HO-1 inhibits IL-13-induced goblet cell hyperplasia associated with CLCA1 suppression in normal human bronchial epithelial cells

Mucus hypersecretion and goblet cell hyperplasia are common features that characterize asthma. IL-13 increases mucin (MUC) 5AC, the major component of airway mucus, in airway epithelial cells. According to the literature, IL-13 receptor activation leads to STAT6 activation and consequent induction o...

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Veröffentlicht in:	International immunopharmacology 2015-12, Vol.29 (2), p.448-453
Hauptverfasser:	Mishina, Kei, Shinkai, Masaharu, Shimokawaji, Tadasuke, Nagashima, Akimichi, Hashimoto, Yusuke, Inoue, Yoriko, Inayama, Yoshiaki, Rubin, Bruce K., Ishigatsubo, Yoshiaki, Kaneko, Takeshi
Format:	Artikel
Sprache:	eng
Schlagworte:	Bronchi - cytology Bronchi - drug effects Cells, Cultured Chloride Channels - antagonists & inhibitors Chloride Channels - biosynthesis Enzyme Inhibitors - pharmacology Epithelial Cells - drug effects Goblet Cells - drug effects Heme Oxygenase-1 - antagonists & inhibitors Heme Oxygenase-1 - pharmacology Hemin - metabolism Humans Hyperplasia - chemically induced Hyperplasia - prevention & control Interleukin-13 - antagonists & inhibitors Interleukin-13 - pharmacology Metalloporphyrins - pharmacology Mucin 5AC - biosynthesis Protoporphyrins - pharmacology Respiratory Mucosa - cytology Respiratory Mucosa - drug effects STAT6 Transcription Factor - antagonists & inhibitors STAT6 Transcription Factor - biosynthesis
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