Programmed death-1 ligand 1 and 2 are highly expressed in pleomorphic carcinomas of the lung: Comparison of sarcomatous and carcinomatous areas
Highlights • We evaluate the PD-1/PD-Ls pathway molecules in pulmonary pleomorphic carcinoma (PC). • PD-L1 and PD-L2 are highly expressed in pulmonary PCs. • PD-L1 expression is higher in sarcomatous areas than carcinomatous portion in PCs. • PD-L1-positive PCs were infiltrated by higher numbers of...
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| Veröffentlicht in: | European journal of cancer (1990) 2015-11, Vol.51 (17), p.2698-2707 |
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| container_issue | 17 |
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| container_title | European journal of cancer (1990) |
| container_volume | 51 |
| creator | Kim, Sehui Kim, Moon-Young Koh, Jaemoon Go, Heounjeong Lee, Dong Soo Jeon, Yoon Kyung Chung, Doo Hyun |
| description | Highlights • We evaluate the PD-1/PD-Ls pathway molecules in pulmonary pleomorphic carcinoma (PC). • PD-L1 and PD-L2 are highly expressed in pulmonary PCs. • PD-L1 expression is higher in sarcomatous areas than carcinomatous portion in PCs. • PD-L1-positive PCs were infiltrated by higher numbers of CD8+ lymphocytes. • Targeting the PD-1/PD-Ls pathway may be potential therapeutic strategy for pulmonary PC. |
| doi_str_mv | 10.1016/j.ejca.2015.08.013 |
| format | Article |
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All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c547t-b0522ee83d31a0f20e9829bbf989488791a4a88aae4cefcea3d80aec3bac118a3</citedby><cites>FETCH-LOGICAL-c547t-b0522ee83d31a0f20e9829bbf989488791a4a88aae4cefcea3d80aec3bac118a3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.ejca.2015.08.013$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>315,781,785,3551,27929,27930,46000</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26329973$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kim, Sehui</creatorcontrib><creatorcontrib>Kim, Moon-Young</creatorcontrib><creatorcontrib>Koh, Jaemoon</creatorcontrib><creatorcontrib>Go, Heounjeong</creatorcontrib><creatorcontrib>Lee, Dong Soo</creatorcontrib><creatorcontrib>Jeon, Yoon Kyung</creatorcontrib><creatorcontrib>Chung, Doo Hyun</creatorcontrib><title>Programmed death-1 ligand 1 and 2 are highly expressed in pleomorphic carcinomas of the lung: Comparison of sarcomatous and carcinomatous areas</title><title>European journal of cancer (1990)</title><addtitle>Eur J Cancer</addtitle><description>Highlights • We evaluate the PD-1/PD-Ls pathway molecules in pulmonary pleomorphic carcinoma (PC). • PD-L1 and PD-L2 are highly expressed in pulmonary PCs. • PD-L1 expression is higher in sarcomatous areas than carcinomatous portion in PCs. • PD-L1-positive PCs were infiltrated by higher numbers of CD8+ lymphocytes. • Targeting the PD-1/PD-Ls pathway may be potential therapeutic strategy for pulmonary PC.</description><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>B7-H1 Antigen - biosynthesis</subject><subject>Cancer immunotherapy</subject><subject>Carcinoma, Non-Small-Cell Lung - metabolism</subject><subject>Carcinoma, Non-Small-Cell Lung - pathology</subject><subject>CD8-Positive T-Lymphocytes - metabolism</subject><subject>Disease-Free Survival</subject><subject>Female</subject><subject>Hematology, Oncology and Palliative Medicine</subject><subject>Humans</subject><subject>Immunohistochemistry</subject><subject>Kaplan-Meier Estimate</subject><subject>Lung Neoplasms - metabolism</subject><subject>Lung Neoplasms - pathology</subject><subject>Lymphocytes, Tumor-Infiltrating - metabolism</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Pleomorphic carcinoma of the lung</subject><subject>Prognosis</subject><subject>Programmed Cell Death 1 Ligand 2 Protein - biosynthesis</subject><subject>Programmed Cell Death 1 Receptor - metabolism</subject><subject>Programmed death-1</subject><subject>Programmed death-1 ligand 1</subject><subject>Sarcoma - metabolism</subject><subject>Sarcoma - pathology</subject><subject>Sarcomatoid carcinoma of the lung</subject><subject>Signal Transduction</subject><subject>Tissue Array Analysis</subject><issn>0959-8049</issn><issn>1879-0852</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kk-L1TAUxYsoznP0C7iQLN203iTtNBERhof_YEBBXYfb9PY1z7apSSu-T-FXNvWNs3DhJoHL7xySc26WPeVQcOBXL44FHS0WAnhVgCqAy3vZjqta56AqcT_bga50rqDUF9mjGI8AUKsSHmYX4koKrWu5y359Cv4QcBypZS3h0uecDe6AU8s4207BMBDr3aEfTox-zoFiTKyb2DyQH32Ye2eZxWDd5EeMzHds6YkN63R4yfZ-nDG46KdtHhOVmMWv8Y_3neo8CYTxcfagwyHSk9v7Mvv69s2X_fv85uO7D_vrm9xWZb3kDVRCECnZSo7QCSCthG6aTitdqhQBxxKVQqTSUmcJZasAycoGLecK5WX2_Ow7B_99pbiY0UVLw4ATpccYXsu6rFVKM6HijNrgYwzUmTm4EcPJcDBbEeZotiLMVoQBZVIRSfTs1n9tUrZ3kr_JJ-DVGaD0yx-OgonW0WSpdYHsYlrv_u__-h-5HdzkLA7f6ETx6NcwpfwMN1EYMJ-3Vdg2gVcACmQlfwOV_rD_</recordid><startdate>20151101</startdate><enddate>20151101</enddate><creator>Kim, Sehui</creator><creator>Kim, Moon-Young</creator><creator>Koh, Jaemoon</creator><creator>Go, Heounjeong</creator><creator>Lee, Dong