A Randomized Trial of Intensive Lipid-Lowering Therapy in Calcific Aortic Stenosis

Calcific aortic stenosis, a relatively common problem in the elderly, has been found to be associated with atherosclerosis and hypercholesterolemia. This study found that, contrary to expectations, intensive lipid-lowering therapy with atorvastatin, which reduced low-density lipoprotein cholesterol...

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Veröffentlicht in:	The New England journal of medicine 2005-06, Vol.352 (23), p.2389-2397
Hauptverfasser:	Cowell, S. Joanna, Newby, David E, Prescott, Robin J, Bloomfield, Peter, Reid, John, Northridge, David B, Boon, Nicholas A
Format:	Artikel
Sprache:	eng
Schlagworte:	Age Anticholesteremic Agents - administration & dosage Anticholesteremic Agents - adverse effects Anticholesteremic Agents - therapeutic use Aortic Valve - diagnostic imaging Aortic Valve Stenosis - diagnostic imaging Aortic Valve Stenosis - drug therapy Atorvastatin Calcium Blood Flow Velocity Calcinosis - drug therapy Cardiology Cardiovascular disease Cholesterol, LDL - blood Coronary vessels Disease Progression Double-Blind Method Echocardiography, Doppler Heptanoic Acids - administration & dosage Heptanoic Acids - adverse effects Heptanoic Acids - therapeutic use Humans Hydroxymethylglutaryl-CoA Reductase Inhibitors - administration & dosage Hydroxymethylglutaryl-CoA Reductase Inhibitors - adverse effects Hydroxymethylglutaryl-CoA Reductase Inhibitors - therapeutic use Lipids Pyrroles - administration & dosage Pyrroles - adverse effects Pyrroles - therapeutic use Statins Treatment Failure
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