Heavy Atom Isotope Effects Reveal a Highly Polarized Transition State for Chorismate Mutase

The conversion of chorismate (1) to prephenate (2) is catalyzed by the enzyme chorismate mutase. The enzymatic reaction is formally a Claisen rearrangement, proceeding through a chairlike transition state, but more detailed information on the structure of this high-energy species has remained elusiv...

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Veröffentlicht in:	Journal of the American Chemical Society 1999-03, Vol.121 (8), p.1756-1757
Hauptverfasser:	Gustin, Darin J, Mattei, Patrizio, Kast, Peter, Wiest, Olaf, Lee, Lac, Cleland, W. Wallace, Hilvert, Donald
Format:	Artikel
Sprache:	eng
Schlagworte:	Escherichia coli
Online-Zugang:	Volltext
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