Sinonasal renal cell–like adenocarcinomas: robust carbonic anhydrase expression
Summary We report 3 new patients with sinonasal renal cell–like adenocarcinoma (SNRCLA). One case submitted in consultation demonstrated robust carbonic anhydrase IX (CA-IX) expression, leading us to a broader inquiry of CA-IX and carbonic anhydrase II (CA-II) expression in other SNRCLA, Schneideria...
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| Veröffentlicht in: | Human pathology 2015-11, Vol.46 (11), p.1598-1606 |
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| creator | Shen, Tiansheng, MD, PhD Shi, Qiuying, MD Velosa, Claudia, MD Bai, Shuting, MD, PhD Thompson, Lester, MD Simpson, Roderick, MD Wei, Shi, MD, PhD Brandwein-Gensler, Margaret, MD |
| description | Summary We report 3 new patients with sinonasal renal cell–like adenocarcinoma (SNRCLA). One case submitted in consultation demonstrated robust carbonic anhydrase IX (CA-IX) expression, leading us to a broader inquiry of CA-IX and carbonic anhydrase II (CA-II) expression in other SNRCLA, Schneiderian tissues, and histologic mimickers. Robust cytoplasmic and membranous CA-IX expression is demonstrated in 6 of 7 SNRCLAs; CA-II expression was demonstrated in 2 of 5 cases. Robust, diffuse CA-II expression is demonstrated throughout sinonasal seromucinous glands in all 10 normal Schneiderian samples. CA-IX is also expressed in all normal sinonasal samples, albeit focally. The closest salivary mimic to SNRCLA is hyalinizing salivary clear cell carcinoma; only focal CA-IX expression was demonstrated in 1 of 2 cases studied. Carbonic anhydrase expression in Schneiderian tissue speaks to its role in regulating the ion concentration of sinonasal secretions and may also explain the origin of this rare tumor. |
| doi_str_mv | 10.1016/j.humpath.2015.06.017 |
| format | Article |
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One case submitted in consultation demonstrated robust carbonic anhydrase IX (CA-IX) expression, leading us to a broader inquiry of CA-IX and carbonic anhydrase II (CA-II) expression in other SNRCLA, Schneiderian tissues, and histologic mimickers. Robust cytoplasmic and membranous CA-IX expression is demonstrated in 6 of 7 SNRCLAs; CA-II expression was demonstrated in 2 of 5 cases. Robust, diffuse CA-II expression is demonstrated throughout sinonasal seromucinous glands in all 10 normal Schneiderian samples. CA-IX is also expressed in all normal sinonasal samples, albeit focally. The closest salivary mimic to SNRCLA is hyalinizing salivary clear cell carcinoma; only focal CA-IX expression was demonstrated in 1 of 2 cases studied. Carbonic anhydrase expression in Schneiderian tissue speaks to its role in regulating the ion concentration of sinonasal secretions and may also explain the origin of this rare tumor.</description><identifier>ISSN: 0046-8177</identifier><identifier>EISSN: 1532-8392</identifier><identifier>DOI: 10.1016/j.humpath.2015.06.017</identifier><identifier>PMID: 26299508</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Adenocarcinoma ; Aged ; Aged, 80 and over ; Antigens ; Carbonic anhydrase ; Carbonic Anhydrases - metabolism ; Carcinoma, Renal Cell - metabolism ; Carcinoma, Renal Cell - pathology ; Carcinoma, Renal Cell - surgery ; Cytoplasm ; Female ; Humans ; Hypoxia ; Male ; Metastasis ; Middle Aged ; Nose Neoplasms - metabolism ; Nose Neoplasms - pathology ; Nose Neoplasms - surgery ; Pathology ; Renal cell ; Renal cell–like ; Sinonasal ; Tumors</subject><ispartof>Human pathology, 2015-11, Vol.46 (11), p.1598-1606</ispartof><rights>Elsevier Inc.</rights><rights>2015 Elsevier Inc.</rights><rights>Copyright © 2015 Elsevier Inc. All rights reserved.