Overexpression of GRß in colonic mucosal cell line partly reflects altered gene expression in colonic mucosa of patients with inflammatory bowel disease

•GRß overexpression rendered Caco-2 cells steroid insensitive.•GRß was located in the nucleus and had an GRα independent transcriptional activity.•GRß regulated the expression of numerous involved in intact barrier function. The glucocorticoid receptor (GR) plays a crucial role in inflammatory respo...

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Veröffentlicht in:	The Journal of steroid biochemistry and molecular biology 2016-01, Vol.155 (Pt A), p.76-84
Hauptverfasser:	Nagy, Zsolt, Acs, Bence, Butz, Henriett, Feldman, Karolina, Marta, Alexa, Szabo, Peter M., Baghy, Kornelia, Pazmany, Tamas, Racz, Karoly, Liko, Istvan, Patocs, Attila
Format:	Artikel
Sprache:	eng
Schlagworte:	Caco-2 Cells - drug effects Cell Adhesion - genetics Cell Movement - genetics Cell Nucleus - metabolism Cell Proliferation - genetics Colon - metabolism Colon - physiopathology Dexamethasone - pharmacology Gene expression Gene Expression Regulation - drug effects Glucocorticoid receptor beta Glucocorticoid resistance Humans Inflammation Inflammatory bowel disease Inflammatory Bowel Diseases - genetics Inflammatory Bowel Diseases - physiopathology Intestinal Mucosa - metabolism Intestinal Mucosa - physiopathology Receptors, Glucocorticoid - genetics Receptors, Glucocorticoid - metabolism Transcriptome
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