Identification of small-molecule inhibitors against SecA by structure-based virtual ligand screening

The rapid rise of antibiotic-resistant bacteria is one of the major concerns in modern medicine. Therefore, to treat bacterial infections, there is an urgent need for new antibacterials–preferably directed against alternative bacterial targets. One such potential target is the preprotein translocati...

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Veröffentlicht in:Journal of antibiotics 2015-11, Vol.68 (11), p.666-673
Hauptverfasser: De Waelheyns, Evelien, Segers, Kenneth, Sardis, Marios Frantzeskos, Anné, Jozef, Nicolaes, Gerry A F, Economou, Anastassios
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Sprache:eng
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