Plasma concentrations of molecular lipid species in relation to coronary plaque characteristics and cardiovascular outcome: Results of the ATHEROREMO-IVUS study
Abstract Background and Aims Previous lipidomics analyses have demonstrated that several lipid molecules in plasma are associated with fatal outcome in patients with coronary artery disease (CAD). This study aims to investigate the associations of previously identified high risk lipid molecules in p...
Gespeichert in:
| Veröffentlicht in: | Atherosclerosis 2015-12, Vol.243 (2), p.560-566 |
|---|---|
| Hauptverfasser: | , , , , , , , , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 566 |
|---|---|
| container_issue | 2 |
| container_start_page | 560 |
| container_title | Atherosclerosis |
| container_volume | 243 |
| creator | Cheng, Jin M Suoniemi, Matti Kardys, Isabella Vihervaara, Terhi de Boer, Sanneke P.M Akkerhuis, K. Martijn Sysi-Aho, Marko Ekroos, Kim Garcia-Garcia, Hector M Oemrawsingh, Rohit M Regar, Evelyn Koenig, Wolfgang Serruys, Patrick W van Geuns, Robert-Jan Boersma, Eric Laaksonen, Reijo |
| description | Abstract Background and Aims Previous lipidomics analyses have demonstrated that several lipid molecules in plasma are associated with fatal outcome in patients with coronary artery disease (CAD). This study aims to investigate the associations of previously identified high risk lipid molecules in plasma with coronary plaque characteristics derived from intravascular ultrasound virtual histology (IVUS-VH) imaging, with coronary lipid core burden index (LCBI) on near-infrared spectroscopy (NIRS), and with one year cardiovascular outcome in patients with CAD. Methods Between 2008 and 2011, IVUS-VH imaging of a non-culprit coronary artery was performed in 581 patients who underwent coronary angiography for acute coronary syndrome (ACS) or stable CAD. NIRS imaging was additionally performed in 191 patients. Plasma concentrations of molecular lipids were measured with mass spectrometry. Results Several cholesteryl ester, ceramide and lactosylceramide species and ceramide ratios were associated with vulnerable plaque characteristics on IVUS-VH and NIRS imaging and with 1-year major adverse cardiac events (MACE, defined as all-cause mortality, ACS and unplanned coronary revascularization). In particular, ceramide d18:1/16:0 was consistently associated with higher necrotic core fraction on IVUS-VH (p = 0.001), higher LCBI (p = 0.024) on NIRS and higher MACE rate (adjusted HR 1.79 per standard deviation increase in log-transformed lipid concentration, 95%CI 1.24–2.59, p = 0.002). Conclusion Several molecular lipid species, and particularly ceramide(d18:1/16:0), are associated with the fraction of necrotic core tissue and lipid core burden in coronary atherosclerosis, and are predictive for 1-year clinical outcome after coronary angiography. These molecular lipids may improve risk stratification in CAD and may also be interesting therapeutic targets for the treatment of atherosclerotic disease. |
| doi_str_mv | 10.1016/j.atherosclerosis.2015.10.022 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1737476530</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S0021915015301684</els_id><sourcerecordid>1737476530</sourcerecordid><originalsourceid>FETCH-LOGICAL-c510t-fb57e67ef635ea28bd60fc4510ad30e4347c71de39fb664c75b16cf0cac179d3</originalsourceid><addsrcrecordid>eNqNUk1vEzEUXCEQDYW_gHxB4rKpvV_OIoFUVaGtVBSUBq6W8_xWdfCug5-3Uv4NP7XepnDoiYt9eDPzNDMvyz4IPhdcNGe7uY53GDyBm15L84KLOs3mvCheZDOxkG0uqkX1MptxXoi8FTU_yd4Q7TjnlRSL19lJ0dRF2bbVLPvz3WnqNQM_AA4x6Gj9QMx3rPcOYXQ6MGf31jDaI1gkZgcW0D3iWPSJGPygw4Htnf49IoM7HTREDJaiBWJ6MAx0MNbfazrq-TGC7_ETWyONLj5uS57Y-eZquV6tl99W-fXPH7eM4mgOb7NXnXaE757-02zzdbm5uMpvVpfXF-c3OdSCx7zb1hIbiV1T1qiLxdY0vIMqzbQpOVZlJUEKg2XbbZumAllvRQMdBw1CtqY8zT4eZffBJxsUVW8J0Dk9oB9JCVnKSjZ1yRP08xEKKX8K2Kl9sH2KQAmupo7UTj3rSE0dTePUUeK_f1o1bns0_9h_S0mAyyMAk997i0FRSj71Y2xAiMp4-9-rvjxTAmcHC9r9wgPSzo9hSKEqoahQXN1OBzPdi0g-RbOoygcsTsWT</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1737476530</pqid></control><display><type>article</type><title>Plasma