, Paul G.</au><au>Wu, Shuang</au><au>Miller, Matthew C.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Disease-Specific Survival with Spindle Cell Carcinoma of the Head and Neck</atitle><jtitle>Otolaryngology-head and neck surgery</jtitle><addtitle>Otolaryngol Head Neck Surg</addtitle><date>2015-12</date><risdate>2015</risdate><volume>153</volume><issue>6</issue><spage>973</spage><epage>980</epage><pages>973-980</pages><issn>0194-5998</issn><eissn>1097-6817</eissn><abstract>Objectives
(1) Determine factors influencing survival in patients diagnosed with spindle cell carcinoma (SpCC), a rare variant of head and neck squamous cell carcinoma (SCC). (2) Compare survival of patients with SpCC to those with conventional SCC.
Study Design
Retrospective cohort study.
Setting
Surveillance, Epidemiology, and End Results 18 database (years 2004-2009).
Subjects and Methods
Among patients receiving treatment for a single primary in the oral cavity, oropharynx, hypopharynx, or larynx, 118 subjects with SpCC and 18,298 subjects with SCC were identified with complete data for the variables of age, sex, grade, tumor size, stage group, and TNM stage. Disease-specific survival curves were compared. Univariate and multivariate analyses were used to examine the effects of each factor on survival over all sites and within each of 3 sites.
Results
Univariate analysis of the combination of the 3 anatomic subsites showed survival with SpCC was worse than with conventional SCC (P < .001). Three-year disease-specific survival with SpCC was 49.5%, and 5-year disease-specific survival was 40.2%. Compared with conventional SCC, survival was worse for SpCC of the oral cavity (P < .001) and oropharynx (P < .001) but no different for the larynx and hypopharynx site (P = .15). Multivariate analysis identified age (P = .02), tumor size (P = .006), and M stage (P < .001) as the only variables significantly affecting survival with SpCC. All variables significantly affected survival with conventional SCC.
Conclusions
Spindle cell carcinoma carries a worse prognosis than SCC. Larger tumor size, older age, and metastatic disease portend worse survival with SpCC of the head and neck.</abstract><cop>Los Angeles, CA</cop><pub>SAGE Publications</pub><pmid>26203085</pmid><doi>10.1177/0194599815594360</doi><tpages>8</tpages></addata></record> |
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| ispartof | Otolaryngology-head and neck surgery, 2015-12, Vol.153 (6), p.973-980 |
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| language | eng |
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| source | Access via SAGE; MEDLINE; Access via Wiley Online Library |
| subjects | Analysis of Variance Carcinoma - mortality Carcinoma, Squamous Cell - mortality Cohort Studies Female Head and Neck Neoplasms - mortality Humans Hypopharyngeal Neoplasms - mortality Laryngeal Neoplasms - mortality Male Middle Aged Mouth Neoplasms - mortality Multivariate Analysis Oropharyngeal Neoplasms - mortality Prognosis Retrospective Studies SEER spindle cell carcinoma squamous cell carcinoma survival |
| title | Disease-Specific Survival with Spindle Cell Carcinoma of the Head and Neck |
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