</rights><rights>Copyright Elsevier Limited Nov 2015</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c518t-ed9c1d835aa3518a2108607560d7dcf94735eac25a67dd1c0fa706732da8e3ba3</citedby><cites>FETCH-LOGICAL-c518t-ed9c1d835aa3518a2108607560d7dcf94735eac25a67dd1c0fa706732da8e3ba3</cites><orcidid>0000-0002-9312-2036</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.humpath.2015.06.017$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>315,781,785,3551,27929,27930,46000</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26299508$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Shen, Tiansheng, MD, PhD</creatorcontrib><creatorcontrib>Shi, Qiuying, MD</creatorcontrib><creatorcontrib>Velosa, Claudia, MD</creatorcontrib><creatorcontrib>Bai, Shuting, MD, PhD</creatorcontrib><creatorcontrib>Thompson, Lester, MD</creatorcontrib><creatorcontrib>Simpson, Roderick, MD</creatorcontrib><creatorcontrib>Wei, Shi, MD, PhD</creatorcontrib><creatorcontrib>Brandwein-Gensler, Margaret, MD</creatorcontrib><title>Sinonasal renal cell–like adenocarcinomas: robust carbonic anhydrase expression</title><title>Human pathology</title><addtitle>Hum Pathol</addtitle><description>Summary We report 3 new patients with sinonasal renal cell–like adenocarcinoma (SNRCLA). One case submitted in consultation demonstrated robust carbonic anhydrase IX (CA-IX) expression, leading us to a broader inquiry of CA-IX and carbonic anhydrase II (CA-II) expression in other SNRCLA, Schneiderian tissues, and histologic mimickers. Robust cytoplasmic and membranous CA-IX expression is demonstrated in 6 of 7 SNRCLAs; CA-II expression was demonstrated in 2 of 5 cases. Robust, diffuse CA-II expression is demonstrated throughout sinonasal seromucinous glands in all 10 normal Schneiderian samples. CA-IX is also expressed in all normal sinonasal samples, albeit focally. The closest salivary mimic to SNRCLA is hyalinizing salivary clear cell carcinoma; only focal CA-IX expression was demonstrated in 1 of 2 cases studied. Carbonic anhydrase expression in Schneiderian tissue speaks to its role in regulating the ion concentration of sinonasal secretions and may also explain the origin of this rare tumor.</description><subject>Adenocarcinoma</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Antigens</subject><subject>Carbonic anhydrase</subject><subject>Carbonic Anhydrases - metabolism</subject><subject>Carcinoma, Renal Cell - metabolism</subject><subject>Carcinoma, Renal Cell - pathology</subject><subject>Carcinoma, Renal Cell - surgery</subject><subject>Cytoplasm</subject><subject>Female</subject><subject>Humans</subject><subject>Hypoxia</subject><subject>Male</subject><subject>Metastasis</subject><subject>Middle Aged</subject><subject>Nose Neoplasms - metabolism</subject><subject>Nose Neoplasms - pathology</subject><subject>Nose Neoplasms - surgery</subject><subject>Pathology</subject><subject>Renal cell</subject><subject>Renal cell–like</subject><subject>Sinonasal</subject><subject>Tumors</subject><issn>0046-8177</issn><issn>1532-8392</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkc-KFDEQhxtR3NnVR1AavHjptpJ0km4PiizrH1gQWT2HmqSGyWx3Z0y6xbn5Dr6hT2KaGRX24iWB4qtfUl8VxRMGNQOmXuzq7TzscdrWHJisQdXA9L1ixaTgVSs6fr9YATSqapnWZ8V5SjsAxmQjHxZnXPGuk9Cuik83fgwjJuzLSGM-LfX9rx8_e39LJToag8VoMzNgelnGsJ7TVObSOozeljhuDy5iopK-7yOl5MP4qHiwwT7R49N9UXx5e_X58n11_fHdh8s315WVrJ0qcp1lrhUSUeQCcgatAi0VOO3spmu0kISWS1TaOWZhgxqUFtxhS2KN4qJ4fszdx_B1pjSZwafl9zhSmJNhWiildduIjD67g-7CHPO0C8VbxbRqZKbkkbIxpBRpY_bRDxgPhoFZnJudOTk3i3MDymTnue_pKX1eD-T-dv2RnIHXR4Cyjm-eoknW02jJ-Uh2Mi74_z7x6k6C7X1eAPa3dKD0bxqTuAFzsyx-2TuTAFxoIX4D4tyrbA</recordid><startdate>20151101</startdate><enddate>20151101</enddate><creator>Shen, Tiansheng, MD, PhD</creator><creator>Shi, Qiuying, MD</creator><creator>Velosa, Claudia, MD</creator><creator>Bai, Shuting, MD, PhD</creator><creator>Thompson, Lester, MD</creator><creator>Simpson, Roderick, MD</creator><creator>Wei, Shi, MD, PhD</creator><creator>Brandwein-Gensler, Margaret, MD</creator><general>Elsevier Inc</general><general>Elsevier Limited</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>K9.