Challenges and Opportunities in the Discovery of New Therapeutics Targeting the Kynurenine Pathway

The kynurenine pathway is responsible for the metabolism of more than 95% of dietary tryptophan (TRP) and produces numerous bioactive metabolites. Recent studies have focused on three enzymes in this pathway: indoleamine dioxygenase (IDO1), kynurenine monooxygenase (KMO), and kynurenine aminotransfe...

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Veröffentlicht in:	Journal of medicinal chemistry 2015-11, Vol.58 (22), p.8762-8782
Hauptverfasser:	Dounay, Amy B, Tuttle, Jamison B, Verhoest, Patrick R
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antineoplastic Agents - chemical synthesis Antineoplastic Agents - pharmacology Central Nervous System Diseases - drug therapy Enzyme Inhibitors - pharmacology Enzyme Inhibitors - therapeutic use Humans Indoleamine-Pyrrole 2,3,-Dioxygenase - antagonists & inhibitors Kynurenine - metabolism Kynurenine 3-Monooxygenase - antagonists & inhibitors Signal Transduction - drug effects Transaminases - antagonists & inhibitors
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