Association of Dental Caries and Blood Lead Levels
CONTEXT Experiments show that dental caries rates are higher among lead-exposed animals, but this association has not been established in humans. OBJECTIVE To examine the relationship between blood lead levels and dental caries. DESIGN Cross-sectional survey conducted from 1988 to 1994 that included...
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| Veröffentlicht in: | JAMA : the journal of the American Medical Association 1999-06, Vol.281 (24), p.2294-2298 |
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| creator | Moss, Mark E Lanphear, Bruce P Auinger, Peggy |
| description | CONTEXT Experiments show that dental caries rates are higher
among lead-exposed animals, but this association has not been
established in humans. OBJECTIVE To examine the relationship between blood lead levels
and dental caries. DESIGN Cross-sectional survey conducted from 1988 to 1994 that
included a dental examination and venipuncture blood lead assay. SETTING AND PARTICIPANTS A total of 24,901 persons aged 2
years and older who participated in the Third National Health and
Nutrition Examination Survey, which assessed the health and nutritional
status of children and adults in the United States. MAIN OUTCOME MEASURES For children aged 2 to 11 years, the sum of
decayed and filled deciduous or primary surfaces; for persons aged 6
years and older, the sum of decayed and filled permanent surfaces; for
those 12 years and older, the sum of decayed, missing, and filled
surfaces. RESULTS The log of blood lead level was significantly
associated with the number of affected surfaces for both deciduous and
permanent teeth in all age groups, even after adjusting for
sociodemographic characteristics, diet, and dental care. Among children
aged 5 to 17 years, a 0.24-µmol/L (5-µg/dL) change in blood lead
level was associated with an elevated risk of dental caries (odds
ratio, 1.8; 95% confidence interval, 1.3-2.5). Differences in blood
lead level explained some of the differences in caries prevalence in
different income levels and regions of the United States. We estimated
the population attributable risk of lead exposure to be 13.5% and
9.6% of dental caries occurring in 5- to 17-year-olds exposed to the
high and moderate levels, respectively. CONCLUSIONS Environmental lead exposure is associated with an
increased prevalence of dental caries in the US population. Findings
may help explain the distribution of caries by income and region of the
United States. |
| doi_str_mv | 10.1001/jama.281.24.2294 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_proquest_miscellaneous_17368443</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><ama_id>190537</ama_id><sourcerecordid>17368443</sourcerecordid><originalsourceid>FETCH-LOGICAL-a359t-55fac6e036aea39a38c52b9e582770e05726dd5b3a5e4f3d1d0c5ae6ed0a96663</originalsourceid><addsrcrecordid>eNpd0EtLw0AQAOBFFFurd71IEPGWuLuzz2OtTyh40XOYZjeQkmRrNhH896a0UnAOM4f5mBmGkEtGM0Ypu19jgxk3LOMi49yKIzJlEkwK0ppjMqXUmlQLIybkLMY1HYOBPiUTRsEoKWFK-DzGUFTYV6FNQpk8-rbHOllgV_mYYOuShzoElyw9btO3r-M5OSmxjv5iX2fk8_npY_GaLt9f3hbzZYrj-j6VssRCeQoKPYJFMIXkK-ul4VpTT6Xmyjm5ApRelOCYo4VEr7yjaJVSMCN3u7mbLnwNPvZ5U8XC1zW2PgwxZxqUEQJGePMPrsPQteNtOWeMW8phi673aFg13uWbrmqw-8n_XjGC2z3AWGBddtgWVTw4o6gWcmRXOza-_tC0VIKGX4Sdcxw</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>211290233</pqid></control><display><type>article</type><title>Association of Dental Caries and Blood Lead Levels</title><source>MEDLINE</source><source>American Medical Association Journals</source><creator>Moss, Mark E ; Lanphear, Bruce P ; Auinger, Peggy</creator><creatorcontrib>Moss, Mark E ; Lanphear, Bruce P ; Auinger, Peggy</creatorcontrib><description>CONTEXT Experiments show that dental caries rates are higher
among lead-exposed animals, but this association has not been
established in humans. OBJECTIVE To examine the relationship between blood lead levels
and dental caries. DESIGN Cross-sectional survey conducted from 1988 to 1994 that
included a dental examination and venipuncture blood lead assay. SETTING AND PARTICIPANTS A total of 24,901 persons aged 2
years and older who participated in the Third National Health and
