Self-Targeted, Shape-Assisted, and Controlled-Release Self-Delivery Nanodrug for Synergistic Targeting/Anticancer Effect of Cytoplasm and Nucleus of Cancer Cells
We constructed 10-hydroxycamptothecin (CPT) “nanodrugs” with functionalization of lipid-PEG-methotrexate (MTX) to prepare high-drug-loaded, and sustained/controlled-release MTX-PEG-CPT nanorods (NRs), in which MTX drug itself can serve as a specific “targeting ligand”. The self-targeted nanodrug can...
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| Veröffentlicht in: | ACS applied materials & interfaces 2015-11, Vol.7 (46), p.25553-25559 |
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| container_title | ACS applied materials & interfaces |
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| creator | Li, Yang Lin, Jinyan Huang, Yu Li, Yanxiu Yang, Xiangrui Wu, Hongjie Wu, Shichao Xie, Liya Dai, Lizong Hou, Zhenqing |
| description | We constructed 10-hydroxycamptothecin (CPT) “nanodrugs” with functionalization of lipid-PEG-methotrexate (MTX) to prepare high-drug-loaded, and sustained/controlled-release MTX-PEG-CPT nanorods (NRs), in which MTX drug itself can serve as a specific “targeting ligand”. The self-targeted nanodrug can codeliver both CPT and MTX drugs with distinct anticancer mechanisms. Furthermore, MTX-PEG-CPT NRs significantly reduced burst release, improved blood circulation and tumor accumulation, enhanced cellular uptake, and synergistically increased anticancer effect against tumor cells compared with MTX-PEG-CPT nanospheres (NSs) and either both free drugs or individual free drug. Therefore, the synergistic targeting/therapeuticy nano-multi-drug codelivery assisted by shape design may advantageously offer a promising new strategy for nanomedicine. |
| doi_str_mv | 10.1021/acsami.5b07348 |
| format | Article |
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The self-targeted nanodrug can codeliver both CPT and MTX drugs with distinct anticancer mechanisms. Furthermore, MTX-PEG-CPT NRs significantly reduced burst release, improved blood circulation and tumor accumulation, enhanced cellular uptake, and synergistically increased anticancer effect against tumor cells compared with MTX-PEG-CPT nanospheres (NSs) and either both free drugs or individual free drug. Therefore, the synergistic targeting/therapeuticy nano-multi-drug codelivery assisted by shape design may advantageously offer a promising new strategy for nanomedicine.</description><identifier>ISSN: 1944-8244</identifier><identifier>EISSN: 1944-8252</identifier><identifier>DOI: 10.1021/acsami.5b07348</identifier><identifier>PMID: 26529185</identifier><language>eng</language><publisher>United States: American Chemical Society</publisher><subject>Animals ; Antineoplastic Agents - pharmacology ; Camptothecin - analogs & derivatives ; Camptothecin - pharmacology ; Cell Line, Tumor ; Cell Nucleus - drug effects ; Cell Nucleus - metabolism ; Cell Survival - drug effects ; Delayed-Action Preparations ; Drug Synergism ; Endocytosis - drug effects ; Fluorescence ; Methotrexate - pharmacology ; Mice, Inbred BALB C ; Mice, Nude ; Nanospheres - chemistry ; Nanospheres - ultrastructure ; Nanotubes - chemistry ; Nanotubes - ultrastructure ; Particle Size ; Rats, Sprague-Dawley</subject><ispartof>ACS applied materials & interfaces, 2015-11, Vol.7 (46), p.25553-25559</ispartof><rights>Copyright © 2015 American Chemical Society</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-a330t-3d076106f576dab6e05fd61e57711b00aba91ea21a91122658bd992d540f32ce3</citedby><cites>FETCH-LOGICAL-a330t-3d076106f576dab6e05fd61e57711b00aba91ea21a91122658bd992d540f32ce3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://pubs.acs.org/doi/pdf/10.1021/acsami.5b07348$$EPDF$$P50$$Gacs$$H</linktopdf><linktohtml>$$Uhttps://pubs.acs.org/doi/10.1021/acsami.5b07348$$EHTML$$P50$$Gacs$$H</linktohtml><link.rule.ids>314,780,784,2765,27076,27924,27925,56738,56788</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26529185$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Li, Yang</creatorcontrib><creatorcontrib>Lin, Jinyan</creatorcontrib><creatorcontrib>Huang, Yu</creatorcontrib><creatorcontrib>Li, Yanxiu</creatorcontrib><creatorcontrib>Yang, Xiangrui</creatorcontrib><creatorcontrib>Wu, Hongjie</creatorcontrib><creatorcontrib>Wu, Shichao</creatorcontrib><creatorcontrib>Xie, Liya</creatorcontrib><creatorcontrib>Dai, Lizong</creatorcontrib><creatorcontrib>Hou, Zhenqing</creatorcontrib><title>Self-Targeted, Shape-Assisted, and