concentrations of molecular lipid species in relation to coronary plaque characteristics and cardiovascular outcome: Results of the ATHEROREMO-IVUS study</title><source>MEDLINE</source><source>Elsevier ScienceDirect Journals</source><creator>Cheng, Jin M ; Suoniemi, Matti ; Kardys, Isabella ; Vihervaara, Terhi ; de Boer, Sanneke P.M ; Akkerhuis, K. Martijn ; Sysi-Aho, Marko ; Ekroos, Kim ; Garcia-Garcia, Hector M ; Oemrawsingh, Rohit M ; Regar, Evelyn ; Koenig, Wolfgang ; Serruys, Patrick W ; van Geuns, Robert-Jan ; Boersma, Eric ; Laaksonen, Reijo</creator><creatorcontrib>Cheng, Jin M ; Suoniemi, Matti ; Kardys, Isabella ; Vihervaara, Terhi ; de Boer, Sanneke P.M ; Akkerhuis, K. Martijn ; Sysi-Aho, Marko ; Ekroos, Kim ; Garcia-Garcia, Hector M ; Oemrawsingh, Rohit M ; Regar, Evelyn ; Koenig, Wolfgang ; Serruys, Patrick W ; van Geuns, Robert-Jan ; Boersma, Eric ; Laaksonen, Reijo</creatorcontrib><description>Abstract Background and Aims Previous lipidomics analyses have demonstrated that several lipid molecules in plasma are associated with fatal outcome in patients with coronary artery disease (CAD). This study aims to investigate the associations of previously identified high risk lipid molecules in plasma with coronary plaque characteristics derived from intravascular ultrasound virtual histology (IVUS-VH) imaging, with coronary lipid core burden index (LCBI) on near-infrared spectroscopy (NIRS), and with one year cardiovascular outcome in patients with CAD. Methods Between 2008 and 2011, IVUS-VH imaging of a non-culprit coronary artery was performed in 581 patients who underwent coronary angiography for acute coronary syndrome (ACS) or stable CAD. NIRS imaging was additionally performed in 191 patients. Plasma concentrations of molecular lipids were measured with mass spectrometry. Results Several cholesteryl ester, ceramide and lactosylceramide species and ceramide ratios were associated with vulnerable plaque characteristics on IVUS-VH and NIRS imaging and with 1-year major adverse cardiac events (MACE, defined as all-cause mortality, ACS and unplanned coronary revascularization). In particular, ceramide d18:1/16:0 was consistently associated with higher necrotic core fraction on IVUS-VH (p = 0.001), higher LCBI (p = 0.024) on NIRS and higher MACE rate (adjusted HR 1.79 per standard deviation increase in log-transformed lipid concentration, 95%CI 1.24–2.59, p = 0.002). Conclusion Several molecular lipid species, and particularly ceramide(d18:1/16:0), are associated with the fraction of necrotic core tissue and lipid core burden in coronary atherosclerosis, and are predictive for 1-year clinical outcome after coronary angiography. These molecular lipids may improve risk stratification in CAD and may also be interesting therapeutic targets for the treatment of atherosclerotic disease.</description><identifier>ISSN: 0021-9150</identifier><identifier>EISSN: 1879-1484</identifier><identifier>DOI: 10.1016/j.atherosclerosis.2015.10.022</identifier><identifier>PMID: 26523994</identifier><language>eng</language><publisher>Ireland: Elsevier Ireland Ltd</publisher><subject>Acute Coronary Syndrome - blood ; Acute Coronary Syndrome - diagnostic imaging ; Acute Coronary Syndrome - mortality ; Acute Coronary Syndrome - therapy ; Aged ; Atherosclerosis ; Biomarkers - blood ; Cardiovascular ; Coronary Angiography ; Coronary Artery Disease - blood ; Coronary