Nutrition Examination Survey, which assessed the health and nutritional
status of children and adults in the United States. MAIN OUTCOME MEASURES For children aged 2 to 11 years, the sum of
decayed and filled deciduous or primary surfaces; for persons aged 6
years and older, the sum of decayed and filled permanent surfaces; for
those 12 years and older, the sum of decayed, missing, and filled
surfaces. RESULTS The log of blood lead level was significantly
associated with the number of affected surfaces for both deciduous and
permanent teeth in all age groups, even after adjusting for
sociodemographic characteristics, diet, and dental care. Among children
aged 5 to 17 years, a 0.24-µmol/L (5-µg/dL) change in blood lead
level was associated with an elevated risk of dental caries (odds
ratio, 1.8; 95% confidence interval, 1.3-2.5). Differences in blood
lead level explained some of the differences in caries prevalence in
different income levels and regions of the United States. We estimated
the population attributable risk of lead exposure to be 13.5% and
9.6% of dental caries occurring in 5- to 17-year-olds exposed to the
high and moderate levels, respectively. CONCLUSIONS Environmental lead exposure is associated with an
increased prevalence of dental caries in the US population. Findings
may help explain the distribution of caries by income and region of the
United States.</description><identifier>ISSN: 0098-7484</identifier><identifier>EISSN: 1538-3598</identifier><identifier>DOI: 10.1001/jama.281.24.2294</identifier><identifier>PMID: 10386553</identifier><identifier>CODEN: JAMAAP</identifier><language>eng</language><publisher>Chicago, IL: American Medical Association</publisher><subject>Adolescent ; Adult ; Biological and medical sciences ; Blood ; Child ; Child, Preschool ; Cross-Sectional Studies ; Dental Caries - blood ; Dental Caries - epidemiology ; Environmental Exposure ; Facial bones, jaws, teeth, parodontium: diseases, semeiology ; Female ; Health risk assessment ; Health Surveys ; Humans ; Lead - blood ; Lead poisoning ; Logistic Models ; Male ; Medical sciences ; Mouth ; Multivariate Analysis ; Non tumoral diseases ; Otorhinolaryngology. Stomatology ; Risk Factors ; Socioeconomic Factors ; Teeth ; United States - epidemiology</subject><ispartof>JAMA : the journal of the American Medical Association, 1999-06, Vol.281 (24), p.2294-2298</ispartof><rights>1999 INIST-CNRS</rights><rights>Copyright American Medical Association Jun 23/Jun 30, 1999</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-a359t-55fac6e036aea39a38c52b9e582770e05726dd5b3a5e4f3d1d0c5ae6ed0a96663</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://jamanetwork.com/journals/jama/articlepdf/10.1001/jama.281.24.2294$$EPDF$$P50$$Gama$$H</linktopdf><linktohtml>$$Uhttps://jamanetwork.com/journals/jama/fullarticle/10.1001/jama.281.24.2294$$EHTML$$P50$$Gama$$H</linktohtml><link.rule.ids>64,314,777,781,3327,27905,27906,76238,76241</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=1860745$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/10386553$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Moss, Mark E</creatorcontrib><creatorcontrib>Lanphear, Bruce P</creatorcontrib><creatorcontrib>Auinger, Peggy</creatorcontrib><title>Association of Dental Caries and Blood Lead Levels</title><title>JAMA : the journal of the American Medical Association</title><addtitle>JAMA</addtitle><description>CONTEXT Experiments show that dental caries rates are higher
among lead-exposed animals, but this association has not been
established in humans. OBJECTIVE To examine the relationship between blood lead levels
and dental caries. DESIGN Cross-sectional survey conducted from 1988 to 1994 that
included a dental examination and venipuncture blood lead assay. SETTING AND PARTICIPANTS A total of 24,901 persons aged 2
years and older who participated in the Third National Health and
Nutrition Examination Survey, which assessed the health and nutritional
status of children and adults in the United States. MAIN OUTCOME MEASURES For children aged 2 to 11 years, the sum of
decayed and filled deciduous or primary surfaces; for persons aged 6
