PRACTICAL APPLICATION OF GUINEA PIG TELEMETRY SYSTEM FOR QT EVALUATION

The purpose of this study was to evaluate a telemetry system for examining QT evaluation in the conscious free-moving guinea pig using 10 reference compounds whose effects on human QT interval are well established: 8 positive references (bepridil, terfenadine, cisapride, haloperidol, pimozide, quini...

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Veröffentlicht in:	Journal of toxicological sciences 2005, Vol.30(3), pp.239-247
Hauptverfasser:	SHIOTANI, Motohiro, HARADA, Takuma, ABE, Junko, SAWADA, Yasufusa, HASHIMOTO, Keitaro, HAMADA, Yoshimasa, HORII, Ikuo
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Anti-Arrhythmia Agents - administration & dosage Anti-Arrhythmia Agents - blood Anti-Arrhythmia Agents - pharmacokinetics Antipsychotic Agents - administration & dosage Antipsychotic Agents - blood Antipsychotic Agents - pharmacokinetics Bepridil - administration & dosage Bepridil - blood Bepridil - pharmacokinetics Cisapride - administration & dosage Cisapride - blood Cisapride - pharmacokinetics Disease Models, Animal Electrocardiography - methods Guinea pig Guinea Pigs Haloperidol - administration & dosage Haloperidol - blood Haloperidol - pharmacokinetics Heart - drug effects Heart - physiology Heart - physiopathology Humans In vivo Injections, Intravenous Long QT Syndrome - chemically induced Long QT Syndrome - diagnosis Long QT Syndrome - physiopathology Male Nifedipine - administration & dosage Nifedipine - blood Nifedipine - pharmacokinetics Pimozide - administration & dosage Pimozide - blood Pimozide - pharmacokinetics Piperidines - administration & dosage Piperidines - blood Piperidines - pharmacokinetics Pyridines - administration & dosage Pyridines - blood Pyridines - pharmacokinetics QT interval QTc Quinidine - administration & dosage Quinidine - blood Quinidine - pharmacokinetics Reproducibility of Results Telemetry - methods Telemetry system Terfenadine - administration & dosage Terfenadine - blood Terfenadine - pharmacokinetics Thioridazine - administration & dosage Thioridazine - blood Thioridazine - pharmacokinetics
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