Artery Disease - diagnostic imaging ; Coronary Artery Disease - mortality ; Coronary Artery Disease - therapy ; Coronary Vessels - diagnostic imaging ; Coronary Vessels - metabolism ; Disease Progression ; Female ; Humans ; Intravascular ultrasound ; Kaplan-Meier Estimate ; Lipids ; Lipids - blood ; Male ; Mass Spectrometry ; Middle Aged ; Myocardial Revascularization ; Near-infrared spectroscopy ; Necrosis ; Netherlands ; Plaque, Atherosclerotic ; Predictive Value of Tests ; Prognosis ; Proportional Hazards Models ; Risk Factors ; Rupture, Spontaneous ; Spectroscopy, Near-Infrared ; Ultrasonography, Interventional</subject><ispartof>Atherosclerosis, 2015-12, Vol.243 (2), p.560-566</ispartof><rights>Elsevier Ireland Ltd</rights><rights>2015 Elsevier Ireland Ltd</rights><rights>Copyright © 2015 Elsevier Ireland Ltd. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c510t-fb57e67ef635ea28bd60fc4510ad30e4347c71de39fb664c75b16cf0cac179d3</citedby><cites>FETCH-LOGICAL-c510t-fb57e67ef635ea28bd60fc4510ad30e4347c71de39fb664c75b16cf0cac179d3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0021915015301684$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26523994$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Cheng, Jin M</creatorcontrib><creatorcontrib>Suoniemi, Matti</creatorcontrib><creatorcontrib>Kardys, Isabella</creatorcontrib><creatorcontrib>Vihervaara, Terhi</creatorcontrib><creatorcontrib>de Boer, Sanneke P.M</creatorcontrib><creatorcontrib>Akkerhuis, K. Martijn</creatorcontrib><creatorcontrib>Sysi-Aho, Marko</creatorcontrib><creatorcontrib>Ekroos, Kim</creatorcontrib><creatorcontrib>Garcia-Garcia, Hector M</creatorcontrib><creatorcontrib>Oemrawsingh, Rohit M</creatorcontrib><creatorcontrib>Regar, Evelyn</creatorcontrib><creatorcontrib>Koenig, Wolfgang</creatorcontrib><creatorcontrib>Serruys, Patrick W</creatorcontrib><creatorcontrib>van Geuns, Robert-Jan</creatorcontrib><creatorcontrib>Boersma, Eric</creatorcontrib><creatorcontrib>Laaksonen, Reijo</creatorcontrib><title>Plasma concentrations of molecular lipid species in relation to coronary plaque characteristics and cardiovascular outcome: Results of the ATHEROREMO-IVUS study</title><title>Atherosclerosis</title><addtitle>Atherosclerosis</addtitle><description>Abstract Background and Aims Previous lipidomics analyses have demonstrated that several lipid molecules in plasma are associated with fatal outcome in patients with coronary artery disease (CAD). This study aims to investigate the associations of previously identified high risk lipid molecules in plasma with coronary plaque characteristics derived from intravascular ultrasound virtual histology (IVUS-VH) imaging, with coronary lipid core burden index (LCBI) on near-infrared spectroscopy (NIRS), and with one year cardiovascular outcome in patients with CAD. Methods Between 2008 and 2011, IVUS-VH imaging of a non-culprit coronary artery was performed in 581 patients who underwent coronary angiography for acute coronary syndrome (ACS) or stable CAD. NIRS imaging was additionally performed in 191 patients. Plasma concentrations of molecular lipids were measured with mass spectrometry. Results Several cholesteryl ester, ceramide and lactosylceramide species and ceramide ratios were associated with vulnerable plaque characteristics on IVUS-VH and NIRS imaging and with 1-year major adverse cardiac events (MACE, defined as all-cause mortality, ACS and unplanned coronary revascularization). In particular, ceramide d18:1/16:0 was consistently associated with higher necrotic core fraction on IVUS-VH (p = 0.001), higher LCBI (p = 0.024) on NIRS and higher MACE rate (adjusted HR 1.79 per standard deviation increase in log-transformed lipid concentration, 95%CI 1.24–2.59, p = 0.002). Conclusion Several molecular lipid species, and particularly ceramide(d18:1/16:0), are associated with the fraction of necrotic core tissue and lipid core burden in coronary atherosclerosis, and are predictive for 1-year clinical outcome after coronary angiography. These molecular lipids may improve risk stratification in CAD and may also be interesting therapeutic targets for the treatment of atherosclerotic disease.