Aurora-A/STK15 T+91A is a general low penetrance cancer susceptibility gene: a meta-analysis of multiple cancer types

STK15 (Aurora-A) is a serine/threonine kinase involved in mitotic chromosomal segregation. A genetic variant in STK15 T+91A (resulting in the amino acid substitution F31I) is associated with increased aneuploidy in colon tumors and cell transformation in vitro. Since this polymorphism plays a role i...

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Veröffentlicht in:	Carcinogenesis (New York) 2005-08, Vol.26 (8), p.1368-1373
Hauptverfasser:	Ewart-Toland, Amanda, Dai, Qi, Gao, Yu-Tang, Nagase, Hiroki, Dunlop, Malcolm G., Farrington, Susan M., Barnetson, Rebecca A., Anton-Culver, Hoda, Peel, David, Ziogas, Argyrios, Lin, Dongxin, Miao, Xiaoping, Sun, Tong, Ostrander, Elaine A., Stanford, Janet L., Langlois, Mariela, Chan, June M., Yuan, Jinwei, Harris, Curtis C., Bowman, Elise D., Clayman, Gary L., Lippman, Scott M., Lee, J. Jack, Zheng, Wei, Balmain, Allan
Format:	Artikel
Sprache:	eng
Schlagworte:	a low penetrance cancer susceptibility allele variant Animals Aurora Kinase A Aurora Kinases Biological and medical sciences Breast Neoplasms - genetics CAMS Carcinogenesis, carcinogens and anticarcinogens Case-Control Studies Chinese Academy of Medical Sciences Colonic Neoplasms - genetics Epidemiology and End Results Cancer Registry Esophageal Neoplasms - genetics Female Genetic Predisposition to Disease - genetics Genetic Variation Genotype Humans Lung Neoplasms - genetics M.D. Anderson Cancer Center Male MDA Medical sciences Mice PAR PHS Physician's Health Study population attributable risk Prostatic Neoplasms - genetics Protein Serine-Threonine Kinases - genetics Protein Serine-Threonine Kinases - metabolism SBCS Seattle-Puget Sound Surveillance Skin Neoplasms - genetics SPS SEER STK15T+91A The Shanghai Breast Cancer Study Tumors UCI University of California Irvine
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