</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-9312-2036</orcidid></search><sort><creationdate>20151101</creationdate><title>Sinonasal renal cell–like adenocarcinomas: robust carbonic anhydrase expression</title><author>Shen, Tiansheng, MD, PhD ; Shi, Qiuying, MD ; Velosa, Claudia, MD ; Bai, Shuting, MD, PhD ; Thompson, Lester, MD ; Simpson, Roderick, MD ; Wei, Shi, MD, PhD ; Brandwein-Gensler, Margaret, MD</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c518t-ed9c1d835aa3518a2108607560d7dcf94735eac25a67dd1c0fa706732da8e3ba3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Adenocarcinoma</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Antigens</topic><topic>Carbonic anhydrase</topic><topic>Carbonic Anhydrases - metabolism</topic><topic>Carcinoma, Renal Cell - metabolism</topic><topic>Carcinoma, Renal Cell - pathology</topic><topic>Carcinoma, Renal Cell - surgery</topic><topic>Cytoplasm</topic><topic>Female</topic><topic>Humans</topic><topic>Hypoxia</topic><topic>Male</topic><topic>Metastasis</topic><topic>Middle Aged</topic><topic>Nose Neoplasms - metabolism</topic><topic>Nose Neoplasms - pathology</topic><topic>Nose Neoplasms - surgery</topic><topic>Pathology</topic><topic>Renal cell</topic><topic>Renal cell–like</topic><topic>Sinonasal</topic><topic>Tumors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Shen, Tiansheng, MD, PhD</creatorcontrib><creatorcontrib>Shi, Qiuying, MD</creatorcontrib><creatorcontrib>Velosa, Claudia, MD</creatorcontrib><creatorcontrib>Bai, Shuting, MD, PhD</creatorcontrib><creatorcontrib>Thompson, Lester, MD</creatorcontrib><creatorcontrib>Simpson, Roderick, MD</creatorcontrib><creatorcontrib>Wei, Shi, MD, PhD</creatorcontrib><creatorcontrib>Brandwein-Gensler, Margaret, MD</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><jtitle>Human pathology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Shen, Tiansheng, MD, PhD</au><au>Shi, Qiuying, MD</au><au>Velosa, Claudia, MD</au><au>Bai, Shuting, MD, PhD</au><au>Thompson, Lester, MD</au><au>Simpson, Roderick, MD</au><au>Wei, Shi, MD, PhD</au><au>Brandwein-Gensler, Margaret, MD</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Sinonasal renal cell–like adenocarcinomas: robust carbonic anhydrase expression</atitle><jtitle>Human pathology</jtitle><addtitle>Hum Pathol</addtitle><date>2015-11-01</date><risdate>2015</risdate><volume>46</volume><issue>11</issue><spage>1598</spage><epage>1606</epage><pages>1598-1606</pages><issn>0046-8177</issn><eissn>1532-8392</eissn><abstract>Summary We report 3 new patients with sinonasal renal cell–like adenocarcinoma (SNRCLA). One case submitted in consultation demonstrated robust carbonic anhydrase IX (CA-IX) expression, leading us to a broader inquiry of CA-IX and carbonic anhydrase II (CA-II) expression in other SNRCLA, Schneiderian tissues, and histologic mimickers. Robust cytoplasmic and membranous CA-IX expression is demonstrated in 6 of 7 SNRCLAs; CA-II expression was demonstrated in 2 of 5 cases. Robust, diffuse CA-II expression is demonstrated throughout sinonasal seromucinous glands in all 10 normal Schneiderian samples. CA-IX is also expressed in all normal sinonasal samples, albeit focally. The closest salivary mimic to SNRCLA is hyalinizing salivary clear cell carcinoma; only focal CA-IX expression was demonstrated in 1 of 2 cases studied. Carbonic anhydrase expression in Schneiderian tissue speaks to its role in regulating the ion concentration of sinonasal secretions and may also explain the origin of this rare tumor.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>26299508</pmid><doi>10.1016/j.humpath.2015.06.017</doi><tpages>9</tpages><orcidid>https://orcid.org/0000-0002-9312-2036</orcidid></addata></record> |
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| subjects | Adenocarcinoma Aged Aged, 80 and over Antigens Carbonic anhydrase Carbonic Anhydrases - metabolism Carcinoma, Renal Cell - metabolism Carcinoma, Renal Cell - pathology Carcinoma, Renal Cell - surgery Cytoplasm Female Humans Hypoxia Male Metastasis Middle Aged Nose Neoplasms - metabolism Nose Neoplasms - pathology Nose Neoplasms - surgery Pathology Renal cell Renal cell–like Sinonasal Tumors |
| title | Sinonasal renal cell–like adenocarcinomas: robust carbonic anhydrase expression |
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