</description><subject>Acute Coronary Syndrome - blood</subject><subject>Acute Coronary Syndrome - diagnostic imaging</subject><subject>Acute Coronary Syndrome - mortality</subject><subject>Acute Coronary Syndrome - therapy</subject><subject>Aged</subject><subject>Atherosclerosis</subject><subject>Biomarkers - blood</subject><subject>Cardiovascular</subject><subject>Coronary Angiography</subject><subject>Coronary Artery Disease - blood</subject><subject>Coronary Artery Disease - diagnostic imaging</subject><subject>Coronary Artery Disease - mortality</subject><subject>Coronary Artery Disease - therapy</subject><subject>Coronary Vessels - diagnostic imaging</subject><subject>Coronary Vessels - metabolism</subject><subject>Disease Progression</subject><subject>Female</subject><subject>Humans</subject><subject>Intravascular ultrasound</subject><subject>Kaplan-Meier Estimate</subject><subject>Lipids</subject><subject>Lipids - blood</subject><subject>Male</subject><subject>Mass Spectrometry</subject><subject>Middle Aged</subject><subject>Myocardial Revascularization</subject><subject>Near-infrared spectroscopy</subject><subject>Necrosis</subject><subject>Netherlands</subject><subject>Plaque, Atherosclerotic</subject><subject>Predictive Value of Tests</subject><subject>Prognosis</subject><subject>Proportional Hazards Models</subject><subject>Risk Factors</subject><subject>Rupture, Spontaneous</subject><subject>Spectroscopy, Near-Infrared</subject><subject>Ultrasonography, Interventional</subject><issn>0021-9150</issn><issn>1879-1484</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNUk1vEzEUXCEQDYW_gHxB4rKpvV_OIoFUVaGtVBSUBq6W8_xWdfCug5-3Uv4NP7XepnDoiYt9eDPzNDMvyz4IPhdcNGe7uY53GDyBm15L84KLOs3mvCheZDOxkG0uqkX1MptxXoi8FTU_yd4Q7TjnlRSL19lJ0dRF2bbVLPvz3WnqNQM_AA4x6Gj9QMx3rPcOYXQ6MGf31jDaI1gkZgcW0D3iWPSJGPygw4Htnf49IoM7HTREDJaiBWJ6MAx0MNbfazrq-TGC7_ETWyONLj5uS57Y-eZquV6tl99W-fXPH7eM4mgOb7NXnXaE757-02zzdbm5uMpvVpfXF-c3OdSCx7zb1hIbiV1T1qiLxdY0vIMqzbQpOVZlJUEKg2XbbZumAllvRQMdBw1CtqY8zT4eZffBJxsUVW8J0Dk9oB9JCVnKSjZ1yRP08xEKKX8K2Kl9sH2KQAmupo7UTj3rSE0dTePUUeK_f1o1bns0_9h_S0mAyyMAk997i0FRSj71Y2xAiMp4-9-rvjxTAmcHC9r9wgPSzo9hSKEqoahQXN1OBzPdi0g-RbOoygcsTsWT</recordid><startdate>20151201</startdate><enddate>20151201</enddate><creator>Cheng, Jin M</creator><creator>Suoniemi, Matti</creator><creator>Kardys, Isabella</creator><creator>Vihervaara, Terhi</creator><creator>de Boer, Sanneke P.M</creator><creator>Akkerhuis, K. Martijn</creator><creator>Sysi-Aho, Marko</creator><creator>Ekroos, Kim</creator><creator>Garcia-Garcia, Hector M</creator><creator>Oemrawsingh, Rohit M</creator><creator>Regar, Evelyn</creator><creator>Koenig, Wolfgang</creator><creator>Serruys, Patrick W</creator><creator>van Geuns, Robert-Jan</creator><creator>Boersma, Eric</creator><creator>Laaksonen, Reijo</creator><general>Elsevier Ireland Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20151201</creationdate><title>Plasma concentrations of molecular lipid species in relation to coronary plaque characteristics and cardiovascular outcome: Results of the ATHEROREMO-IVUS study</title><author>Cheng, Jin M ; Suoniemi, Matti ; Kardys, Isabella ; Vihervaara, Terhi ; de Boer, Sanneke P.M ; Akkerhuis, K. Martijn ; Sysi-Aho, Marko ; Ekroos, Kim ; Garcia-Garcia, Hector M ; Oemrawsingh, Rohit M ; Regar, Evelyn ; Koenig, Wolfgang ; Serruys, Patrick W ; van Geuns, Robert-Jan ; Boersma, Eric ; Laaksonen, Reijo</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c510t-fb57e67ef635ea28bd60fc4510ad30e4347c71de39fb664c75b16cf0cac179d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Acute Coronary Syndrome - blood</topic><topic>Acute Coronary Syndrome - diagnostic imaging</topic><topic>Acute Coronary Syndrome - mortality</topic><topic>Acute Coronary Syndrome - therapy</topic><topic>Aged</topic><topic>Atherosclerosis</topic><topic>Biomarkers - blood</topic><topic>Cardiovascular</topic><topic>Coronary Angiography</topic><topic>Coronary Artery Disease - blood</topic><topic>Coronary Artery Disease - diagnostic imaging</topic><topic>Coronary Artery Disease - mortality</topic><topic>Coronary Artery Disease - therapy</topic><topic>Coronary Vessels - diagnostic imaging</topic><topic>Coronary Vessels - metabolism</topic><topic>Disease Progression</topic><topic>Female</topic><topic>Humans</topic><topic>Intravascular ultrasound</topic><topic>Kaplan-Meier Estimate</topic><topic>Lipids</topic><topic>Lipids - blood</topic><topic>Male</topic><topic>Mass Spectrometry</topic><topic>Middle Aged</topic><topic>Myocardial Revascularization</topic><topic>Near-infrared spectroscopy</topic><topic>Necrosis</topic><topic>Netherlands</topic><topic>Plaque, Atherosclerotic</topic><topic>Predictive Value of Tests</topic><topic>Prognosis</topic><topic>Proportional Hazards Models</topic><topic>Risk Factors</topic><topic>Rupture, Spontaneous</topic><topic>Spectroscopy, Near-Infrared</topic><topic>Ultrasonography, Interventional</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Cheng, Jin M</creatorcontrib><creatorcontrib>Suoniemi, Matti</creatorcontrib><creatorcontrib>Kardys, Isabella</creatorcontrib><creatorcontrib>Vihervaara, Terhi</creatorcontrib><creatorcontrib>de Boer, Sanneke P.M</creatorcontrib><creatorcontrib>Akkerhuis, K. Martijn</creatorcontrib><creatorcontrib>Sysi-Aho, Marko</creatorcontrib><creatorcontrib>Ekroos, Kim</creatorcontrib><creatorcontrib>Garcia-Garcia, Hector M</creatorcontrib><creatorcontrib>Oemrawsingh, Rohit M</creatorcontrib><creatorcontrib>Regar, Evelyn</creatorcontrib><creatorcontrib>Koenig, Wolfgang</creatorcontrib><creatorcontrib>Serruys, Patrick W</creatorcontrib><creatorcontrib>van Geuns, Robert-Jan</creatorcontrib><creatorcontrib>Boersma, Eric</creatorcontrib><creatorcontrib>Laaksonen, Reijo</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Atherosclerosis</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Cheng, Jin M</au><au>Suoniemi, Matti</au><au>Kardys, Isabella</au><au>Vihervaara, Terhi</au><au>de Boer, Sanneke P.M</au><au>Akkerhuis, K. Martijn</au><au>Sysi-Aho, Marko</au><au>Ekroos, Kim</au><au>Garcia-Garcia, Hector M</au><au>Oemrawsingh, Rohit M</au><au>Regar, Evelyn</au><au>Koenig, Wolfgang</au><au>Serruys, Patrick W</au><au>van Geuns, Robert-Jan</au><au>Boersma, Eric</au><au>Laaksonen, Reijo</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Plasma concentrations of molecular lipid species in relation to coronary plaque characteristics and cardiovascular outcome: Results of the ATHEROREMO-IVUS study</atitle><jtitle>Atherosclerosis</jtitle><addtitle>Atherosclerosis</addtitle><date>2015-12-01</date><risdate>2015</risdate><volume>243</volume><issue>2</issue><spage>560</spage><epage>566</epage><pages>560-566</pages><issn>0021-9150</issn><eissn>1879-1484</eissn><abstract>Abstract Background and Aims Previous lipidomics analyses have demonstrated that several lipid molecules in plasma are associated with fatal outcome in patients with coronary artery disease (CAD). This study aims to investigate the associations of previously identified high risk lipid molecules in plasma with coronary