Adenosine receptors co-operate with NMDA preconditioning to protect cerebellar granule cells against glutamate neurotoxicity

N-Methyl- d-aspartate (NMDA) preconditioning is evoked by subtoxic concentrations of NMDA (50 μM), which has been shown previously to lead to transient resistance to subsequent lethal dose of glutamate or NMDA in cultured neurons. The purpose of this study was to investigate the participation of ade...

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Veröffentlicht in:	Neuropharmacology 2005-07, Vol.49 (1), p.17-24
Hauptverfasser:	Boeck, Carina R., Kroth, Eduardo H., Bronzatto, Mauro J., Vendite, Deusa
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenosine Adenosine Diphosphate - metabolism Adenosine Triphosphatases - metabolism Animals Animals, Newborn Cell Death - drug effects Cells, Cultured Cerebellar granule cells Cerebellum - cytology Cyclic AMP - metabolism Drug Antagonism Excitatory Amino Acid Agonists - pharmacology Glutamate neurotoxicity Glutamic Acid - toxicity Hydrolysis - drug effects N-Methylaspartate - pharmacology Neurons - drug effects Neurons - physiology Neuroprotection NMDA preconditioning Purinergic P1 Receptor Agonists Purinergic P1 Receptor Antagonists Rats Rats, Wistar Receptors, Purinergic P1 - physiology Theophylline - analogs & derivatives Theophylline - pharmacology Triazines - pharmacology Triazoles - pharmacology
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