Functional expression of human and Arabidopsis protein phosphatase 2A in Saccharomyces cerevisiae and isolation of dominant-defective mutants

Protein phosphatase 2A (PP2A), a heterotrimeric serine/threonine-specific protein phosphatase, comprises a catalytic subunit and two distinct regulatory subunits, A and B. The primary sequence of the catalytic (C) subunit is highly conserved in evolution, and its function has been shown to be essent...

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Veröffentlicht in:	Gene 1999-06, Vol.234 (1), p.35-44
Hauptverfasser:	Lizotte, D.L., McManus, D.D., Cohen, H.R., DeLong, A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Alleles Amino Acid Sequence Animals Arabidopsis Arabidopsis - enzymology Arabidopsis thaliana Base Sequence Catalytic Domain Catalytic subunit Cloning, Molecular DNA Primers dominance dominant defective alleles Dominant-negative Functional complementation gene expression gene transfer Genes, Dominant genetic complementation Genetic Complementation Test genetic transformation Humans Mice Molecular Sequence Data mutagenesis Mutagenesis, Site-Directed mutants Mutational analysis phosphoprotein phosphatase phosphoprotein phosphatase 2A Phosphoprotein Phosphatases - chemistry Phosphoprotein Phosphatases - genetics Phosphoprotein Phosphatases - isolation & purification Protein Phosphatase 2 Saccharomyces cerevisiae Saccharomyces cerevisiae - genetics Sequence Homology, Amino Acid site-directed mutagenesis
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