plaque characteristics derived from intravascular ultrasound virtual histology (IVUS-VH) imaging, with coronary lipid core burden index (LCBI) on near-infrared spectroscopy (NIRS), and with one year cardiovascular outcome in patients with CAD. Methods Between 2008 and 2011, IVUS-VH imaging of a non-culprit coronary artery was performed in 581 patients who underwent coronary angiography for acute coronary syndrome (ACS) or stable CAD. NIRS imaging was additionally performed in 191 patients. Plasma concentrations of molecular lipids were measured with mass spectrometry. Results Several cholesteryl ester, ceramide and lactosylceramide species and ceramide ratios were associated with vulnerable plaque characteristics on IVUS-VH and NIRS imaging and with 1-year major adverse cardiac events (MACE, defined as all-cause mortality, ACS and unplanned coronary revascularization). In particular, ceramide d18:1/16:0 was consistently associated with higher necrotic core fraction on IVUS-VH (p = 0.001), higher LCBI (p = 0.024) on NIRS and higher MACE rate (adjusted HR 1.79 per standard deviation increase in log-transformed lipid concentration, 95%CI 1.24–2.59, p = 0.002). Conclusion Several molecular lipid species, and particularly ceramide(d18:1/16:0), are associated with the fraction of necrotic core tissue and lipid core burden in coronary atherosclerosis, and are predictive for 1-year clinical outcome after coronary angiography. These molecular lipids may improve risk stratification in CAD and may also be interesting therapeutic targets for the treatment of atherosclerotic disease.</abstract><cop>Ireland</cop><pub>Elsevier Ireland Ltd</pub><pmid>26523994</pmid><doi>10.1016/j.atherosclerosis.2015.10.022</doi><tpages>7</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0021-9150 |
| ispartof | Atherosclerosis, 2015-12, Vol.243 (2), p.560-566 |
| issn | 0021-9150 1879-1484 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_1737476530 |
| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Acute Coronary Syndrome - blood Acute Coronary Syndrome - diagnostic imaging Acute Coronary Syndrome - mortality Acute Coronary Syndrome - therapy Aged Atherosclerosis Biomarkers - blood Cardiovascular Coronary Angiography Coronary Artery Disease - blood Coronary Artery Disease - diagnostic imaging Coronary Artery Disease - mortality Coronary Artery Disease - therapy Coronary Vessels - diagnostic imaging Coronary Vessels - metabolism Disease Progression Female Humans Intravascular ultrasound Kaplan-Meier Estimate Lipids Lipids - blood Male Mass Spectrometry Middle Aged Myocardial Revascularization Near-infrared spectroscopy Necrosis Netherlands Plaque, Atherosclerotic Predictive Value of Tests Prognosis Proportional Hazards Models Risk Factors Rupture, Spontaneous Spectroscopy, Near-Infrared Ultrasonography, Interventional |
| title | Plasma concentrations of molecular lipid species in relation to coronary plaque characteristics and cardiovascular outcome: Results of the ATHEROREMO-IVUS study |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-03T08%3A59%3A41IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Plasma%20concentrations%20of%20molecular%20lipid%20species%20in%20relation%20to%20coronary%20plaque%20characteristics%20and%20cardiovascular%20outcome:%20Results%20of%20the%20ATHEROREMO-IVUS%20study&rft.jtitle=Atherosclerosis&rft.au=Cheng,%20Jin%20M&rft.date=2015-12-01&rft.volume=243&rft.issue=2&rft.spage=560&rft.epage=566&rft.pages=560-566&rft.issn=0021-9150&rft.eissn=1879-1484&rft_id=info:doi/10.1016/j.atherosclerosis.2015.10.022&rft_dat=%3Cproquest_cross%3E1737476530%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1737476530&rft_id=info:pmid/26523994&rft_els_id=S0021915015301684&rfr_iscdi=true |