years and older, the sum of decayed and filled permanent surfaces; for
those 12 years and older, the sum of decayed, missing, and filled
surfaces. RESULTS The log of blood lead level was significantly
associated with the number of affected surfaces for both deciduous and
permanent teeth in all age groups, even after adjusting for
sociodemographic characteristics, diet, and dental care. Among children
aged 5 to 17 years, a 0.24-µmol/L (5-µg/dL) change in blood lead
level was associated with an elevated risk of dental caries (odds
ratio, 1.8; 95% confidence interval, 1.3-2.5). Differences in blood
lead level explained some of the differences in caries prevalence in
different income levels and regions of the United States. We estimated
the population attributable risk of lead exposure to be 13.5% and
9.6% of dental caries occurring in 5- to 17-year-olds exposed to the
high and moderate levels, respectively. CONCLUSIONS Environmental lead exposure is associated with an
increased prevalence of dental caries in the US population. Findings
may help explain the distribution of caries by income and region of the
United States.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Biological and medical sciences</subject><subject>Blood</subject><subject>Child</subject><subject>Child, Preschool</subject><subject>Cross-Sectional Studies</subject><subject>Dental Caries - blood</subject><subject>Dental Caries - epidemiology</subject><subject>Environmental Exposure</subject><subject>Facial bones, jaws, teeth, parodontium: diseases, semeiology</subject><subject>Female</subject><subject>Health risk assessment</subject><subject>Health Surveys</subject><subject>Humans</subject><subject>Lead - blood</subject><subject>Lead poisoning</subject><subject>Logistic Models</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Mouth</subject><subject>Multivariate Analysis</subject><subject>Non tumoral diseases</subject><subject>Otorhinolaryngology. Stomatology</subject><subject>Risk Factors</subject><subject>Socioeconomic Factors</subject><subject>Teeth</subject><subject>United States - epidemiology</subject><issn>0098-7484</issn><issn>1538-3598</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1999</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpd0EtLw0AQAOBFFFurd71IEPGWuLuzz2OtTyh40XOYZjeQkmRrNhH896a0UnAOM4f5mBmGkEtGM0Ypu19jgxk3LOMi49yKIzJlEkwK0ppjMqXUmlQLIybkLMY1HYOBPiUTRsEoKWFK-DzGUFTYV6FNQpk8-rbHOllgV_mYYOuShzoElyw9btO3r-M5OSmxjv5iX2fk8_npY_GaLt9f3hbzZYrj-j6VssRCeQoKPYJFMIXkK-ul4VpTT6Xmyjm5ApRelOCYo4VEr7yjaJVSMCN3u7mbLnwNPvZ5U8XC1zW2PgwxZxqUEQJGePMPrsPQteNtOWeMW8phi673aFg13uWbrmqw-8n_XjGC2z3AWGBddtgWVTw4o6gWcmRXOza-_tC0VIKGX4Sdcxw</recordid><startdate>19990623</startdate><enddate>19990623</enddate><creator>Moss, Mark E</creator><creator>Lanphear, Bruce P</creator><creator>Auinger, Peggy</creator><general>American Medical Association</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7QL</scope><scope>7QP</scope><scope>7TK</scope><scope>7TS</scope><scope>7U7</scope><scope>7U9</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>H94</scope><scope>K9.</scope><scope>M7N</scope><scope>NAPCQ</scope><scope>P64</scope><scope>RC3</scope></search><sort><creationdate>19990623</creationdate><title>Association of Dental Caries and Blood Lead Levels</title><author>Moss, Mark E ; Lanphear, Bruce P ; Auinger, Peggy</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-a359t-55fac6e036aea39a38c52b9e582770e05726dd5b3a5e4f3d1d0c5ae6ed0a96663</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1999</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Biological and medical sciences</topic><topic>Blood</topic><topic>Child</topic><topic>Child, Preschool</topic><topic>Cross-Sectional Studies</topic><topic>Dental Caries - blood</topic><topic>Dental Caries - epidemiology</topic><topic>Environmental Exposure</topic><topic>Facial bones, jaws, teeth, parodontium: diseases, semeiology</topic><topic>Female</topic><topic>Health risk assessment</topic><topic>Health Surveys</topic><topic>Humans</topic><topic>Lead - blood</topic><topic>Lead poisoning</topic><topic>Logistic Models</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Mouth</topic><topic>Multivariate