Multiple γc-dependent cytokines regulate T-cell development

Mutations in the common γ chain (γc) of cytokine receptors account for human X-linked severe combined immunodeficiency disease. γc contributes to ligand binding and signaling as a component of five cytokine receptors: interleukin-2-receptor (IL-2R), IL-4R, IL-7R, IL-9R and IL-15R. Here, Thomas Malek...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Immunology today (Amsterdam. Regular ed.) 1999-02, Vol.20 (2), p.71-76
Hauptverfasser:	Malek, Thomas R., Porter, Brian O., He, You-Wen
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antibodies, Monoclonal - pharmacology Antibodies, Monoclonal - toxicity Cell Differentiation Cytokine gc chain Hematopoiesis - genetics Hematopoiesis - physiology Humans IL-7 interleukin 15 receptors interleukin 2 receptors interleukin 4 receptors Interleukin 7 interleukin 7 receptors interleukin 9 receptors Interleukins - physiology Mice Mice, Knockout Models, Immunological Receptors, Antigen, T-Cell, gamma-delta - analysis Receptors, Cytokine - deficiency Receptors, Cytokine - genetics Receptors, Cytokine - physiology Receptors, Interleukin - chemistry Receptors, Interleukin - genetics Receptors, Interleukin - physiology Severe Combined Immunodeficiency - genetics Severe Combined Immunodeficiency - immunology Severe Combined Immunodeficiency - pathology T-cell development T-Lymphocyte Subsets - immunology T-Lymphocyte Subsets - pathology Thymus Gland - pathology X Chromosome - genetics X-linked severe combined immunodeficiency X-SCID
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	Mutations in the common γ chain (γc) of cytokine receptors account for human X-linked severe combined immunodeficiency disease. γc contributes to ligand binding and signaling as a component of five cytokine receptors: interleukin-2-receptor (IL-2R), IL-4R, IL-7R, IL-9R and IL-15R. Here, Thomas Malek and colleagues discuss the contribution of individual γc-dependent cytokines in both conventional and intraepithelial T-cell development.
ISSN:	0167-5699
DOI:	10.1016/S0167-5699(98)01391-7