Phosphatase regulation of macrophage activation

Phosphatase regulation of macrophage activation

Highlights • The lipid phosphatases SHIP and PTEN negatively regulate M(IL-4) activation. • The protein tyrosine phosphatase (PTP) SHP-2 negatively regulates M(IL-4) activation. • The PTP PTPN22 and the protein phosphatase MKP-1 negatively regulate M(IFNγ) activation. • The PTPs PTP1B and SHP-1 nega...

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Veröffentlicht in:Seminars in immunology 2015-08, Vol.27 (4), p.276-285
Hauptverfasser: Kozicky, Lisa K, Sly, Laura M
Format: Artikel
Sprache:eng
Schlagworte:
Allergy and Immunology
Animals
Humans
Lipid phosphatase
Macrophage Activation
Macrophages - cytology
Macrophages - enzymology
Macrophages - immunology
MKP-1
Phosphoric Monoester Hydrolases - metabolism
Protein phosphatase
Protein tyrosine phosphatase
Protein Tyrosine Phosphatases - metabolism
PTEN
PTP1B
PTPN22
SHIP
SHP-1
Shp2
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Beschreibung
Zusammenfassung:Highlights • The lipid phosphatases SHIP and PTEN negatively regulate M(IL-4) activation. • The protein tyrosine phosphatase (PTP) SHP-2 negatively regulates M(IL-4) activation. • The PTP PTPN22 and the protein phosphatase MKP-1 negatively regulate M(IFNγ) activation. • The PTPs PTP1B and SHP-1 negatively regulate M(LPS) activation.
ISSN:1044-5323
1096-3618
DOI:10.1016/j.smim.2015.07.001