Analysis</topic><topic>Non tumoral diseases</topic><topic>Otorhinolaryngology. Stomatology</topic><topic>Risk Factors</topic><topic>Socioeconomic Factors</topic><topic>Teeth</topic><topic>United States - epidemiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Moss, Mark E</creatorcontrib><creatorcontrib>Lanphear, Bruce P</creatorcontrib><creatorcontrib>Auinger, Peggy</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Physical Education Index</collection><collection>Toxicology Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Nursing & Allied Health Premium</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><jtitle>JAMA : the journal of the American Medical Association</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Moss, Mark E</au><au>Lanphear, Bruce P</au><au>Auinger, Peggy</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Association of Dental Caries and Blood Lead Levels</atitle><jtitle>JAMA : the journal of the American Medical Association</jtitle><addtitle>JAMA</addtitle><date>1999-06-23</date><risdate>1999</risdate><volume>281</volume><issue>24</issue><spage>2294</spage><epage>2298</epage><pages>2294-2298</pages><issn>0098-7484</issn><eissn>1538-3598</eissn><coden>JAMAAP</coden><abstract>CONTEXT Experiments show that dental caries rates are higher
among lead-exposed animals, but this association has not been
established in humans. OBJECTIVE To examine the relationship between blood lead levels
and dental caries. DESIGN Cross-sectional survey conducted from 1988 to 1994 that
included a dental examination and venipuncture blood lead assay. SETTING AND PARTICIPANTS A total of 24,901 persons aged 2
years and older who participated in the Third National Health and
Nutrition Examination Survey, which assessed the health and nutritional
status of children and adults in the United States. MAIN OUTCOME MEASURES For children aged 2 to 11 years, the sum of
decayed and filled deciduous or primary surfaces; for persons aged 6
years and older, the sum of decayed and filled permanent surfaces; for
those 12 years and older, the sum of decayed, missing, and filled
surfaces. RESULTS The log of blood lead level was significantly
associated with the number of affected surfaces for both deciduous and
permanent teeth in all age groups, even after adjusting for
sociodemographic characteristics, diet, and dental care. Among children
aged 5 to 17 years, a 0.24-µmol/L (5-µg/dL) change in blood lead
level was associated with an elevated risk of dental caries (odds
ratio, 1.8; 95% confidence interval, 1.3-2.5). Differences in blood
lead level explained some of the differences in caries prevalence in
different income levels and regions of the United States. We estimated
the population attributable risk of lead exposure to be 13.5% and
9.6% of dental caries occurring in 5- to 17-year-olds exposed to the
high and moderate levels, respectively. CONCLUSIONS Environmental lead exposure is associated with an
increased prevalence of dental caries in the US population. Findings
may help explain the distribution of caries by income and region of the
United States.</abstract><cop>Chicago, IL</cop><pub>American Medical Association</pub><pmid>10386553</pmid><doi>10.1001/jama.281.24.2294</doi><tpages>5</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0098-7484 |
| ispartof | JAMA : the journal of the American Medical Association, 1999-06, Vol.281 (24), p.2294-2298 |
| issn | 0098-7484 1538-3598 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_17368443 |
| source | MEDLINE; American Medical Association Journals |
| subjects | Adolescent Adult Biological and medical sciences Blood Child Child, Preschool Cross-Sectional Studies Dental Caries - blood Dental Caries - epidemiology Environmental Exposure Facial bones, jaws, teeth, parodontium: diseases, semeiology Female Health risk assessment Health Surveys Humans Lead - blood Lead poisoning Logistic Models Male Medical sciences Mouth Multivariate Analysis Non tumoral diseases Otorhinolaryngology. Stomatology Risk Factors Socioeconomic Factors Teeth United States - epidemiology |
| title | Association of Dental Caries and Blood Lead Levels |
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