Mutations of C-RAF are rare in human cancer because C-RAF has a low basal kinase activity compared with B-RAF

The protein kinase B-RAF is mutated in approximately 8% of human cancers. Here we show that presumptive mutants of the closely related kinase, C-RAF, were detected in only 4 of 545 (0.7%) cancer cell lines. The activity of two of the mutated proteins is not significantly different from that of wild-...

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Veröffentlicht in:	Cancer research (Chicago, Ill.) Ill.), 2005-11, Vol.65 (21), p.9719-9726
Hauptverfasser:	EMUSS, Victoria, GARNETT, Mathew, MASON, Clive, MARAIS, Richard
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenocarcinoma - enzymology Adenocarcinoma - genetics Amino Acid Sequence Animals Biological and medical sciences Carcinoma - enzymology Carcinoma - genetics Cell physiology Cell transformation and carcinogenesis. Action of oncogenes and antioncogenes Cercopithecus aethiops Colorectal Neoplasms - enzymology Colorectal Neoplasms - genetics COS Cells Enzyme Activation Fibrosarcoma - enzymology Fibrosarcoma - genetics Fundamental and applied biological sciences. Psychology Humans Lung Neoplasms - enzymology Lung Neoplasms - genetics Mice Molecular and cellular biology Molecular Sequence Data Mutagenesis, Site-Directed Neoplasms - enzymology Neoplasms - genetics NIH 3T3 Cells Proto-Oncogene Proteins B-raf - genetics Proto-Oncogene Proteins B-raf - metabolism Proto-Oncogene Proteins c-raf - genetics Proto-Oncogene Proteins c-raf - metabolism
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