Effect of Na super(+)/Ca super(2+) exchange inhibitor, KB-R7943 on ouabain-induced arrhythmias in guinea-pigs

We investigated protective effects of KB-R7943, a Na super(+)/Ca super(2+) exchange (NCX) inhibitor, on ouabain-induced tonotropy and arrhythmias in isolated whole atria and ouabain-induced changes in electrocardiogram (ECG) in the guinea-pig. KB-R7943 (10 and 30 mu M) suppressed the tonotropic effe...

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Veröffentlicht in:	British journal of pharmacology 1999-08, Vol.127 (8), p.1846-1850
Hauptverfasser:	Watano, Tomokazu, Harada, Yoshimitsu, Harada, Kengo, Nishimura, Noriyasu
Format:	Artikel
Sprache:	eng
Schlagworte:	ouabain
Online-Zugang:	Volltext
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