Soo</creator><creator>Jeon, Yoon Kyung</creator><creator>Chung, Doo Hyun</creator><general>Elsevier Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20151101</creationdate><title>Programmed death-1 ligand 1 and 2 are highly expressed in pleomorphic carcinomas of the lung: Comparison of sarcomatous and carcinomatous areas</title><author>Kim, Sehui ; Kim, Moon-Young ; Koh, Jaemoon ; Go, Heounjeong ; Lee, Dong Soo ; Jeon, Yoon Kyung ; Chung, Doo Hyun</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c547t-b0522ee83d31a0f20e9829bbf989488791a4a88aae4cefcea3d80aec3bac118a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>B7-H1 Antigen - biosynthesis</topic><topic>Cancer immunotherapy</topic><topic>Carcinoma, Non-Small-Cell Lung - metabolism</topic><topic>Carcinoma, Non-Small-Cell Lung - pathology</topic><topic>CD8-Positive T-Lymphocytes - metabolism</topic><topic>Disease-Free Survival</topic><topic>Female</topic><topic>Hematology, Oncology and Palliative Medicine</topic><topic>Humans</topic><topic>Immunohistochemistry</topic><topic>Kaplan-Meier Estimate</topic><topic>Lung Neoplasms - metabolism</topic><topic>Lung Neoplasms - pathology</topic><topic>Lymphocytes, Tumor-Infiltrating - metabolism</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Pleomorphic carcinoma of the lung</topic><topic>Prognosis</topic><topic>Programmed Cell Death 1 Ligand 2 Protein - biosynthesis</topic><topic>Programmed Cell Death 1 Receptor - metabolism</topic><topic>Programmed death-1</topic><topic>Programmed death-1 ligand 1</topic><topic>Sarcoma - metabolism</topic><topic>Sarcoma - pathology</topic><topic>Sarcomatoid carcinoma of the lung</topic><topic>Signal Transduction</topic><topic>Tissue Array Analysis</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kim, Sehui</creatorcontrib><creatorcontrib>Kim, Moon-Young</creatorcontrib><creatorcontrib>Koh, Jaemoon</creatorcontrib><creatorcontrib>Go, Heounjeong</creatorcontrib><creatorcontrib>Lee, Dong Soo</creatorcontrib><creatorcontrib>Jeon, Yoon Kyung</creatorcontrib><creatorcontrib>Chung, Doo Hyun</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>European journal of cancer (1990)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kim, Sehui</au><au>Kim, Moon-Young</au><au>Koh, Jaemoon</au><au>Go, Heounjeong</au><au>Lee, Dong Soo</au><au>Jeon, Yoon Kyung</au><au>Chung, Doo Hyun</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Programmed death-1 ligand 1 and 2 are highly expressed in pleomorphic carcinomas of the lung: Comparison of sarcomatous and carcinomatous areas</atitle><jtitle>European journal of cancer (1990)</jtitle><addtitle>Eur J Cancer</addtitle><date>2015-11-01</date><risdate>2015</risdate><volume>51</volume><issue>17</issue><spage>2698</spage><epage>2707</epage><pages>2698-2707</pages><issn>0959-8049</issn><eissn>1879-0852</eissn><abstract>Highlights • We evaluate the PD-1/PD-Ls pathway molecules in pulmonary pleomorphic carcinoma (PC). • PD-L1 and PD-L2 are highly expressed in pulmonary PCs. • PD-L1 expression is higher in sarcomatous areas than carcinomatous portion in PCs. • PD-L1-positive PCs were infiltrated by higher numbers of CD8+ lymphocytes. • Targeting the PD-1/PD-Ls pathway may be potential therapeutic strategy for pulmonary PC.</abstract><cop>England</cop><pub>Elsevier Ltd</pub><pmid>26329973</pmid><doi>10.1016/j.ejca.2015.08.013</doi><tpages>10</tpages></addata></record> |
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| identifier | ISSN: 0959-8049 |
| ispartof | European journal of cancer (1990), 2015-11, Vol.51 (17), p.2698-2707 |
| issn | 0959-8049 1879-0852 |
| language | eng |
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| subjects | Aged Aged, 80 and over B7-H1 Antigen - biosynthesis Cancer immunotherapy Carcinoma, Non-Small-Cell Lung - metabolism Carcinoma, Non-Small-Cell Lung - pathology CD8-Positive T-Lymphocytes - metabolism Disease-Free Survival Female Hematology, Oncology and Palliative Medicine Humans Immunohistochemistry Kaplan-Meier Estimate Lung Neoplasms - metabolism Lung Neoplasms - pathology Lymphocytes, Tumor-Infiltrating - metabolism Male Middle Aged Pleomorphic carcinoma of the lung Prognosis Programmed Cell Death 1 Ligand 2 Protein - biosynthesis Programmed Cell Death 1 Receptor - metabolism Programmed death-1 Programmed death-1 ligand 1 Sarcoma - metabolism Sarcoma - pathology Sarcomatoid carcinoma of the lung Signal Transduction Tissue Array Analysis |
| title | Programmed death-1 ligand 1 and 2 are highly expressed in pleomorphic carcinomas of the lung: Comparison of sarcomatous and carcinomatous areas |
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