Protective effects of melatonin on lipopolysaccharide-induced mastitis in mice

Melatonin, a secretory product of the pineal gland, has been reported to have antioxidant and anti-inflammatory effects. However, the protective effects of melatonin on lipopolysaccharide (LPS)-induced mastitis have not been reported. The purpose of this study was to investigate the anti-inflammator...

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Veröffentlicht in:	International immunopharmacology 2015-12, Vol.29 (2), p.263-268
Hauptverfasser:	Shao, Guoxi, Tian, Yinggang, Wang, Haiyu, Liu, Fangning, Xie, Guanghong
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Anti-Inflammatory Agents - therapeutic use Antioxidants - therapeutic use Cytokines - metabolism Female Lipopolysaccharides - antagonists & inhibitors Lipopolysaccharides - toxicity LPS Mammary Glands, Animal - pathology Mastitis Mastitis - chemically induced Mastitis - prevention & control Melatonin Melatonin - therapeutic use Mice NF-kappa B - drug effects NF-κB Peroxidase - metabolism PPAR gamma - biosynthesis PPAR gamma - genetics PPAR-γ Tetrazolium Salts Thiazoles Toll-Like Receptor 4 - biosynthesis Toll-Like Receptor 4 - genetics
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