Interdependence of ATP signalling and pannexin channels; the servant was really the master all along?
Pannexin channels are recognized as important conduits for the release of ATP, which contributes to purinergic signalling. Pathologically, ATP release via these channels acts as a find-me signal for apoptotic cell clearance. Accordingly, there is considerable and growing interest in understanding th...
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Veröffentlicht in: | Biochemical journal 2015-12, Vol.472 (3), p.e27-e30 |
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description | Pannexin channels are recognized as important conduits for the release of ATP, which contributes to purinergic signalling. Pathologically, ATP release via these channels acts as a find-me signal for apoptotic cell clearance. Accordingly, there is considerable and growing interest in understanding the function and regulation of pannexin channels. In a recent issue of the Biochemical Journal, Boyce et al. provide evidence that the surface expression of pannexin channels is regulated by extracellular ATP. They propose a model in which ATP triggers pannexin channel internalization through a pathway involving clathrin- and caveolin-independent entry into early endosomes. Intriguingly, their evidence suggests that internalization is initiated through the association of ATP with pannexin channels themselves as well as ionotropic purinergic receptor 7 (P2X7) receptors. |
doi_str_mv | 10.1042/BJ20151016 |
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Pathologically, ATP release via these channels acts as a find-me signal for apoptotic cell clearance. Accordingly, there is considerable and growing interest in understanding the function and regulation of pannexin channels. In a recent issue of the Biochemical Journal, Boyce et al. provide evidence that the surface expression of pannexin channels is regulated by extracellular ATP. They propose a model in which ATP triggers pannexin channel internalization through a pathway involving clathrin- and caveolin-independent entry into early endosomes. 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Pathologically, ATP release via these channels acts as a find-me signal for apoptotic cell clearance. Accordingly, there is considerable and growing interest in understanding the function and regulation of pannexin channels. In a recent issue of the Biochemical Journal, Boyce et al. provide evidence that the surface expression of pannexin channels is regulated by extracellular ATP. They propose a model in which ATP triggers pannexin channel internalization through a pathway involving clathrin- and caveolin-independent entry into early endosomes. Intriguingly, their evidence suggests that internalization is initiated through the association of ATP with pannexin channels themselves as well as ionotropic purinergic receptor 7 (P2X7) receptors.</description><subject>Adenosine Triphosphate - metabolism</subject><subject>Animals</subject><subject>Connexins - metabolism</subject><subject>Humans</subject><subject>Models, Biological</subject><subject>Receptors, Purinergic P2X7 - metabolism</subject><subject>Signal Transduction - physiology</subject><issn>0264-6021</issn><issn>1470-8728</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpFkE1Lw0AQhhdRbK1e_AGyRxGiM5tkN8GD1OJHpaCHeg6b3UkbSTc1m6r996a26mGYeYeH5_AydopwiRCJq9snARgjoNxjfYwUBIkSyT7rg5BRIEFgjx15_waAEURwyHpCSgzTSPYZjV1LjaUlOUvOEK8LPpy-cF_OnK6q0s24dpYvtXP0VTpu5pur8te8nRP31Hxo1_JP7XlDHb_-eS-076S8y93UbnZzzA4KXXk62e0Be72_m44eg8nzw3g0nARGJKoNbEppkiMIlUTWFDKNTQwJWGtDaQBzKhA1FjZMcpsXwkqjdCoUyjhNTZjLcMDOt95lU7-vyLfZovSGqko7qlc-QxWqSEkJ2KEXW9Q0tfcNFdmyKRe6WWcI2abW7L_WDj7beVf5guwf-ttj-A1WlXJQ</recordid><startdate>20151215</startdate><enddate>20151215</enddate><creator>Jackson, Michael F</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20151215</creationdate><title>Interdependence of ATP signalling and pannexin channels; the servant was really the master all along?</title><author>Jackson, Michael F</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c287t-d9e98b102784dcf695c5080ddd36c01bef11a1fd38bdbf2d6c7a92716599c3b63</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Adenosine Triphosphate - metabolism</topic><topic>Animals</topic><topic>Connexins - metabolism</topic><topic>Humans</topic><topic>Models, Biological</topic><topic>Receptors, Purinergic P2X7 - metabolism</topic><topic>Signal Transduction - physiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Jackson, Michael F</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Biochemical journal</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Jackson, Michael F</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Interdependence of ATP signalling and pannexin channels; the servant was really the master all along?</atitle><jtitle>Biochemical journal</jtitle><addtitle>Biochem J</addtitle><date>2015-12-15</date><risdate>2015</risdate><volume>472</volume><issue>3</issue><spage>e27</spage><epage>e30</epage><pages>e27-e30</pages><issn>0264-6021</issn><eissn>1470-8728</eissn><abstract>Pannexin channels are recognized as important conduits for the release of ATP, which contributes to purinergic signalling. 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subjects | Adenosine Triphosphate - metabolism Animals Connexins - metabolism Humans Models, Biological Receptors, Purinergic P2X7 - metabolism Signal Transduction - physiology |
title | Interdependence of ATP signalling and pannexin channels; the servant was really the master all along? |
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