Controlled-Release Self-Delivery Nanodrug for Synergistic Targeting/Anticancer Effect of Cytoplasm and Nucleus of Cancer Cells</title><title>ACS applied materials & interfaces</title><addtitle>ACS Appl. Mater. Interfaces</addtitle><description>We constructed 10-hydroxycamptothecin (CPT) “nanodrugs” with functionalization of lipid-PEG-methotrexate (MTX) to prepare high-drug-loaded, and sustained/controlled-release MTX-PEG-CPT nanorods (NRs), in which MTX drug itself can serve as a specific “targeting ligand”. The self-targeted nanodrug can codeliver both CPT and MTX drugs with distinct anticancer mechanisms. Furthermore, MTX-PEG-CPT NRs significantly reduced burst release, improved blood circulation and tumor accumulation, enhanced cellular uptake, and synergistically increased anticancer effect against tumor cells compared with MTX-PEG-CPT nanospheres (NSs) and either both free drugs or individual free drug. Therefore, the synergistic targeting/therapeuticy nano-multi-drug codelivery assisted by shape design may advantageously offer a promising new strategy for nanomedicine.</description><subject>Animals</subject><subject>Antineoplastic Agents - pharmacology</subject><subject>Camptothecin - analogs & derivatives</subject><subject>Camptothecin - pharmacology</subject><subject>Cell Line, Tumor</subject><subject>Cell Nucleus - drug effects</subject><subject>Cell Nucleus - metabolism</subject><subject>Cell Survival - drug effects</subject><subject>Delayed-Action Preparations</subject><subject>Drug Synergism</subject><subject>Endocytosis - drug effects</subject><subject>Fluorescence</subject><subject>Methotrexate - pharmacology</subject><subject>Mice, Inbred BALB C</subject><subject>Mice, Nude</subject><subject>Nanospheres - chemistry</subject><subject>Nanospheres - ultrastructure</subject><subject>Nanotubes - chemistry</subject><subject>Nanotubes - ultrastructure</subject><subject>Particle Size</subject><subject>Rats, Sprague-Dawley</subject><issn>1944-8244</issn><issn>1944-8252</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kUFP3DAQha0KVCj0yrHyEVXNYjuxszmuUloqIZBYeo4m8XgJcuytnVTan9N_WrNZuHEaj-Z7zx4_Qi44W3Am-BV0EYZ-IVtW5sXyAznlVVFkSyHF0du5KE7IpxifGVO5YPIjORFKioov5Sn5t0ZrskcIGxxRf6PrJ9hitoqxj_senKa1d2Pw1qLOHtAiRKR71Xe0_V8MO3oHzuswbajxga53DsMmyfuOzr6921ytXOrBdRjotTHYjdQbWu9Gv7UQh_01d1NncYr7wUzWaG08J8cGbMTPh3pGfv-4fqxvstv7n7_q1W0Gec7GLNesVJwpI0uloVXIpNGKoyxLzlvGoIWKIwieChfpA5atriqhZcFMLjrMz8jl7LsN_s-EcWyGPnbpBeDQT7HhZa5UWclCJHQxo13wMQY0zTb0A4Rdw1nzEkszx9IcYkmCLwfvqR1Qv-GvOSTg6wwkYfPsp-DSqu-5_Qf8M5lW</recordid><startdate>20151125</startdate><enddate>20151125</enddate><creator>Li, Yang</creator><creator>Lin, Jinyan</creator><creator>Huang, Yu</creator><creator>Li, Yanxiu</creator><creator>Yang, Xiangrui</creator><creator>Wu, Hongjie</creator><creator>Wu, Shichao</creator><creator>Xie, Liya</creator><creator>Dai, Lizong</creator><creator>Hou, Zhenqing</creator><general>American Chemical Society</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20151125</creationdate><title>Self-Targeted, Shape-Assisted, and Controlled-Release Self-Delivery Nanodrug for Synergistic Targeting/Anticancer Effect of Cytoplasm and Nucleus of Cancer Cells</title><author>Li, Yang ; Lin, Jinyan ; Huang, Yu ; Li, Yanxiu ; Yang, Xiangrui ; Wu, Hongjie ; Wu, Shichao ; Xie, Liya ; Dai, Lizong ; Hou, Zhenqing</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-a330t-3d076106f576dab6e05fd61e57711b00aba91ea21a91122658bd992d540f32ce3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Animals</topic><topic>Antineoplastic Agents - pharmacology</topic><topic>Camptothecin - analogs & derivatives</topic><topic>Camptothecin - pharmacology</topic><topic>Cell Line, Tumor</topic><topic>Cell Nucleus - drug effects</topic><topic>Cell Nucleus - metabolism</topic><topic>Cell Survival - drug effects</topic><topic>Delayed-Action Preparations</topic><topic>Drug Synergism</topic><topic>Endocytosis - drug effects</topic><topic>Fluorescence</topic><topic>Methotrexate - pharmacology</topic><topic>Mice, Inbred BALB C</topic><topic>Mice, Nude</topic><topic>Nanospheres - chemistry</topic><topic>Nanospheres - ultrastructure</topic><topic>Nanotubes - chemistry</topic><topic>Nanotubes - ultrastructure</topic><topic>Particle Size</topic><topic>Rats, Sprague-Dawley</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Li, Yang</creatorcontrib><creatorcontrib>Lin, Jinyan</creatorcontrib><creatorcontrib>Huang, Yu</creatorcontrib><creatorcontrib>Li, Yanxiu</creatorcontrib><creatorcontrib>Yang, Xiangrui</creatorcontrib><creatorcontrib>Wu, Hongjie</creatorcontrib><creatorcontrib>Wu, Shichao</creatorcontrib><creatorcontrib>Xie, Liya</creatorcontrib><creatorcontrib>Dai, Lizong</creatorcontrib><creatorcontrib>Hou, Zhenqing</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>ACS applied materials & interfaces</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Li, Yang</au><au>Lin, Jinyan</au><au>Huang, Yu</au><au>Li, Yanxiu</au><au>Yang, Xiangrui</au><au>Wu, Hongjie</au><au>Wu, Shichao</au><au>Xie, Liya</au><au>Dai, Lizong</au><au>Hou, Zhenqing</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Self-Targeted, Shape-Assisted, and Controlled-Release Self-Delivery Nanodrug for Synergistic Targeting/Anticancer Effect of Cytoplasm and Nucleus of Cancer Cells</atitle><jtitle>ACS applied materials & interfaces</jtitle><addtitle>ACS Appl. Mater. Interfaces</addtitle><date>2015-11-25</date><risdate>2015</risdate><volume>7</volume><issue>46</issue><spage>25553</spage><epage>25559</epage><pages>25553-25559</pages><issn>1944-8244</issn><eissn>1944-8252</eissn><abstract>We constructed 10-hydroxycamptothecin (CPT) “nanodrugs” with functionalization of lipid-PEG-methotrexate (MTX) to prepare high-drug-loaded, and sustained/controlled-release MTX-PEG-CPT nanorods (NRs), in which MTX drug itself can serve as a specific “targeting ligand”. The self-targeted nanodrug can codeliver both CPT and MTX drugs with distinct anticancer mechanisms. Furthermore, MTX-PEG-CPT NRs significantly reduced burst release, improved blood circulation and tumor accumulation, enhanced cellular uptake, and synergistically increased anticancer effect against tumor cells compared with MTX-PEG-CPT nanospheres (NSs) and either both free drugs or individual free drug. Therefore, the synergistic targeting/therapeuticy nano-multi-drug codelivery assisted by shape design may advantageously offer a promising new strategy for nanomedicine.</abstract><cop>United States</cop><pub>American Chemical Society</pub><pmid>26529185</pmid><doi>10.1021/acsami.5b07348</doi><tpages>7</tpages></addata></record> |
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| subjects | Animals Antineoplastic Agents - pharmacology Camptothecin - analogs & derivatives Camptothecin - pharmacology Cell Line, Tumor Cell Nucleus - drug effects Cell Nucleus - metabolism Cell Survival - drug effects Delayed-Action Preparations Drug Synergism Endocytosis - drug effects Fluorescence Methotrexate - pharmacology Mice, Inbred BALB C Mice, Nude Nanospheres - chemistry Nanospheres - ultrastructure Nanotubes - chemistry Nanotubes - ultrastructure Particle Size Rats, Sprague-Dawley |
| title | Self-Targeted, Shape-Assisted, and Controlled-Release Self-Delivery Nanodrug for Synergistic Targeting/Anticancer Effect of Cytoplasm and Nucleus of Cancer Cells |
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